公开(公告)号：US20110173708A1

公开(公告)日：2011-07-14

申请号：US13031009

申请日：2011-02-18

申请人： Katherin E. Combs ,  Ling Ling Culbertson ,  Juan Delmas-Mata ,  Frederic de Sauvage ,  Liangfen Fan ,  Gretchen Frantz ,  Leslie Jane Green ,  Erin Marie Massey ,  Dina Rebecca McLain ,  Charles Montgomery ,  Bobby Joe Payne ,  Franklin Peale ,  Heidi Phillips ,  Michelle Rohrer ,  Tracy Ellen Willis Sevaux ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Joy Anne Stala ,  Tracy Tzu-Ling Tang ,  Ching-Yun Wang ,  Wen Xiong ,  Peter Vogel

发明人： Katherin E. Combs ,  Ling Ling Culbertson ,  Juan Delmas-Mata ,  Frederic de Sauvage ,  Liangfen Fan ,  Gretchen Frantz ,  Leslie Jane Green ,  Erin Marie Massey ,  Dina Rebecca McLain ,  Charles Montgomery ,  Bobby Joe Payne ,  Franklin Peale ,  Heidi Phillips ,  Michelle Rohrer ,  Tracy Ellen Willis Sevaux ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Joy Anne Stala ,  Tracy Tzu-Ling Tang ,  Ching-Yun Wang ,  Wen Xiong ,  Peter Vogel

IPC分类号： G01N33/00

CPC分类号： C12N15/8509 ,  A01K2217/075 ,  A01K2267/0306 ,  A01K2267/0362 ,  A01K2267/0375

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO226, PRO257, PRO268, PRO290, PRO36006, PRO363, PRO365, PRO382, PRO444, PRO705, PRO1071, PRO1125, PRO1134, PRO1155, PRO1281, PRO1343, PRO1379, PRO1380, PRO1387, PRO1419, PRO1433, PRO1474, PRO1550, PRO1571, PRO1572, PRO1759, PRO1904, PRO35193, PRO4341, PRO4348, PRO4369, PRO4381, PRO4407, PRO4425, PRO4985, PRO4989, PRO5737, PRO5800, PRO5993, PRO6017, PRO7174, PRO9744, PRO9821, PRO9852, PRO9873, PRO10196, PRO34778, PRO20233, PRO21956, PRO57290, PRO38465, PRO38683 or PRO85161 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地，本发明提供转基因小鼠，其包括在PRO226，​​PRO257，PRO268，PRO290，PRO36006，PRO363，PRO365，PRO382，PRO444，PRO705，PRO1071，PRO1125，PRO1134，PRO1155，PRO1281，PRO1343，PRO1379，PRO1380，PRO1387，PRO1419中的中断 ，PRO1433，PRO1474，PRO1550，PRO1571，PRO1572，PRO1759，PRO1904，PRO35193，PRO4341，PRO4348，PRO4369，PRO4381，PRO4407，PRO4425，PRO4985，PRO4989，PRO5737，PRO5800，PRO5993，PRO6017，PRO7174，PRO9744，PRO9821，PRO9852，PRO9873 ，PRO10196，PRO34778，PRO20233，PRO21956，PRO57290，PRO38465，PRO38683或PRO85161基因。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。

公开(公告)号：US20120272341A1

公开(公告)日：2012-10-25

申请号：US13473322

申请日：2012-05-16

申请人： Katherin E. Combs ,  Ling Ling Culbertson ,  Juan Delmas-Mata ,  Frederic de Sauvage ,  Liangfen Fan ,  Gretchen Frantz ,  Leslie Jane Green ,  Erin Marie Massey ,  Dina Rebecca McLain ,  Charles Montgomery ,  Bobby Joe Payne ,  Franklin Peale ,  Heidi Phillips ,  Michelle Rohrer ,  Tracy Ellen Willis Sevaux ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Joy Anne Stala ,  Tracy Tzu-Ling Tang ,  Ching-Yun Wang ,  Wen Xiong ,  Peter Vogel

发明人： Katherin E. Combs ,  Ling Ling Culbertson ,  Juan Delmas-Mata ,  Frederic de Sauvage ,  Liangfen Fan ,  Gretchen Frantz ,  Leslie Jane Green ,  Erin Marie Massey ,  Dina Rebecca McLain ,  Charles Montgomery ,  Bobby Joe Payne ,  Franklin Peale ,  Heidi Phillips ,  Michelle Rohrer ,  Tracy Ellen Willis Sevaux ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Joy Anne Stala ,  Tracy Tzu-Ling Tang ,  Ching-Yun Wang ,  Wen Xiong ,  Peter Vogel

IPC分类号： G01N33/50 ,  C12Q1/02 ,  G01N33/92 ,  G01N33/483

CPC分类号： C12N15/8509 ,  A01K2217/075 ,  A01K2267/0306 ,  A01K2267/0362 ,  A01K2267/0375

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO226, PRO257, PRO268, PRO290, PRO36006, PRO363, PRO365, PRO382, PRO444, PRO705, PRO1071, PRO1125, PRO1134, PRO1155, PRO1281, PRO1343, PRO1379, PRO1380, PRO1387, PRO1419, PRO1433, PRO1474, PRO1550, PRO1571, PRO1572, PRO1759, PRO1904, PRO35193, PRO4341, PRO4348, PRO4369, PRO4381, PRO4407, PRO4425, PRO4985, PRO4989, PRO5737, PRO5800, PRO5993, PRO6017, PRO7174, PRO9744, PRO9821, PRO9852, PRO9873, PRO10196, PRO34778, PRO20233, PRO21956, PRO57290, PRO38465, PRO38683 or PRO85161 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地，本发明提供转基因小鼠，其包括在PRO226，​​PRO257，PRO268，PRO290，PRO36006，PRO363，PRO365，PRO382，PRO444，PRO705，PRO1071，PRO1125，PRO1134，PRO1155，PRO1281，PRO1343，PRO1379，PRO1380，PRO1387，PRO1419中的中断 ，PRO1433，PRO1474，PRO1550，PRO1571，PRO1572，PRO1759，PRO1904，PRO35193，PRO4341，PRO4348，PRO4369，PRO4381，PRO4407，PRO4425，PRO4985，PRO4989，PRO5737，PRO5800，PRO5993，PRO6017，PRO7174，PRO9744，PRO9821，PRO9852，PRO9873 ，PRO10196，PRO34778，PRO20233，PRO21956，PRO57290，PRO38465，PRO38683或PRO85161基因。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。

公开(公告)号：US20080124344A1

公开(公告)日：2008-05-29

申请号：US11814549

申请日：2006-07-18

申请人： Katherin E. Combs ,  Ling Ling Culbertson ,  Juan Delmas-Mata ,  Frederic de Sauvage ,  Liangfen Fan ,  Gretchen Frantz ,  Leslie Jane Green ,  Erin Marie Massey ,  Dina Rebecca McLain ,  Charles Montgomery ,  Bobby Joe Payne ,  Franklin Peale ,  Heidi Phillips ,  Michelle Rohrer ,  Tracy E.W. Sevaux ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Joy Anne Stala ,  Tracy Tzu-Ling Tang ,  Ching-Yun Wang ,  Wen Xiong ,  Peter Vogel

发明人： Katherin E. Combs ,  Ling Ling Culbertson ,  Juan Delmas-Mata ,  Frederic de Sauvage ,  Liangfen Fan ,  Gretchen Frantz ,  Leslie Jane Green ,  Erin Marie Massey ,  Dina Rebecca McLain ,  Charles Montgomery ,  Bobby Joe Payne ,  Franklin Peale ,  Heidi Phillips ,  Michelle Rohrer ,  Tracy E.W. Sevaux ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Joy Anne Stala ,  Tracy Tzu-Ling Tang ,  Ching-Yun Wang ,  Wen Xiong ,  Peter Vogel

IPC分类号： A61K39/395 ,  A01K67/00 ,  A61P43/00

CPC分类号： C12N15/8509 ,  A01K2217/075 ,  A01K2267/0306 ,  A01K2267/0362 ,  A01K2267/0375

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO226, PRO257, PRO268, PRO290, PRO36006, PRO363, PRO365, PRO382, PRO444, PRO705, PRO1071, PRO1125, PRO1134, PRO1155, PRO1281, PRO1343, PRO1379, PRO1380, PRO1387, PRO1419, PRO1433, PRO1474, PRO1550, PRO1571, PRO1572, PRO1759, PRO1904, PRO35193, PRO4341, PRO4348, PRO4369, PRO4381, PRO4407, PRO4425, PRO4985, PRO4989, PRO5737, PRO5800, PRO5993, PRO6017, PRO7174, PRO9744, PRO9821, PRO9852, PRO9873, PRO10196, PRO34778, PRO20233, PRO21956, PRO57290, PRO38465, PRO38683 or PRO85161 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地，本发明提供转基因小鼠，其包括在PRO226，​​PRO257，PRO268，PRO290，PRO36006，PRO363，PRO365，PRO382，PRO444，PRO705，PRO1071，PRO1125，PRO1134，PRO1155，PRO1281，PRO1343，PRO1379，PRO1380，PRO1387，PRO1419中的中断 ，PRO1433，PRO1474，PRO1550，PRO1571，PRO1572，PRO1759，PRO1904，PRO35193，PRO4341，PRO4348，PRO4369，PRO4381，PRO4407，PRO4425，PRO4985，PRO4989，PRO5737，PRO5800，PRO5993，PRO6017，PRO7174，PRO9744，PRO9821，PRO9852，PRO9873 ，PRO10196，PRO34778，PRO20233，PRO21956，PRO57290，PRO38465，PRO38683或PRO85161基因。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。

公开(公告)号：US07931902B2

公开(公告)日：2011-04-26

申请号：US11814549

申请日：2006-07-18

申请人： Frederic J. de Sauvage ,  Gretchen Frantz ,  Charles Montgomery ,  Franklin Peale ,  Zheng-Zheng Shi ,  Mary Jean Sparks

发明人： Frederic J. de Sauvage ,  Gretchen Frantz ,  Charles Montgomery ,  Franklin Peale ,  Zheng-Zheng Shi ,  Mary Jean Sparks

IPC分类号： A01K67/00 ,  A61K39/395 ,  A61P43/00

CPC分类号： C12N15/8509 ,  A01K2217/075 ,  A01K2267/0306 ,  A01K2267/0362 ,  A01K2267/0375

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO226, PRO257, PRO268, PRO290, PRO36006, PRO363, PRO365, PRO382, PRO444, PRO705, PRO1071, PRO1125, PRO1134, PRO1155, PRO1281, PRO1343, PRO1379, PRO1380, PRO1387, PRO1419, PRO1433, PRO1474, PRO1550, PRO1571, PRO1572, PRO1759, PRO1904, PRO35193, PRO4341, PRO4348, PRO4369, PRO4381, PRO4407, PRO4425, PRO4985, PRO4989, PRO5737, PRO5800, PRO5993, PRO6017, PRO7174, PRO9744, PRO9821, PRO9852, PRO9873, PRO10196, PRO34778, PRO20233, PRO21956, PRO57290, PRO38465, PRO38683 or PRO85161 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地，本发明提供转基因小鼠，其包括在PRO226，​​PRO257，PRO268，PRO290，PRO36006，PRO363，PRO365，PRO382，PRO444，PRO705，PRO1071，PRO1125，PRO1134，PRO1155，PRO1281，PRO1343，PRO1379，PRO1380，PRO1387，PRO1419中的中断 ，PRO1433，PRO1474，PRO1550，PRO1571，PRO1572，PRO1759，PRO1904，PRO35193，PRO4341，PRO4348，PRO4369，PRO4381，PRO4407，PRO4425，PRO4985，PRO4989，PRO5737，PRO5800，PRO5993，PRO6017，PRO7174，PRO9744，PRO9821，PRO9852，PRO9873 ，PRO10196，PRO34778，PRO20233，PRO21956，PRO57290，PRO38465，PRO38683或PRO85161基因。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。

公开(公告)号：US20060251662A1

公开(公告)日：2006-11-09

申请号：US11418347

申请日：2006-05-04

申请人： Wesley Chang ,  Frederic de Sauvage ,  Dan Eaton ,  Allen Ebens ,  Gretchen Frantz ,  Jo-Anne Hongo ,  Hartmut Koeppen ,  Andrew Polson ,  Victoria Smith

发明人： Wesley Chang ,  Frederic de Sauvage ,  Dan Eaton ,  Allen Ebens ,  Gretchen Frantz ,  Jo-Anne Hongo ,  Hartmut Koeppen ,  Andrew Polson ,  Victoria Smith

IPC分类号： G01N33/574 ,  A61K39/395 ,  A61K48/00

CPC分类号： C07K16/3061

摘要： The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.

公开(公告)号：US20050226869A1

公开(公告)日：2005-10-13

申请号：US11020508

申请日：2004-12-21

申请人： Wesley Chang ,  Dan Eaton ,  Allen Ebens ,  Frederic de Sauvage ,  Gretchen Frantz ,  Jo-Anne Hongo ,  Hartmut Koeppen ,  Andrew Polson ,  Victoria Smith

发明人： Wesley Chang ,  Dan Eaton ,  Allen Ebens ,  Frederic de Sauvage ,  Gretchen Frantz ,  Jo-Anne Hongo ,  Hartmut Koeppen ,  Andrew Polson ,  Victoria Smith

IPC分类号： A61K39/395 ,  A61K48/00 ,  C07K14/705 ,  C07K16/30

CPC分类号： C07K14/705 ,  A61K2039/505 ,  C07K16/30

摘要： The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.

公开(公告)号：US20090075279A1

公开(公告)日：2009-03-19

申请号：US12156180

申请日：2008-05-29

申请人： Gretchen Frantz ,  Kenneth J. Hillan ,  Heidi Phillips ,  Paul Polakis ,  Susan D. Spencer ,  P. Mickey Williams ,  Thomas D. Wu ,  Zemin Wang

发明人： Gretchen Frantz ,  Kenneth J. Hillan ,  Heidi Phillips ,  Paul Polakis ,  Susan D. Spencer ,  P. Mickey Williams ,  Thomas D. Wu ,  Zemin Wang

IPC分类号： G01N33/574 ,  C12Q1/68

CPC分类号： C07K14/4748 ,  A61K47/6803 ,  A61K47/6809 ,  A61K47/6843 ,  A61K47/6851 ,  A61K2039/505 ,  C07K14/705 ,  C07K14/71 ,  C07K16/18 ,  C07K16/30 ,  G01N33/574

摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

公开(公告)号：US20090017473A1

公开(公告)日：2009-01-15

申请号：US12156218

申请日：2008-05-29

申请人： Gretchen Frantz ,  Kenneth J. Hillan ,  Heidi Phillips ,  Paul Polakis ,  Susan D. Spencer ,  P. Mickey Williams ,  Thomas D. Wu ,  Zemin Zhang

发明人： Gretchen Frantz ,  Kenneth J. Hillan ,  Heidi Phillips ,  Paul Polakis ,  Susan D. Spencer ,  P. Mickey Williams ,  Thomas D. Wu ,  Zemin Zhang

IPC分类号： G01N33/574

CPC分类号： C07K14/4748 ,  A61K47/6803 ,  A61K47/6809 ,  A61K47/6843 ,  A61K47/6851 ,  A61K2039/505 ,  C07K14/705 ,  C07K14/71 ,  C07K16/18 ,  C07K16/30 ,  G01N33/574

摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

公开(公告)号：US20070219350A1

公开(公告)日：2007-09-20

申请号：US11801111

申请日：2007-05-07

申请人： Gretchen Frantz ,  Kenneth Hillan ,  Heidi Phillips ,  Paul Polakis ,  Susan Spencer ,  P. Williams ,  Thomas Wu ,  Zemin Zhang

发明人： Gretchen Frantz ,  Kenneth Hillan ,  Heidi Phillips ,  Paul Polakis ,  Susan Spencer ,  P. Williams ,  Thomas Wu ,  Zemin Zhang

IPC分类号： C07K2/00

CPC分类号： C07K14/4748

摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

公开(公告)号：US20060160997A1

公开(公告)日：2006-07-20

申请号：US11248718

申请日：2005-10-11

申请人： Belinda Cairns ,  Ruihuan Chen ,  Gretchen Frantz ,  Kenneth Hillan ,  Hartmut Koeppen ,  Heidi Phillips ,  Paul Polakis ,  Susan Spencer ,  Victoria Smith ,  P. Williams ,  Thomas Wu ,  Zemin Zhang

发明人： Belinda Cairns ,  Ruihuan Chen ,  Gretchen Frantz ,  Kenneth Hillan ,  Hartmut Koeppen ,  Heidi Phillips ,  Paul Polakis ,  Susan Spencer ,  Victoria Smith ,  P. Williams ,  Thomas Wu ,  Zemin Zhang

IPC分类号： C07K16/30

CPC分类号： C07K16/18 ,  A61K47/6803 ,  A61K47/6809 ,  A61K47/6843 ,  A61K47/6851 ,  A61K2039/505 ,  C07K16/30 ,  C07K16/3023 ,  C07K16/40 ,  C07K2317/73 ,  G01N33/57407

摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.