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1.Method for reversing the immunosuppressive effects of the melanoma inhibitory activity "mia" 审中-公开
标题翻译: 逆转黑色素瘤抑制活性的免疫抑制作用的方法“mia”公开(公告)号:US20060252716A1
公开(公告)日:2006-11-09
申请号:US10220265
申请日:2001-03-10
申请人: Karl-Hermann Schlingensiepen , Reimar Schlingensiepen , Rainer Apfel , Wolfgang Brysch , Piotr Jachimczak , Ulrich Bogdahn
发明人: Karl-Hermann Schlingensiepen , Reimar Schlingensiepen , Rainer Apfel , Wolfgang Brysch , Piotr Jachimczak , Ulrich Bogdahn
IPC分类号: A61K48/00
CPC分类号: A61K38/1709 , A61K31/70 , A61K31/7088 , A61K39/395
摘要: A method for stimulating immune cells and/or the immune system, and/or reducing invasion and/or metastasis of tumor cells by inhibiting expression and/or functional activity of “Melanoma Inhibitory Activity” MIA.
摘要翻译: 通过抑制“黑素瘤抑制活性”MIA的表达和/或功能活性来刺激免疫细胞和/或免疫系统和/或减少肿瘤细胞的侵袭和/或转移的方法。
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公开(公告)号:US08148493B2
公开(公告)日:2012-04-03
申请号:US12289153
申请日:2008-10-21
申请人: Anja-Katrin Bosserhoff , Reinhard Buettner , Mara Szyrach , Guenter Auerbach , Piotr Jachimczak , Karl-Hermann Schlingensiepen
发明人: Anja-Katrin Bosserhoff , Reinhard Buettner , Mara Szyrach , Guenter Auerbach , Piotr Jachimczak , Karl-Hermann Schlingensiepen
IPC分类号: A61K38/04
CPC分类号: C07K16/2842 , A61K38/00 , C07K7/06 , C07K7/08 , C07K16/3053
摘要: The present invention is directed to peptides, antibodies and antibody fragments inhibiting activity of “Melanoma Inhibitory Activity” (MIA).
摘要翻译: 本发明涉及抑制“黑素瘤抑制活性”(MIA)活性的肽,抗体和抗体片段。
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公开(公告)号:US20120208774A1
公开(公告)日:2012-08-16
申请号:US13405407
申请日:2012-02-27
申请人: Anja-Katrin Bosserhoff , Reinhard Buettner , Mara Szyrach , Guenter Auerbach , Piotr Jachimczak , Karl-Hermann Schlingensiepen
发明人: Anja-Katrin Bosserhoff , Reinhard Buettner , Mara Szyrach , Guenter Auerbach , Piotr Jachimczak , Karl-Hermann Schlingensiepen
CPC分类号: C07K16/2842 , A61K38/00 , C07K7/06 , C07K7/08 , C07K16/3053
摘要: The present invention is directed to peptides, antibodies and antibody fragments inhibiting activity of “Melanoma Inhibitory Activity” (MIA).
摘要翻译: 本发明涉及抑制“黑素瘤抑制活性”(MIA)活性的肽,抗体和抗体片段。
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公开(公告)号:US20100273705A1
公开(公告)日:2010-10-28
申请号:US12289153
申请日:2008-10-21
申请人: Anja-Katrin Bosserhoff , Reinhard Buettner , Mara Szyrach , Guenter Auerbach , Piotr Jachimczak , Karl-Hermann Schlingensiepen
发明人: Anja-Katrin Bosserhoff , Reinhard Buettner , Mara Szyrach , Guenter Auerbach , Piotr Jachimczak , Karl-Hermann Schlingensiepen
CPC分类号: C07K16/2842 , A61K38/00 , C07K7/06 , C07K7/08 , C07K16/3053
摘要: The present invention is directed to peptides, antibodies and antibody fragments inhibiting activity of “Melanoma Inhibitory Activity” (MIA).
摘要翻译: 本发明涉及抑制“黑素瘤抑制活性”(MIA)活性的肽,抗体和抗体片段。
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公开(公告)号:US20070155685A1
公开(公告)日:2007-07-05
申请号:US10591048
申请日:2005-02-28
申请人: Karl-Hermann Schlingensiepen , Relmar Schlingensiepen , Piotr Jachimczak , Gerhard Stauder , Astrid Bischof , Michael Hafner , Tamara Egger
发明人: Karl-Hermann Schlingensiepen , Relmar Schlingensiepen , Piotr Jachimczak , Gerhard Stauder , Astrid Bischof , Michael Hafner , Tamara Egger
CPC分类号: A61K31/713 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N2310/11
摘要: The present invention is related to pharmaceutical compositions for the inhibition of metastases and treatment of cancer such as bladder carcinoma, colon cancer, endometrial cancer, hepatocellular carcinoma, leukemia, lymphoma, melanoma, non-small cell lung cancer (NSCLC), ovarian cancer, pancreatic cancer, prostate cancer, soft tissue cancer, renal cancer, osteosarcoma, mesothelioma, myeloma multiple, bladder carcinoma and esophagcal cancer as well as the use of these pharmaceutical compositions for the treatment of said metastases and cancers. Another aspect of this invention are new antisense oligonucleotides inhibiting the formation of human interleukin 10 and their synthesis. A further aspect of this invention is the use IL-10 antisense oligonucleotides for the preparation of pharmaceutical compositions and for the treatment of cancer and metastases.
摘要翻译: 本发明涉及用于抑制转移和治疗癌症的药物组合物,例如膀胱癌,结肠癌,子宫内膜癌,肝细胞癌,白血病,淋巴瘤,黑素瘤,非小细胞肺癌(NSCLC),卵巢癌, 胰腺癌,前列腺癌,软组织癌,肾癌,骨肉瘤,间皮瘤,骨髓瘤多发,膀胱癌和食道癌,以及这些药物组合物用于治疗所述转移和癌症的用途。 本发明的另一方面是抑制人白介素10的形成及其合成的新的反义寡核苷酸。 本发明的另一方面是使用IL-10反义寡核苷酸用于制备药物组合物和用于治疗癌症和转移瘤。
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公开(公告)号:US20060128607A1
公开(公告)日:2006-06-15
申请号:US10502771
申请日:2002-01-29
申请人: Anja-Katrin Bosserhoff , Reinhard Buettner , Mara Szyrach , Guenther Auerbach , Piotr Jachimczak , Karl-Hermann Schlingensiepen
发明人: Anja-Katrin Bosserhoff , Reinhard Buettner , Mara Szyrach , Guenther Auerbach , Piotr Jachimczak , Karl-Hermann Schlingensiepen
CPC分类号: C07K16/2842 , A61K38/00 , C07K7/06 , C07K7/08 , C07K16/3053
摘要: The present invention is directed to peptides, antibodies and antibody fragments inhibiting activity of “Melanoma Inhibitory Activity” (MIA).
摘要翻译: 本发明涉及抑制“黑素瘤抑制活性”(MIA)活性的肽,抗体和抗体片段。
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