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公开(公告)号：US07896873B2
公开(公告)日：2011-03-01
申请号：US10596091
申请日：2004-12-01
CPC分类号： A61N1/056 , A61B18/1492 , A61B2017/00911 , A61B2018/00577 , A61B2090/374 , A61N1/0563 , A61N1/086 , H01B1/04
摘要： The present invention relates to an electrode catheter for defibrillation, mapping or ablation of cardiac tissue. Said catheter comprises a terminal (40) on the proximal end of the electrode catheter and one or more sensing and/or treatment electrodes (14, 16) that are situated on or in the vicinity of the distal end of the electrode catheter, in addition to at least one electric conductor (44, 62), which is used to electrically connect a respective sensing or treatment electrode to the terminal. The electric conductor (44, 62) is composed of carbon and the electrode catheter is configured to be suitable for us as part of magnetic resonance tomography and for connection to electrophysiotherapy equipment. Said catheter comprises at least one defibrillation electrode, or at least one sensing electrode (14, 16) for the recording and evaluation of cardiac tissue potentials, or at least one treatment electrode (14) for delivering high-frequency currents for ablation purposes.
摘要翻译： 本发明涉及用于除颤，映射或消融心脏组织的电极导管。 所述导管包括在电极导管的近端上的端子（40）和位于电极导管的远端附近或附近的一个或多个感测和/或治疗电极（14,16），另外 至少一个电导体（44,62），其用于将相应的感测或处理电极电连接到端子。 电导体（44,62）由碳组成，并且电极导管被配置为适合作为磁共振层析成像的一部分并用于与电疗设备的连接。 所述导管包括用于记录和评估心脏组织电位的至少一个除颤电极或至少一个感测电极（14,16），或至少一个用于输送用于消融目的的高频电流的治疗电极（14）。
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公开(公告)号：US20070100232A1
公开(公告)日：2007-05-03
申请号：US10596091
申请日：2004-12-01
CPC分类号： A61N1/056 , A61B18/1492 , A61B2017/00911 , A61B2018/00577 , A61B2090/374 , A61N1/0563 , A61N1/086 , H01B1/04
摘要： The present invention relates to an electrode catheter for defibrillation, mapping or ablation of cardiac tissue. Said catheter comprises a terminal (40) on the proximal end of the electrode catheter and one or more sensing and/or treatment electrodes (14, 16) that are situated on or in the vicinity of the distal end of the electrode catheter, in addition to at least one electric conductor (44, 62), which is used to electrically connect a respective sensing or treatment electrode to the terminal. The electric conductor (44, 62) is composed of carbon and the electrode catheter is configured to be suitable for us as part of magnetic resonance tomography and for connection to electrophysiotherapy equipment. Said catheter comprises at least one defibrillation electrode, or at least one sensing electrode (14, 16) for the recording and evaluation of cardiac tissue potentials, or at least one treatment electrode (14) for delivering high-frequency currents for ablation purposes.
摘要翻译： 本发明涉及用于除颤，映射或消融心脏组织的电极导管。 所述导管包括在电极导管的近端上的端子（40）和位于电极导管的远端附近或附近的一个或多个感测和/或治疗电极（14,16），另外 至少一个电导体（44,62），其用于将相应的感测或处理电极电连接到端子。 电导体（44,62）由碳组成，并且电极导管被配置为适合作为磁共振层析成像的一部分并用于与电疗设备的连接。 所述导管包括用于记录和评估心脏组织电位的至少一个除颤电极或至少一个感测电极（14,16），或用于递送用于消融目的的高频电流的至少一个治疗电极（14）。
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3.发明授权公开(公告)号：US09624307B2
公开(公告)日：2017-04-18
申请号：US14003963
申请日：2012-03-09
IPC分类号： A61K38/48 , C07K14/81 , C07K16/40 , A61K38/55 , A61K38/57 , A61K49/00 , A61K49/14 , G01N33/50 , A61K39/395 , C07K16/36
CPC分类号： C07K16/40 , A61K38/4846 , A61K38/556 , A61K38/57 , A61K39/3955 , A61K49/0004 , A61K49/0008 , A61K49/14 , C07K14/811 , C07K14/8114 , C07K16/36 , G01N33/5088 , G01N2500/10
摘要： Silent brain ischemia (SBI) or ischemia of other organs can result from an embolism that is introduced into the arterial system during a medical procedure. The application provides a method of administering a FXII inhibitor in a patient receiving a medical procedure and animal models useful for studying ischemia including SBI and ischemia in other organs, and for evaluating candidate therapeutics.
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4.发明申请FACTOR XII INHIBITORS FOR THE TREATMENT OF SILENT BRAIN ISCHEMIA AND ISCHEMIA OF OTHER ORGANS 有权因子XII抑制剂治疗其他器官的静止脑组织和间质公开(公告)号：US20140072572A1
公开(公告)日：2014-03-13
申请号：US14003963
申请日：2012-03-09
CPC分类号： C07K16/40 , A61K38/4846 , A61K38/556 , A61K38/57 , A61K39/3955 , A61K49/0004 , A61K49/0008 , A61K49/14 , C07K14/811 , C07K14/8114 , C07K16/36 , G01N33/5088 , G01N2500/10
摘要： Silent brain ischemia (SBI) or ischemia of other organs can result from an embolism that is introduced into the arterial system during a medical procedure. The application provides a method of administering a FXII inhibitor in a patient receiving a medical procedure and animal models useful for studying ischemia including SBI and ischemia in other organs, and for evaluating candidate therapeutics.
摘要翻译： 静息脑缺血（SBI）或其他器官缺血可能是由于在医疗过程中引入动脉系统的栓塞引起的。 该应用提供了在接受医学过程的患者和可用于研究缺血（包括其他器官中的SBI和缺血）和用于评估候选治疗剂的缺血的动物模型中施用FXII抑制剂的方法。
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5.发明申请COMPOSITIONS AND METHODS FOR THE TREATMENT OF ATHEROSCLEROSIS AND OTHER RELATED DISEASES 审中-公开用于治疗甲状腺功能亢进症和其他相关疾病的组合物和方法公开(公告)号：US20110077216A1
公开(公告)日：2011-03-31
申请号：US12895278
申请日：2010-09-30
申请人： Christian Kastrup , Daniel Griffith Anderson , Robert S. Langer , Haeshin Lee , Matthias Nahrendorf , Ralph Weissleder , Jose Luiz Figueiredo
发明人： Christian Kastrup , Daniel Griffith Anderson , Robert S. Langer , Haeshin Lee , Matthias Nahrendorf , Ralph Weissleder , Jose Luiz Figueiredo
IPC分类号： A61K31/728 , A61P9/10 , C08B37/04 , A61K31/734 , C07C237/20 , A61K31/165
CPC分类号： A61K47/6903 , A61K47/60 , A61K47/61
摘要： The present invention provides compositions and methods for the treatment of atherosclerosis and other related diseases. In some embodiments, a method comprises providing a composition and forming a coating of the composition on at least a portion of the interior and/or exterior surface of a tissue lumen or other body surface. The composition may remain associated with the tissue lumen or other body surface even in the presence of a strong flow of a fluid (e.g., blood flow in a blood vessel). The composition may associate with the tissue lumen via a plurality of covalent bonds. In some cases, the compositions may comprise at least one additive, for example, a therapeutically active agent or an imaging agent.
摘要翻译： 本发明提供了治疗动脉粥样硬化和其它相关疾病的组合物和方法。 在一些实施方案中，方法包括提供组合物并在组织内腔或其他身体表面的内部和/或外表面的至少一部分上形成组合物的涂层。 即使在存在强流动的流体（例如血管中的血液流动）的情况下，组合物也可能与组织腔或其他身体表面相关联。 组合物可以经由多个共价键与组织内腔结合。 在一些情况下，组合物可以包含至少一种添加剂，例如治疗活性剂或成像剂。
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