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1.发明申请公开(公告)号：US20120003644A1
公开(公告)日：2012-01-05
申请号：US13153569
申请日：2011-06-06
申请人： Karl Skorecki , Shay Tzur , Saharon Rosset , Walter Gabriel Wasser , Doron M. Behar , Revital Shemer
发明人： Karl Skorecki , Shay Tzur , Saharon Rosset , Walter Gabriel Wasser , Doron M. Behar , Revital Shemer
IPC分类号： C12Q1/68 , G01N33/566 , C07H21/00 , C07K16/18
CPC分类号： C12Q1/6883 , C12Q1/703 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172 , G01N33/6893 , G01N2333/775 , G01N2800/50
摘要： Provided are methods and kits for determining predisposition of a subject to develop a kidney disease, by identifying in a sample of the subject at least one APOL1 polypeptide variant which is characterized by a higher trypanolytic activity on Trypanosoma brucei rhodesiense as compared to the trypanolytic activity of wild type APOL1 polypeptide as set forth in SEQ ID NO:1 on the Trypanosoma brucei rhodesiense under identical assay conditions; or at least one APOL1 nucleotide mutation in the APLO1 genomic sequence set forth in SEQ ID NO:3, wherein the at least one nucleotide mutation or polypeptide variant being in linkage disequlibrium (LD) with the S342G mutation in the APOL1 polypeptide set forth in SEQ ID NO:1, wherein presence of the APOL1 polypeptide variant indicates increased predisposition of the subject to develop the kidney disease.
摘要翻译： 提供了用于确定受试者的易感性以发展肾脏疾病的方法和试剂盒，通过在受试者样品中鉴定至少一种APOL1多肽变体，其特征在于与锥虫属罗非鱼相比具有更高的锥虫解活性， 野生型APOL1多肽，如同样的测定条件下的罗丹明锥虫在SEQ ID NO：1中所示; 或在SEQ ID NO：3中列出的APLO1基因组序列中的至少一个APOL1核苷酸突变，其中所述至少一个核苷酸突变或多肽变体与APOL1多肽中所示的S342G突变处于连锁不平衡（LD） ID NO：1，其中APOL1多肽变体的存在表明受试者发生肾脏疾病的易感性增加。
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公开(公告)号：US20080221954A1
公开(公告)日：2008-09-11
申请号：US12050371
申请日：2008-03-18
申请人： Claudia REISZ , Saharon Rosset , Bianca Zadrozny
发明人： Claudia REISZ , Saharon Rosset , Bianca Zadrozny
CPC分类号： G06Q30/02 , G06Q10/063 , G06Q10/063112 , G06Q10/0639 , G06Q30/0202 , G06Q30/0204
摘要： A method and system perform ranking-based evaluations for regression models that are often appropriate for marketing tasks and are more robust to outliers than traditional residual-based performance measures. The output provided by the method and system provides visualization that can offer insights about local model performance and outliers. Several models can be compared to each other to identify the “best” model and, therefore, the “best” model data for the particular marketing task.
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3.发明授权公开(公告)号：US08255346B2
公开(公告)日：2012-08-28
申请号：US12616534
申请日：2009-11-11
申请人： Naoki Abe , Yan Liu , Aurelie C. Lozano , Saharon Rosset , Grzegorz Swirszcz
发明人： Naoki Abe , Yan Liu , Aurelie C. Lozano , Saharon Rosset , Grzegorz Swirszcz
摘要： A “variable group selection” system and method in which constructs are based upon a training data set, a regression modeling module that takes into account information on groups of related predictor variables given as input and outputs a regression model with selected variable groups. Optionally, the method can be employed as a component in methods of temporal causal modeling, which are applied on a time series training data set, and output a model of causal relationships between the multiple times series in the data.
摘要翻译： 一种“可变组选择”系统和方法，其中构造基于训练数据集，回归建模模块考虑了作为输入给出的相关预测变量组的信息，并输出具有选定变量组的回归模型。 可选地，该方法可以用作时间因果建模方法中的组件，其应用于时间序列训练数据集，并且输出数据中多次序列之间的因果关系模型。
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公开(公告)号：US08140476B2
公开(公告)日：2012-03-20
申请号：US12639005
申请日：2009-12-16
申请人： Ehud Aharoni , Hani Neuvirth , Saharon Rosset
发明人： Ehud Aharoni , Hani Neuvirth , Saharon Rosset
CPC分类号： G06F17/30303 , G06F17/30368
摘要： A method and computer system for monitoring and controlling the quality of tests performed upon a database. A statistical quality layer is provided, which for each new test to be executed on the database, provides recommendations as to a confidence level to be applied to the test and to a number of additional data records to be added to the database in order to maintain the total expected number of type-I errors of tests performed upon the database. The method and computer system further provide access control of users to the database.
摘要翻译： 一种监测和控制数据库执行测试质量的方法和计算机系统。 提供统计质量层，对于在数据库上执行的每个新测试，提供关于要应用于测试的置信水平以及要添加到数据库中的若干附加数据记录以建立维护 在数据库上执行的测试类型I错误的总预期数量。 该方法和计算机系统进一步提供用户对数据库的访问控制。
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公开(公告)号：US07725340B2
公开(公告)日：2010-05-25
申请号：US12050371
申请日：2008-03-18
申请人： Claudia Reisz , Saharon Rosset , Bianca Zadrozny
发明人： Claudia Reisz , Saharon Rosset , Bianca Zadrozny
IPC分类号： G06F17/18
CPC分类号： G06Q30/02 , G06Q10/063 , G06Q10/063112 , G06Q10/0639 , G06Q30/0202 , G06Q30/0204
摘要： A method and system perform ranking-based evaluations for regression models that are often appropriate for marketing tasks and are more robust to outliers than traditional residual-based performance measures. The output provided by the method and system provides visualization that can offer insights about local model performance and outliers. Several models can be compared to each other to identify the “best” model and, therefore, the “best” model data for the particular marketing task.
摘要翻译： 一种方法和系统对于经常适用于营销任务的回归模型执行基于排序的评估，并且比传统的基于剩余的绩效指标更为鲁棒。 方法和系统提供的输出提供可视化，可以提供有关本地模型性能和异常值的见解。 可以将几个模型相互比较，以确定“最佳”模型，从而确定特定营销任务的“最佳”模型数据。
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6.发明申请公开(公告)号：US20080015910A1
公开(公告)日：2008-01-17
申请号：US11456663
申请日：2006-07-11
申请人： Claudia Reisz , Saharon Rosset , Bianca Zadrozny
发明人： Claudia Reisz , Saharon Rosset , Bianca Zadrozny
IPC分类号： G06F17/50
CPC分类号： G06Q30/02 , G06Q10/063 , G06Q10/063112 , G06Q10/0639 , G06Q30/0202 , G06Q30/0204
摘要： A method and system perform ranking-based evaluations for regression models that are often appropriate for marketing tasks and are more robust to outliers than traditional residual-based performance measures. The output provided by the method and system provides visualization that can offer insights about local model performance and outliers. Several models can be compared to each other to identify the “best” model and, therefore, the “best” model data for the particular marketing task.
摘要翻译： 一种方法和系统对于经常适用于营销任务的回归模型执行基于排序的评估，并且比传统的基于剩余的绩效指标更为鲁棒。 方法和系统提供的输出提供可视化，可以提供有关本地模型性能和异常值的见解。 可以将几个模型相互比较，以确定“最佳”模型，从而确定特定营销任务的“最佳”模型数据。
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公开(公告)号：US10927414B2
公开(公告)日：2021-02-23
申请号：US16449585
申请日：2019-06-24
申请人： Technion Research & Development Foundation Limited , Ramot at Tel-Aviv University Ltd. , Walter Gabriel Wasser , Rambam Med-Tech Ltd.
发明人： Karl Skorecki , Shay Tzur , Saharon Rosset , Walter Gabriel Wasser , Doron M. Behar , Revital Shemer
IPC分类号： C12Q1/6883 , C12Q1/70 , G01N33/68
摘要： Provided are methods and kits for determining predisposition of a subject to develop a kidney disease, by identifying in a sample of the subject at least one APOL1 polypeptide variant which is characterized by a higher trypanolytic activity on Trypanosoma brucei rhodesiense as compared to the trypanolytic activity of wild type APOL1 polypeptide as set forth in SEQ ID NO:1 on the Trypanosoma brucei rhodesiense under identical assay conditions; or at least one APOL1 nucleotide mutation in the APLO1 genomic sequence set forth in SEQ ID NO:3, wherein the at least one nucleotide mutation or polypeptide variant being in linkage disequilibrium (LD) with the S342G mutation in the APOL1 polypeptide set forth in SEQ ID NO:1, wherein presence of the APOL1 polypeptide variant indicates increased predisposition of the subject to develop the kidney disease.
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公开(公告)号：US20110145291A1
公开(公告)日：2011-06-16
申请号：US12639005
申请日：2009-12-16
IPC分类号： G06F17/30
CPC分类号： G06F17/30303 , G06F17/30368
摘要： A method and computer system for monitoring and controlling the quality of tests performed upon a database. A statistical quality layer is provided, which for each new test to be executed on the database, provides recommendations as to a confidence level to be applied to the test and to a number of additional data records to be added to the database in order to maintain the total expected number of type-I errors of tests performed upon the database. The method and computer system further provide access control of users to the database.
摘要翻译： 一种监测和控制数据库执行测试质量的方法和计算机系统。 提供统计质量层，对于在数据库上执行的每个新测试，提供关于要应用于测试的置信水平以及要添加到数据库中的若干附加数据记录以建立维护 在数据库上执行的测试类型I错误的总预期数量。 该方法和计算机系统进一步提供用户对数据库的访问控制。
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9.发明申请公开(公告)号：US20110112998A1
公开(公告)日：2011-05-12
申请号：US12616534
申请日：2009-11-11
申请人： Naoki Abe , Yan Liu , Aurelie C. Lozano , Saharon Rosset , Grzegorz Swirszcz
发明人： Naoki Abe , Yan Liu , Aurelie C. Lozano , Saharon Rosset , Grzegorz Swirszcz
摘要： A “variable group selection” system and method in which constructs are based upon a training data set, a regression modeling module that takes into account information on groups of related predictor variables given as input and outputs a regression model with selected variable groups. Optionally, the method can be employed as a component in methods of temporal causal modeling, which are applied on a time series training data set, and output a model of causal relationships between the multiple times series in the data.
摘要翻译： 一种“可变组选择”系统和方法，其中构造基于训练数据集，回归建模模块考虑了作为输入给出的相关预测变量组的信息，并输出具有选定变量组的回归模型。 可选地，该方法可以用作时间因果建模方法中的组件，其应用于时间序列训练数据集，并且输出数据中多次序列之间的因果关系模型。
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公开(公告)号：US20080208788A1
公开(公告)日：2008-08-28
申请号：US11679430
申请日：2007-02-27
申请人： Srujana Merugu , Claudia Perlich , Saharon Rosset
发明人： Srujana Merugu , Claudia Perlich , Saharon Rosset
CPC分类号： G06Q30/0202 , G06Q30/02
摘要： A method (and system) of predicting an unobserved target variable includes building a graphical predictive model from domain knowledge, which takes advantage of conditional independence to facilitate inference about the unobserved target variable, given observations of other variables in the graphical predictive model from a plurality of information sources.
摘要翻译： 预测未观察目标变量的方法（和系统）包括从领域知识构建图形预测模型，其利用条件独立性来促进关于未观察到的目标变量的推论，给定来自多个图形预测模型中的其他变量的观测值 的信息来源。
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