利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

7 条记录 (耗时 0.025 秒)

    Antibodies for use in identifying and/or scoring prostate cancer and androgen receptor-dependent gene expression control
    5.
    发明授权
    Antibodies for use in identifying and/or scoring prostate cancer and androgen receptor-dependent gene expression control 有权
    用于鉴定和评估前列腺癌和雄激素受体依赖性基因表达控制的抗体

    公开(公告)号：US07858395B2

    公开(公告)日：2010-12-28

    申请号：US11995387

    申请日：2006-07-13

    申请人： Roland Schuele ,  Erich Metzger ,  Reinhard Buettner

    发明人： Roland Schuele ,  Erich Metzger ,  Reinhard Buettner

    IPC分类号： G01N33/53

    CPC分类号： G01N33/57434 ,  C07K16/3069 ,  C07K16/40 ,  G01N33/573 ,  G01N33/743 ,  G01N2500/00

    摘要： The invention relates to antibodies for use for modulating the activity of the lysine-specific demethylase (LSD1) in a mammal and to pharmaceutical and diagnostical compositions comprising such antibodies. The invention also relates to a method for identifying and/or scoring prostate carcinomas. Furthermore, the invention relates to the use of at least one siRNA (“short interfering RNA”) and/or at least one anti-LSD1 antibody for modulating the activity of the lysine-specific demethylase (LSD1) in a mammal or for the manufacture of a medicament for modulating the activity of the lysine-specific demethylase (LSD1) in a mammal. The invention also relates to a pharmaceutical composition for controlling the androgen receptor-dependent gene expression, comprising an effective dose of at least one siRNA and/or at least one anti-LSD1 antibody suitable for modulating the activity of the lysine-specific demethylase (LSD1) in a mammal. The invention also relates to a method for controlling the androgen receptor-dependent gene expression in a mammal, said process comprising the step of administering to said mammal, on a suitable route, an effective dose of a pharmaceutical composition modulating an activity of the lysine-specific demethylase (LSD1) in a mammal.

    摘要翻译： 本发明涉及用于调节哺乳动物中赖氨酸特异性脱甲基酶（LSD1）的活性的抗体以及包含此类抗体的药物和诊断组合物。 本发明还涉及用于鉴定和/或评分前列腺癌的方法。 此外，本发明涉及至少一种siRNA（“短干扰RNA”）和/或至少一种抗LSD1抗体用于调节哺乳动物或制造中的赖氨酸特异性脱甲基酶（LSD1）的活性的用途 的用于调节哺乳动物中赖氨酸特异性脱甲基酶（LSD1）的活性的药物。 本发明还涉及用于控制雄激素受体依赖性基因表达的药物组合物，其包含有效剂量的至少一种siRNA和/或至少一种抗LSD1抗体，其适于调节赖氨酸特异性脱甲基酶（LSD1 ）在哺乳动物中。 本发明还涉及一种用于控制哺乳动物中雄激素受体依赖性基因表达的方法，所述方法包括以下步骤：在合适的途径向所述哺乳动物施用有效剂量的调节赖氨酸 - 特异性脱甲基酶（LSD1）。

    HIGH RESOLUTION MELTING ANALYSIS AS A PRESCREENING TOOL
    6.
    发明申请
    HIGH RESOLUTION MELTING ANALYSIS AS A PRESCREENING TOOL 有权
    高分辨率熔融分析作为预处理工具

    公开(公告)号：US20140017682A1

    公开(公告)日：2014-01-16

    申请号：US13930638

    申请日：2013-06-28

    申请人： Reinhard Buettner ,  Stefanie Froehner ,  Sabine Merkelbach-Bruse ,  Jasmin Ney ,  Angelika Roesler

    发明人： Reinhard Buettner ,  Stefanie Froehner ,  Sabine Merkelbach-Bruse ,  Jasmin Ney ,  Angelika Roesler

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6886 ,  C12N9/14 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Y306/05002

    摘要： Compositions and methods for determining an increased likelihood of a response to a targeted treatment of a cancer disease including isolating genomic DNA from a patient sample, amplifying a fragment of DNA by means of PCR with a specific pair of amplification primers, determining if the amplified fragment comprises a wildtype sequence or a mutation by means of a High Resolution Melting Analysis (HRM), and correlating the presence or absence of a mutation with an increased likelihood of success of said targeted treatment. Respective primer pairs, compositions and kits are also claimed.

    摘要翻译： 用于确定对癌症疾病的靶向治疗的响应的可能性增加的组合物和方法，包括从患者样品分离基因组DNA，通过用特异性的一对扩增引物扩增DNA片段，确定扩增片段 包括通过高分辨率熔解分析（HRM）的野生型序列或突变，并且将突变的存在或不存在与所述靶向治疗的成功增加的可能性相关联。 还要求各种引物对，组合物和试剂盒。

    Antibodies For Use in Identifying and/or Scoring Prostate Cancer and Androgen Receptor-Dependent Gene Expression Control
    7.
    发明申请
    Antibodies For Use in Identifying and/or Scoring Prostate Cancer and Androgen Receptor-Dependent Gene Expression Control 有权
    用于鉴定和/或评估前列腺癌和雄激素受体依赖基因表达控制的抗体

    公开(公告)号：US20090104196A1

    公开(公告)日：2009-04-23

    申请号：US11995387

    申请日：2006-07-13

    申请人： Roland Schuele ,  Erich Metzger ,  Reinhard Buettner

    发明人： Roland Schuele ,  Erich Metzger ,  Reinhard Buettner

    IPC分类号： A61K39/395 ,  C07K16/18 ,  G01N33/574 ,  C07H21/00 ,  A61K31/70 ,  A61P43/00

    CPC分类号： G01N33/57434 ,  C07K16/3069 ,  C07K16/40 ,  G01N33/573 ,  G01N33/743 ,  G01N2500/00

    摘要： The invention relates to antibodies for use for modulating the activity of the lysine-specific demethylase (LSD1) in a mammal and to pharmaceutical and diagnostical compositions comprising such antibodies. The invention also relates to a method for identifying and/or scoring prostate carcinomas. Furthermore, the invention relates to the use of at least one siRNA (“short interfering RNA”) and/or at least one anti-LSD1 antibody for modulating the activity of the lysine-specific demethylase (LSD1) in a mammal or for the manufacture of a medicament for modulating the activity of the lysine-specific demethylase (LSD1) in a mammal. The invention also relates to a pharmaceutical composition for controlling the androgen receptor-dependent gene expression, comprising an effective dose of at least one siRNA and/or at least one anti-LSD1 antibody suitable for modulating the activity of the lysine-specific demethylase (LSD1) in a mammal. The invention also relates to a method for controlling the androgen receptor-dependent gene expression in a mammal, said process comprising the step of administering to said mammal, on a suitable route, an effective dose of a pharmaceutical composition modulating an activity of the lysine-specific demethylase (LSD1) in a mammal.

    摘要翻译： 本发明涉及用于调节哺乳动物中赖氨酸特异性脱甲基酶（LSD1）的活性的抗体以及包含此类抗体的药物和诊断组合物。 本发明还涉及用于鉴定和/或评分前列腺癌的方法。 此外，本发明涉及至少一种siRNA（“短干扰RNA”）和/或至少一种抗LSD1抗体用于调节哺乳动物或制造中的赖氨酸特异性脱甲基酶（LSD1）的活性的用途 的用于调节哺乳动物中赖氨酸特异性脱甲基酶（LSD1）的活性的药物。 本发明还涉及用于控制雄激素受体依赖性基因表达的药物组合物，其包含有效剂量的至少一种siRNA和/或至少一种抗LSD1抗体，其适于调节赖氨酸特异性脱甲基酶（LSD1 ）在哺乳动物中。 本发明还涉及一种用于控制哺乳动物中雄激素受体依赖性基因表达的方法，所述方法包括以下步骤：在合适的途径向所述哺乳动物施用有效剂量的调节赖氨酸 - 特异性脱甲基酶（LSD1）。