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9 条记录 (耗时 0.071 秒)

    Gene disruptions, compositions and methods relating thereto
    1.
    发明授权
    Gene disruptions, compositions and methods relating thereto 失效
    基因破坏，组合物和方法

    公开(公告)号：US07931902B2

    公开(公告)日：2011-04-26

    申请号：US11814549

    申请日：2006-07-18

    申请人： Frederic J. de Sauvage ,  Gretchen Frantz ,  Charles Montgomery ,  Franklin Peale ,  Zheng-Zheng Shi ,  Mary Jean Sparks

    发明人： Frederic J. de Sauvage ,  Gretchen Frantz ,  Charles Montgomery ,  Franklin Peale ,  Zheng-Zheng Shi ,  Mary Jean Sparks

    IPC分类号： A01K67/00 ,  A61K39/395 ,  A61P43/00

    CPC分类号： C12N15/8509 ,  A01K2217/075 ,  A01K2267/0306 ,  A01K2267/0362 ,  A01K2267/0375

    摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO226, PRO257, PRO268, PRO290, PRO36006, PRO363, PRO365, PRO382, PRO444, PRO705, PRO1071, PRO1125, PRO1134, PRO1155, PRO1281, PRO1343, PRO1379, PRO1380, PRO1387, PRO1419, PRO1433, PRO1474, PRO1550, PRO1571, PRO1572, PRO1759, PRO1904, PRO35193, PRO4341, PRO4348, PRO4369, PRO4381, PRO4407, PRO4425, PRO4985, PRO4989, PRO5737, PRO5800, PRO5993, PRO6017, PRO7174, PRO9744, PRO9821, PRO9852, PRO9873, PRO10196, PRO34778, PRO20233, PRO21956, PRO57290, PRO38465, PRO38683 or PRO85161 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

    摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地，本发明提供转基因小鼠，其包括在PRO226，​​PRO257，PRO268，PRO290，PRO36006，PRO363，PRO365，PRO382，PRO444，PRO705，PRO1071，PRO1125，PRO1134，PRO1155，PRO1281，PRO1343，PRO1379，PRO1380，PRO1387，PRO1419中的中断 ，PRO1433，PRO1474，PRO1550，PRO1571，PRO1572，PRO1759，PRO1904，PRO35193，PRO4341，PRO4348，PRO4369，PRO4381，PRO4407，PRO4425，PRO4985，PRO4989，PRO5737，PRO5800，PRO5993，PRO6017，PRO7174，PRO9744，PRO9821，PRO9852，PRO9873 ，PRO10196，PRO34778，PRO20233，PRO21956，PRO57290，PRO38465，PRO38683或PRO85161基因。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。

    METHODS FOR THE TREATMENT OF CARCINOMA
    6.
    发明申请
    METHODS FOR THE TREATMENT OF CARCINOMA 审中-公开

    公开(公告)号：US20070141068A1

    公开(公告)日：2007-06-21

    申请号：US11671987

    申请日：2007-02-06

    申请人： Mary Gerritsen ,  Franklin Peale ,  Thomas Wu

    发明人： Mary Gerritsen ,  Franklin Peale ,  Thomas Wu

    IPC分类号： A61K39/395 ,  C07K16/30

    CPC分类号： G01N33/57438 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/82 ,  C07K16/30 ,  C07K16/3076 ,  G01N33/57484 ,  G01N2333/726 ,  G01N2500/00

    摘要： The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of genes that are amplified in the genome of tumor cells, such as renal cell carcinoma. Such gene amplification is expected to be associated with the overexpression of the gene product as compared to normal cells of the same tissue type and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, such as renal cell carcinoma, and may act as predictors of the prognosis of tumor treatment. The present invention is directed to novel methods of diagnosing and treating tumor, such as renal cell carcinoma or Wilms tumor.

    METHODS FOR THE TREATMENT OF CARCINOMA
    7.
    发明申请
    METHODS FOR THE TREATMENT OF CARCINOMA 审中-公开
    治疗癌症的方法

    公开(公告)号：US20070020276A1

    公开(公告)日：2007-01-25

    申请号：US11530830

    申请日：2006-09-11

    申请人： Mary Gerritsen ,  Franklin Peale ,  Thomas Wu

    发明人： Mary Gerritsen ,  Franklin Peale ,  Thomas Wu

    IPC分类号： A61K39/395 ,  G01N33/574 ,  C07H21/04 ,  C12P21/06 ,  C12N5/06 ,  C07K16/30

    CPC分类号： G01N33/57438 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/82 ,  C07K16/30 ,  C07K16/3076 ,  G01N33/57484 ,  G01N2333/726 ,  G01N2500/00

    摘要： The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of genes that are amplified in the genome of tumor cells, such as renal cell carcinoma. Such gene amplification is expected to be associated with the overexpression of the gene product as compared to normal cells of the same tissue type and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, such as renal cell carcinoma, and may act as predictors of the prognosis of tumor treatment. The present invention is directed to novel methods of diagnosing and treating tumor, such as renal cell carcinoma or Wilms tumor.

    摘要翻译： 本发明涉及用于诊断和治疗哺乳动物包括人类的肿瘤细胞生长和增殖的组合物和方法。 本发明基于在肿瘤细胞如肾细胞癌基因组中扩增的基因的鉴定。 预期这种基因扩增与相同组织类型的正常细胞相比，与基因产物的过表达有关，并且有助于肿瘤发生。 因此，由扩增的基因编码的蛋白质被认为是某些癌症如肾细胞癌的诊断和/或治疗（包括预防）的有用靶标，并且可以作为肿瘤治疗预后的预测因子。 本发明涉及新型的诊断和治疗肿瘤的方法，例如肾细胞癌或Wilms肿瘤。

    METHODS FOR THE TREATMENT OF CARCINOMA
    8.
    发明申请
    METHODS FOR THE TREATMENT OF CARCINOMA 审中-公开
    治疗癌症的方法

    公开(公告)号：US20070026450A1

    公开(公告)日：2007-02-01

    申请号：US11535366

    申请日：2006-09-26

    申请人： Mary Gerritsen ,  Franklin Peale ,  Thomas Wu

    发明人： Mary Gerritsen ,  Franklin Peale ,  Thomas Wu

    IPC分类号： C12Q1/68 ,  G01N33/574 ,  C12P21/06 ,  C12N5/06 ,  C07K16/40 ,  C07K16/30

    CPC分类号： C07K16/2866

    摘要： The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of genes that are amplified in the genome of tumor cells, such as renal cell carcinoma. Such gene amplification is expected to be associated with the overexpression of the gene product as compared to normal cells of the same tissue type and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, such as renal cell carcinoma, and may act as predictors of the prognosis of tumor treatment. The present invention is directed to novel methods of diagnosing and treating tumor, such as renal cell carcinoma.

    摘要翻译： 本发明涉及用于诊断和治疗哺乳动物包括人类的肿瘤细胞生长和增殖的组合物和方法。 本发明基于在肿瘤细胞如肾细胞癌基因组中扩增的基因的鉴定。 预期这种基因扩增与相同组织类型的正常细胞相比，与基因产物的过表达有关，并且有助于肿瘤发生。 因此，由扩增的基因编码的蛋白质被认为是某些癌症如肾细胞癌的诊断和/或治疗（包括预防）的有用靶标，并且可以作为肿瘤治疗预后的预测因子。 本发明涉及新型的诊断和治疗肿瘤的方法，如肾细胞癌。