Biglycan and related therapeutics and methods of use
    10.
    发明授权
    Biglycan and related therapeutics and methods of use 有权
    Biglycan及相关疗法及使用方法

    公开(公告)号:US08658596B2

    公开(公告)日:2014-02-25

    申请号:US12881891

    申请日:2010-09-14

    IPC分类号: A61K38/00 C07K1/00 C07K14/00

    摘要: The invention provides compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan; disorders associated with an unstable cytoplasmic membrane, due, e.g., to an unstable dystrophin associated protein complex (DAPC); disorders associated with abnormal synapses or neuromuscular junctions, including those resulting from an abnormal MuSK activation or acetylcholine receptor (AChR) aggregation. Examples of diseases include muscular dystrophies, such as Duchenne's Muscular Dystrophy, Becker's Muscular Dystrophy, neuromuscular disorders and neurological disorders.

    摘要翻译: 本发明提供了用于治疗,预防和诊断与双糖链蛋白聚糖异常水平或活性相关的疾病或病症的组合物和方法; 与不稳定的细胞质膜相关的病症,例如由于不稳定的肌营养不良蛋白相关蛋白复合物(DAPC)引起; 与异常突触或神经肌肉接头相关的疾病,包括由异常的MuSK激活或乙酰胆碱受体(AChR)聚集而产生的疾病。 疾病的例子包括肌营养不良症,例如Duchenne's Muscular Dystrophy,Becker's Muscular Dystrophy,神经肌肉疾病和神经障碍。