公开(公告)号：US5863903A

公开(公告)日：1999-01-26

申请号：US404077

申请日：1995-03-14

申请人： Karsten Lundgren ,  Ole Kirk

发明人： Karsten Lundgren ,  Ole Kirk

IPC分类号： C07D211/46 ,  C07H19/044 ,  C07H19/048 ,  C07D211/36 ,  A01N43/04 ,  C07D207/10 ,  C07H19/00

CPC分类号： C07H19/048 ,  C07D211/46 ,  C07H19/044 ,  Y10S514/866

摘要： The present invention relates to hydroxy alkyl piperidine compounds and pharmaceutical compositions thereof which can be used to treat diabetes.

摘要翻译： 本发明涉及可用于治疗糖尿病的羟基烷基哌啶化合物及其药物组合物。

公开(公告)号：US20070225212A1

公开(公告)日：2007-09-27

申请号：US11725262

申请日：2007-03-19

申请人： Suad Efendic ,  Mark Gutniak ,  Ole Kirk

发明人： Suad Efendic ,  Mark Gutniak ,  Ole Kirk

IPC分类号： A61K38/28

CPC分类号： A61K38/26

摘要： The invention employs GLP-1 (7-37), GLP-1(7-36)amide, and certain related compounds in combination with an oral hypoglycaemic agent for treating diabetes mellitus.

摘要翻译： 本发明使用GLP-1（7-37），GLP-1（7-36）酰胺和某些相关化合物与口服降血糖药联合用于治疗糖尿病。

公开(公告)号：US06805718B2

公开(公告)日：2004-10-19

申请号：US10375495

申请日：2003-02-27

申请人： Martin Barfoed ,  Ole Kirk ,  Sonja Salmon

发明人： Martin Barfoed ,  Ole Kirk ,  Sonja Salmon

IPC分类号： D06P132

CPC分类号： D06P1/0004 ,  D06P1/008 ,  D06P1/32 ,  D06P1/645 ,  D06P1/65118 ,  D06P3/08 ,  D06P3/14 ,  D06P3/30 ,  D06P3/305 ,  D06P3/32 ,  Y10S8/916

摘要： The present invention relates to methods of dyeing a material which involve contacting the material with a dyeing system which comprises: (a) a mixture of (i) an aromatic diamine and (ii) one or more of a naphthol and an aminonaphthalene and (b) an oxidation system comprising (i) a hydrogen peroxide source and an enzyme exhibiting peroxidase activity or (ii) an enzyme exibiting oxidase activity on one or more of the compounds of mixture (a). The material may be a fabric, yarn, fiber, garment or film made of fur, hide, leather, silk or wool, or made of cationic polysaccharide, cotton, diacetate, flax, linen, lyocel, polyacrylic, synthetic polyamide, polyester, ramie, rayon, triacetate, or viscose.

摘要翻译： 本发明涉及将材料与染色体系接触的材料的染色方法，其包括：（a）（i）芳族二胺和（ii）一种或多种萘酚和氨基萘的混合物和（b ）氧化系统，其包含（i）过氧化氢源和显示过氧化物酶活性的酶，或（ii）一种或多种混合物（a）化合物的酶脱氧氧化酶活性。 该材料可以是由毛皮，皮革，丝绸或羊毛制成的织物，纱线，纤维，衣服或薄膜，或由阳离子多糖，棉，二乙酸酯，亚麻，亚麻，水溶性，聚丙烯酸，合成聚酰胺，聚酯，苎麻 ，人造丝，三醋酸酯或粘胶。

公开(公告)号：US5700770A

公开(公告)日：1997-12-23

申请号：US447853

申请日：1995-05-23

申请人： Ture Damhus ,  Ole Kirk ,  Gitte Pedersen ,  Manuel Garcia Venegas

发明人： Ture Damhus ,  Ole Kirk ,  Gitte Pedersen ,  Manuel Garcia Venegas

IPC分类号： C07K14/32 ,  C07K14/795 ,  C11D3/00 ,  C11D3/386 ,  C12N9/08 ,  D06L3/02 ,  C11D3/395

CPC分类号： C12N9/0065 ,  C07K14/32 ,  C07K14/795 ,  C11D3/0021 ,  C11D3/38654 ,  D06L3/021

摘要： The transfer of a textile dye from a dyed fabric to another fabric during washing or rinsing is inhibited by adding an enzyme exhibiting peroxidase activity or an enzyme exhibiting a suitable oxidase activity to the wash liquor in which said fabrics are washed and/or rinsed. Peroxidase is produced extracellularly by some strains of Bacillus pumilus. The novel peroxidase preparation from B. pumilus is a microperoxidase, i.e. it contains hemopeptide as an active component. The preparation has improved stability at high temperature, at high pH and at high concentrations of hydrogen peroxide. It can be produced without undesired catalase activity.

摘要翻译： 在洗涤或漂洗中洗涤液中加入显示过氧化物酶活性的酶或显示出合适的氧化酶活性的酶，可以抑制纺织染料从染色织物转移到另一种织物。 过氧化物酶由一些短小芽孢杆菌菌株细胞外产生。 来自短小芽孢杆菌的新型过氧化物酶制剂是微过氧化物酶，即它含有血肽作为活性成分。 该制剂改善了高温下，高pH和高浓度过氧化氢的稳定性。 可以产生没有不需要的过氧化氢酶活性。

公开(公告)号：US5688757A

公开(公告)日：1997-11-18

申请号：US178593

申请日：1994-01-07

申请人： Ture Damhus ,  Ole Kirk ,  Frederick Edward Hardy

发明人： Ture Damhus ,  Ole Kirk ,  Frederick Edward Hardy

IPC分类号： C07H13/06 ,  C07H15/04 ,  C11D7/26 ,  C11D7/38 ,  C11D7/54

CPC分类号： C07H13/06 ,  C07H15/04

摘要： Certain sugar derivatives have bleach-activating effect both on "hydrophilic" stains (e.g. tea or red wine) and on "hydrophobic" stains (e.g. grass or tomato sauce). The compounds in question are derivatives of pentoses or hexoses, having a long-chain acyl group and one or more short-chain acyl or aroyl groups attached through ester bonds. Optionally, a short-chain alkyl group is attached through a glycosidic bond. These compounds are non-toxic and biodegradable, and can conveniently be prepared by methods known in the art.

摘要翻译： 某些糖衍生物对“亲水”污渍（例如茶或红葡萄酒）和“疏水性”污渍（例如草或番茄酱）都具有漂白活化作用。 所讨论的化合物是戊糖或己糖的衍生物，具有长链酰基和通过酯键连接的一个或多个短链酰基或芳酰基。 任选地，短链烷基通过糖苷键连接。 这些化合物是无毒的和可生物降解的，并且可以方便地通过本领域已知的方法制备。

公开(公告)号：US5541092A

公开(公告)日：1996-07-30

申请号：US204693

申请日：1994-03-01

申请人： Ole Kirk ,  Frederik Bj orkling ,  Sven Erik Godtfredsen

发明人： Ole Kirk ,  Frederik Bj orkling ,  Sven Erik Godtfredsen

IPC分类号： C12P7/40 ,  C12P7/00 ,  C12P11/00 ,  C12P13/00

CPC分类号： C12P7/40

摘要： A process for the preparation of a peroxycarboxylic acid of general formula (I), wherein R is an organic residue, in particular a linear or branched alkyled group, an aryl group or an alkyl aryl group each of which is optionally substituted with one or more groups, the process comprising treating a carboxylic acid of the general formula R--COOH, wherein R has the meaning indicated above, with hydrogen peroxide or a precursor thereof in the presence of an enzyme catalyst is described. The enzyme catalyst is preferably a hydrolase, such as a protease or a lipase. Also, a process for the oxidation of organic compounds with the peroxycarboxylic acids thus prepared is described.

摘要翻译： 一种制备通式（I）的过氧羧酸的方法，其中R是有机残基，特别是直链或支链烷基，芳基或烷基芳基，其各自任选被一个或多个 描述了在酶催化剂存在下用过氧化氢或其前体处理其中R具有上述含义的通式R-COOH的羧酸的方法。 酶催化剂优选为水解酶，如蛋白酶或脂肪酶。 此外，描述了用如此制备的过氧羧酸氧化有机化合物的方法。

公开(公告)号：US5534435A

公开(公告)日：1996-07-09

申请号：US390351

申请日：1995-02-08

申请人： Sven E. Godtfredsen ,  Ole Kirk ,  Ture Damhus

发明人： Sven E. Godtfredsen ,  Ole Kirk ,  Ture Damhus

IPC分类号： C12P7/40

CPC分类号： C12P7/40

摘要： The invention relates to a process for converting peroxycarboxylic acids to carboxylic acids, the process comprising treating a peroxycarboxylic acid of the general formula I:R--CO--OOH (I)wherein R is a linear or branched alkyl group, an aryl group or an aryl-alkyl group each of which may optionally be substituted with one or more hydroxy, halogen, alkoxy, amino, alkylamino, sulfo, sulfoxy, sulfono, amido, carboxy, percarboxy or nitro groups, with an enzyme catalyst to form the corresponding carboxylic acid of the general formula II:R--CO--OH (II)wherein R has the meaning indicated above.

摘要翻译： 本发明涉及将过氧羧酸转化为羧酸的方法，该方法包括处理通式I的过氧羧酸：其中R是直链或支链烷基，芳基或 芳基 - 烷基，其各自可以任选地被一个或多个羟基，卤素，烷氧基，氨基，烷基氨基，磺基，磺酰氧基，磺酰基，氨基，羧基，羧基或硝基取代，与酶催化剂一起形成相应的羧酸 的通式II：R-CO-OH（II）其中R具有上述含义。

公开(公告)号：US06326186B1

公开(公告)日：2001-12-04

申请号：US09416976

申请日：1999-10-13

申请人： Ole Kirk ,  Anders Ohmann

发明人： Ole Kirk ,  Anders Ohmann

IPC分类号： B09B300

CPC分类号： A01N47/36 ,  A01N25/32 ,  A01N2300/00

摘要： A method has been found for reducing amino acid biosynthesis inhibiting effect of a sulfonyl-urea based compound of the general formula: comprising contacting in an aqueous solution said sulfonyl-urea based compound with an enzyme capable of reducing said amino acid biosynthesis inhibiting effect.

摘要翻译： 已经发现了用于降低通式为磺酰脲类化合物的氨基酸生物合成抑制作用的方法：包括使所述基于磺酰脲的化合物的水溶液与能够降低所述氨基酸生物合成抑制作用的酶接触。

公开(公告)号：USRE37302E1

公开(公告)日：2001-07-31

申请号：US09025951

申请日：1998-02-19

申请人： Suad Efendic ,  Mark Gutniak ,  Ole Kirk

发明人： Suad Efendic ,  Mark Gutniak ,  Ole Kirk

IPC分类号： A61K3800

CPC分类号： A61K38/26 ,  A61K2300/00

摘要： The invention employs GLP-1(7-37), GLP-1(7-36)amide, and certain related compounds in combination with an oral hypoglycaemic agent for treating diabetes mellitus.

摘要翻译： 本发明使用GLP-1（7-37），GLP-1（7-36）酰胺和某些相关化合物与口服降血糖药联合用于治疗糖尿病。

公开(公告)号：US6156548A

公开(公告)日：2000-12-05

申请号：US210192

申请日：1998-12-11

申请人： Morten Wurtz Christensen ,  Ole Kirk ,  Christian Pedersen

发明人： Morten Wurtz Christensen ,  Ole Kirk ,  Christian Pedersen

IPC分类号： C12N11/00 ,  C12N11/08 ,  C12N11/14 ,  C12P7/64

CPC分类号： C12N11/08 ,  C12N11/00 ,  C12N11/14

摘要： An immobilized enzyme preparation for use in an organic medium essentially devoid of free water is prepared using a fluidized bed. An enzyme-containing liquid medium is contacted with a particulate porous carrier which preferably has a particle size of 200-1000 .mu.m and a surface area of 20-1000 m.sup.2 /g, and volatile components of the liquid medium are removed to fix or adsorb the enzyme on the carrier. The carrier may have a hydrophilic surface and an amount of liquid medium is used to prevent agglomeration of the carrier. The enzyme can be adsorbed on a carrier having a hydrophobic surface, and the addition of a hygroscopic substance suppresses agglomeration of the carrier by absorbing excess liquid. The hygroscopic substance may be removed during the removal of volatile components. Contacting of the enzyme-containing liquid and carrier is in a fluidized bed where immobilization and removing volatile components are conducted simultaneously, or contacting is in mixer followed by removing volatile components in a fluidized bed. The enzyme-containing liquid may be atomized onto the carrier in the fluidized bed or in the mixer. Enzymes immobilized include lipase, and the immobilized lipase is used in a trans-esterification reaction.

摘要翻译： 使用流化床制备用于基本上不含游离水的有机介质中的固定化酶制剂。 将含酶液体介质与优选粒径为200-1000μm，表面积为20-1000m 2 / g的颗粒状多孔载体接触，除去液体介质的挥发性成分以固定或吸附 载体上的酶。 载体可以具有亲水表面，并且使用一定量的液体介质来防止载体的附聚。 酶可以吸附在具有疏水性表面的载体上，并且吸湿性物质的添加通过吸收多余的液体来抑制载体的聚集。 在去除挥发性组分期间可以除去吸湿性物质。 含酶液体和载体的接触在流化床中，其中同时进行固定和除去挥发性组分，或者在混合器中接触，然后在流化床中除去挥发性组分。 含酶液体可以在流化床或混合器中雾化到载体上。 固定的酶包括脂肪酶，并且固定的脂肪酶用于酯交换反应。