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公开(公告)号：US20100204741A1
公开(公告)日：2010-08-12
申请号：US12537019
申请日：2009-08-06
IPC分类号： A61N1/36
CPC分类号： A61N1/36117 , A61N1/36053 , A61N1/36114 , A61N1/36139 , A61N1/37211 , A61N1/3787
摘要： A method and apparatus for treating a condition associated with impaired blood pressure and/or heart rate in a subject comprising applying an electrical treatment signal, wherein the electrical treatment signal is selected to at least partially block nerve impulses, or in some embodiments, to augment nerve impulses.
摘要翻译： 一种用于治疗与受试者的血压和/或心率受损相关的病症的方法和装置，包括施加电治疗信号，其中所述电治疗信号被选择为至少部分阻断神经冲动，或在一些实施例中增加 神经冲动
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公开(公告)号：US08768469B2
公开(公告)日：2014-07-01
申请号：US12537019
申请日：2009-08-06
IPC分类号： A61N1/00
CPC分类号： A61N1/36117 , A61N1/36053 , A61N1/36114 , A61N1/36139 , A61N1/37211 , A61N1/3787
摘要： A method and apparatus for treating a condition associated with impaired blood pressure and/or heart rate in a subject comprising applying an electrical treatment signal, wherein the electrical treatment signal is selected to at least partially block nerve impulses, or in some embodiments, to augment nerve impulses.
摘要翻译： 一种用于治疗与受试者中受损的血压和/或心率相关的病症的方法和装置，包括施加电治疗信号，其中所述电治疗信号被选择为至少部分阻断神经冲动，或在一些实施例中增加 神经冲动
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公开(公告)号：US20090254143A1
公开(公告)日：2009-10-08
申请号：US12417918
申请日：2009-04-03
申请人： Katherine S. Tweden , Mark B. Knudson , Richard R. Wilson , Arnold W. Thornton , Dennis Dong-won Kim
发明人： Katherine S. Tweden , Mark B. Knudson , Richard R. Wilson , Arnold W. Thornton , Dennis Dong-won Kim
IPC分类号： A61N1/36
CPC分类号： A61N1/36053 , A61M5/00 , A61N1/0551 , A61N1/36007 , A61N1/36167 , A61N1/37211 , A61N1/37235
摘要： Various methods and apparatus for treating a condition associated with impaired glucose regulation in a subject comprising in one embodiment, applying a neural conduction block to a target nerve at a blocking site with the neural conduction block selected to at least partially block nerve pulses. In another embodiment, combinations of down-regulating and or up-regulating with or without pharmaceutical agents are used to treat impaired glucose regulation. In other embodiments, up-regulation or down-regulation of various nerves, such as the vagus and its branches, and the splanchnic is used to modify the production of GLP-1 and GIP, thereby controlling glucose levels. In yet further embodiments, combinations of down-regulating and or up-regulating with or without pharmaceutical agents are used to modify the production of GLP-1 and GIP, to treat impaired glucose regulation.
摘要翻译： 用于治疗与受试者中的葡萄糖调节受损有关的病症的各种方法和装置包括在一个实施方案中，将神经传导阻滞物施用于至少部分阻断神经脉冲的神经传导阻滞位置处的阻断部位的靶神经。 在另一个实施方案中，下调和/或上调与或不与药剂的组合用于治疗葡萄糖调节受损。 在其他实施方案中，使用诸如迷走神经及其分支以及内脏的各种神经的上调或下调来改变GLP-1和GIP的产生，从而控制葡萄糖水平。 在另外的实施方案中，使用具有或不具有药剂的下调和/或上调的组合来改变GLP-1和GIP的产生，以治疗葡萄糖调节受损。
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公开(公告)号：US08483830B2
公开(公告)日：2013-07-09
申请号：US12417918
申请日：2009-04-03
申请人： Katherine S. Tweden , Mark B. Knudson , Richard R. Wilson , Arnold W. Thornton , Dennis Dong-won Kim
发明人： Katherine S. Tweden , Mark B. Knudson , Richard R. Wilson , Arnold W. Thornton , Dennis Dong-won Kim
IPC分类号： A61N1/05
CPC分类号： A61N1/36053 , A61M5/00 , A61N1/0551 , A61N1/36007 , A61N1/36167 , A61N1/37211 , A61N1/37235
摘要： Various methods and apparatus for treating a condition associated with impaired glucose regulation in a subject comprising in one embodiment, applying a neural conduction block to a target nerve at a blocking site with the neural conduction block selected to at least partially block nerve pulses. In another embodiment, combinations of down-regulating and or up-regulating with or without pharmaceutical agents are used to treat impaired glucose regulation. In other embodiments, up-regulation or down-regulation of various nerves, such as the vagus and its branches, and the splanchnic is used to modify the production of GLP-1 and GIP, thereby controlling glucose levels. In yet further embodiments, combinations of down-regulating and or up-regulating with or without pharmaceutical agents are used to modify the production of GLP-1 and GIP, to treat impaired glucose regulation.
摘要翻译： 用于治疗与受试者中的葡萄糖调节受损有关的病症的各种方法和装置包括在一个实施方案中，将神经传导阻滞物施用于至少部分阻断神经脉冲的神经传导阻滞位置处的阻断部位的靶神经。 在另一个实施方案中，下调和/或上调与或不与药剂的组合用于治疗葡萄糖调节受损。 在其他实施方案中，使用诸如迷走神经及其分支以及内脏的各种神经的上调或下调来改变GLP-1和GIP的产生，从而控制葡萄糖水平。 在另外的实施方案中，使用具有或不具有药剂的下调和/或上调的组合来改变GLP-1和GIP的产生，以治疗葡萄糖调节受损。
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公开(公告)号：US08010204B2
公开(公告)日：2011-08-30
申请号：US12721603
申请日：2010-03-11
IPC分类号： A61N1/08
CPC分类号： A61N1/36007 , A61N1/05 , A61N1/0551 , A61N1/321 , A61N1/36053 , A61N1/3606 , A61N1/36071
摘要： A system comprising: at least one electrode adapted to be placed on a vagus nerve below a vagal innervation of the heart; an implantable controller comprising an induction coil, at least one circuit for generating a neural conduction blocking signal connected to the at least one electrode, a battery, and a central processing unit comprising program storage and memory; and an external programmer configured to: communicate at least one parameter for the neural conduction blocking signal to the implantable controller, wherein the parameter is selected for the neural conduction blocking signal to i) at least partially downregulate the vagus nerve, ii) allow at least partial recovery of the nerve activity following discontinuation of the neural conduction blocking signal, and iii) reduce pancreatic and biliary output via inhibition of pancreo-biliary output; and an external coil adapted to be worn by the patient, wherein the external coil is connected to the external programmer, and is adapted to inductively couple to the induction coil of the implantable controller.
摘要翻译： 一种系统，包括：适于放置在迷走神经支配下面的迷走神经上的至少一个电极; 包括感应线圈的可植入控制器，用于产生连接到所述至少一个电极的神经传导阻断信号的至少一个电路，电池和包括程序存储和存储器的中央处理单元; 以及外部编程器，其被配置为：将至少一个神经传导阻断信号的参数传送到所述可植入控制器，其中所述参数被选择用于所述神经传导阻断信号，i）至少部分地下调迷走神经，ii）至少允许 中断神经传导阻滞信号后部分恢复神经活动，以及iii）通过抑制胰胆管输出来减少胰腺和胆汁输出; 以及适于由患者佩戴的外部线圈，其中所述外部线圈连接到所述外部编程器，并且适于感应地耦合到所述可植入控制器的感应线圈。
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公开(公告)号：US20110034968A1
公开(公告)日：2011-02-10
申请号：US12908375
申请日：2010-10-20
IPC分类号： A61N1/00
CPC分类号： A61N1/36085 , A61N1/05 , A61N1/321 , A61N1/36007 , A61N1/36053 , A61N1/36071 , A61N1/36114 , A61N1/36178
摘要： A method for treating at least one of a plurality of disorders characterized at least in part by vagal activity includes positioning an electrode around a body organ innervated by the vagus. An electrical signal is applied to the electrode to modulate vagal activity. The electrical signal is applied at a frequency selected for the signal to create a neural conduction block to the vagus with the neural conduction block selected to at least partially block nerve impulses on the vagus. The application of the electrical signal is discontinued. The application of the signal and the discontinuing of the signal are repeated with durations of the discontinuing and the application selected to treat the disorder.
摘要翻译： 用于治疗至少部分由迷走神经活动表征的多种疾病中的至少一种的方法包括将电极定位在由迷走神经支配的身体器官周围。 将电信号施加到电极以调节迷走神经活性。 电信号被施加在为信号选择的频率上，以向迷走神经产生神经传导阻滞，其中神经传导阻滞被选择以至少部分阻断迷走神经上的脉冲。 电信号的应用被停止。 重复信号的应用和信号的中断，并且选择停止和应用的持续时间来治疗疾病。
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7.发明授权公开(公告)号：US07729771B2
公开(公告)日：2010-06-01
申请号：US11891770
申请日：2007-08-13
IPC分类号： A61N1/05
CPC分类号： A61N1/36007 , A61N1/05 , A61N1/0551 , A61N1/321 , A61N1/36053 , A61N1/3606 , A61N1/36071
摘要： At least one of a plurality of gastrointestinal disorders is treated by stimulating an enteric nervous system of a patient to enhance a functional tone of the enteric nervous system. A treatment includes electrically stimulating a vagus nerve of the patient at a stimulation site proximal to at least one site of vagal innervation of a gastrointestinal organ. The electrical stimulation includes applying a stimulation signal at the stimulation site. An optional proximal electrical blocking signal is applied to the vagus nerve at a proximal blocking site proximal to the stimulation site. The proximal blocking signal is selected to at least partially block nerve impulses at the proximal blocking site.
摘要翻译： 通过刺激患者的肠神经系统来治疗多种胃肠道疾病中的至少一种，以增强肠神经系统的功能性色调。 治疗包括在靠近胃肠器官的迷走神经支配的至少一个部位的刺激部位电刺激患者的迷走神经。 电刺激包括在刺激部位施加刺激信号。 在靠近刺激部位的近端阻塞位置，将可选的近端电阻塞信号施加到迷走神经。 选择近端阻塞信号以至少部分阻断近端阻塞部位处的神经冲动。
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公开(公告)号：US08538533B2
公开(公告)日：2013-09-17
申请号：US13276638
申请日：2011-10-19
IPC分类号： A61N1/36
CPC分类号： A61N1/36085 , A61N1/05 , A61N1/321 , A61N1/36007 , A61N1/36053 , A61N1/36071 , A61N1/36114 , A61N1/36178
摘要： Systems and methods for treating at least one of a plurality of disorders characterized at least in part by vagal activity. In embodiments, a method for treating obesity comprises positioning a first electrode on a vagus nerve of an obese patient at a location below a vagal innervation of the heart; treating the patient's obesity by applying an electrical treatment signal to the electrode with the electrical treatment signal having: a frequency selected for the signal to at least partially downregulate nerve impulses on the vagal nerve, wherein the signal has a frequency in excess of 200 Hz, and without simultaneously applying a neural impulse-inducing secondary electrical signal to the vagus nerve on a proximal side of the location whenever the electrical treatment signal is applied; and b) a plurality of on-times separated by a plurality of off-times, the signal applied during the on-times and not applied during the off-times, wherein the duration of the off-times is selected in response to a signal from a sensing electrode representing at least 50% of the activity of the vagal nerve as compared to baseline.
摘要翻译： 用于治疗至少部分地由迷走神经活性表征的多种疾病中的至少一种的系统和方法。 在实施方案中，治疗肥胖症的方法包括将第一电极定位在心脏的迷走神经支配下方的肥胖患者的迷走神经上; 通过向电极施加电治疗信号来治疗患者的肥胖，其中电治疗信号具有：为信号选择的频率至少部分地下调迷走神经上的神经冲动，其中信号具有超过200Hz的频率， 并且每当施加电治疗信号时，不同时在该位置的近端侧向迷走神经施加神经脉冲诱导次级电信号; 以及b）由多个关闭时间分离的多个接通时间，在接通时间期间施加的信号，并且在关闭时间期间不施加，其中响应于信号选择关闭时间的持续时间 来自感测电极，与基线相比，代表迷走神经的活性的至少50％。
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公开(公告)号：US20110282411A1
公开(公告)日：2011-11-17
申请号：US13188293
申请日：2011-07-21
IPC分类号： A61N1/36
CPC分类号： A61N1/36007 , A61N1/05 , A61N1/0551 , A61N1/321 , A61N1/36053 , A61N1/3606 , A61N1/36071
摘要： At least one of a plurality of gastrointestinal disorders is treated by stimulating an enteric nervous system of a patient to enhance a functional tone of the enteric nervous system. A treatment includes electrically stimulating a vagus nerve of the patient at a stimulation site proximal to at least one site of vagal innervation of a gastrointestinal organ. The electrical stimulation includes applying a stimulation signal at the stimulation site. An optional proximal electrical blocking signal is applied to the vagus nerve at a proximal blocking site proximal to the stimulation site. The proximal blocking signal is selected to at least partially block nerve impulses at the proximal blocking site.
摘要翻译： 通过刺激患者的肠神经系统来治疗多种胃肠道疾病中的至少一种，以增强肠神经系统的功能性色调。 治疗包括在靠近胃肠器官的迷走神经支配的至少一个部位的刺激部位电刺激患者的迷走神经。 电刺激包括在刺激部位施加刺激信号。 在靠近刺激部位的近端阻塞位置，将可选的近端电阻塞信号施加到迷走神经。 选择近端阻塞信号以至少部分阻断近端阻塞部位处的神经冲动。
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公开(公告)号：US07630769B2
公开(公告)日：2009-12-08
申请号：US11656122
申请日：2007-01-22
IPC分类号： A61N1/18
CPC分类号： A61N1/36053 , A61F5/0026 , A61N1/05 , A61N1/321 , A61N1/36007 , A61N1/36071 , A61N1/36082 , A61N1/37235
摘要： Methods and an apparatus are described for treating at least one of a plurality of disorders of a patient characterized at least in part by vagal activity innervating at least one of a plurality of organs of the patient. Embodiments include a method for treating a patient having a gastro-intestinal disorder having a inflammatory basis, including positioning an electrode on a vagus nerve below a vagal innervation of a heart of the patient, and treating the patient's gastro-intestinal disorder by applying an electrical signal to the electrode, wherein the signal has a frequency of at least 500 Hz and is selected to down-regulate neural activity on the vagus nerve, allow partial restoration of nerve activity upon discontinuation of the electrical signal, and wherein the signal is configured to reduce pancreatic output and biliary output. An electrical signal is applied to the electrode to modulate vagal activity by an amount selected to treat the disorder. The signal may be blocking or a stimulation signal.
摘要翻译： 描述了用于治疗患者的多种疾病中的至少一种的方法和装置，其特征在于至少部分地由支配患者的多个器官中的至少一个的迷走神经活动。 实施方案包括用于治疗患有炎症基础的胃肠道疾病的患者的方法，包括将电极定位在患者心脏的迷走神经支配以下的迷走神经上，并通过施加电气来治疗患者的胃肠道疾病 信号到所述电极，其中所述信号具有至少500Hz的频率并且被选择为下调迷走神经的神经活动，允许在停止电信号时部分恢复神经活动，并且其中所述信号被配置为 减少胰腺输出和胆汁输出。 将电信号施加到电极，以通过选择用于治疗病症的量来调节迷走神经活性。 信号可能是阻塞或刺激信号。
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