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公开(公告)号：US20090192153A1
公开(公告)日：2009-07-30
申请号：US12067780
申请日：2006-09-21
申请人： Kazuki Hashimoto , Tomoaki Nakamura , Kei Nakamura , Ayumu Kurimoto , Yoshiaki Isobe , Haruhisa Ogita , Ian Millichip , Thomas Mcinally , Roger Bonnert
发明人： Kazuki Hashimoto , Tomoaki Nakamura , Kei Nakamura , Ayumu Kurimoto , Yoshiaki Isobe , Haruhisa Ogita , Ian Millichip , Thomas Mcinally , Roger Bonnert
IPC分类号： A61K31/5377 , C07D473/34 , A61K31/522 , A61P37/08
CPC分类号： C07D473/18
摘要： An adenine compound or its pharmaceutically acceptable salt as a medicament as shown following formula (1): wherein R1 is optionally substituted alkyl group, etc., X is oxygen atom, etc., A is 4 to 8 membered optionally substituted saturated or unsaturated heterocyclic group containing 1 to 2 hetero atoms selected from 1 to 3 nitrogen atoms, 0 to 1 oxygen atom and 0 to 1 sulfur atom, L1 and L2 are independently straight or branched chain alkylene, or a single bond, R2 is optionally substituted alkyl group, etc.
摘要翻译： 腺嘌呤化合物或其药学上可接受的盐作为如下式（1）所示的药物：其中R 1是任选取代的烷基等，X是氧原子等，A是4至8元任选取代的饱和或不饱和杂环 含有1至2个选自1至3个氮原子，0至1个氧原子和0至1个硫原子的杂原子的基团，L1和L2独立地为直链或支链亚烷基或单键，R2为任选取代的烷基， 等等
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公开(公告)号：US20090118263A1
公开(公告)日：2009-05-07
申请号：US12067649
申请日：2006-09-20
IPC分类号： A61K31/551 , C07D473/00 , A61K31/522 , C07D413/02 , A61K31/5386 , A61P37/08 , A61P35/00 , A61P37/02 , A61K31/5377 , A61K31/496 , C07D243/08
CPC分类号： C07D473/16 , C07D473/18 , C07D519/00
摘要： An adenine compound represented by the formula (1): (1) [wherein A1 and A2 each independently represents an (un)substituted aromatic carbocycle or (un)substituted aromatic heterocycle; L1, L2, and L3 each independently represents alkylene or a single bond, provided that any methylene or methine group in L2 or L3 may be bonded to the nitrogen atom adjacent to L2 and L3 to form a 4- to 7-membered saturated nitrogenous heterocycle; L4 represents alkylene or a single bond; R1 represents (un)substituted alkyl, (un)substituted aryl, etc.; R2 represents hydrogen or (un)substituted alkyl; R3 represents (un)substituted alkyl, etc.; and X represents oxygen, etc.] or a pharmaceutically acceptable salt of the compound. The compound and salt are useful as a medicine.
摘要翻译： 由式（1）表示的腺嘌呤化合物：（1）[其中，A1和A2各自独立地表示（un）取代的芳族碳环或（un）取代的芳族杂环; L1，L2和L3各自独立地表示亚烷基或单键，条件是L2或L3中的任何亚甲基或次甲基可以键合到与L2和L3相邻的氮原子上以形成4-至7-元饱和含氮杂环 ; L4表示亚烷基或单键; R1表示（un）取代的烷基，（un）取代的芳基等; R2代表氢或（未）取代的烷基; R3表示（un）取代的烷基等; X表示氧等]或化合物的药学上可接受的盐。 化合物和盐可用作药物。
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公开(公告)号：US20090105212A1
公开(公告)日：2009-04-23
申请号：US12067651
申请日：2006-09-22
IPC分类号： A61K31/522 , C07D473/34 , A61P31/18
CPC分类号： C07D473/18
摘要： A novel adenine compound represented by the formula (1): wherein A represents an (un)substituted aromatic carbocycle or (un)substituted aromatic heterocycle; L1, L2, and L3 each independently represents linear or branched alkylene, etc.; R1 represents (un)substituted alkyl, (un)substituted aryl, etc.; R2 represents hydrogen or (un) substituted alkyl; R3 represents (un)substituted alkyl, etc., provided that R3 may be bonded to L2 or L3 to form a nitrogenous saturated heterocycle; and X represents oxygen, etc.; or a pharmaceutically acceptable salt of the compound. The compound and salt are useful as a medicine.
摘要翻译： 由式（1）表示的新型腺嘌呤化合物：其中A表示（un）取代的芳族碳环或（un）取代的芳族杂环; L1，L2和L3各自独立地表示直链或支链亚烷基等; R1表示（un）取代的烷基，（un）取代的芳基等; R2代表氢或（未）取代的烷基; R3表示（un）取代的烷基等，条件是R3可以键合到L2或L3以形成含氮饱和杂环; X表示氧等。 或该化合物的药学上可接受的盐。 化合物和盐可用作药物。
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公开(公告)号：US20080269240A1
公开(公告)日：2008-10-30
申请号：US12067446
申请日：2006-09-21
申请人： Kazuki Hashimoto , Tomoaki Nakamura , Kei Nakamura , Shingo Tojo , Ayumu Kurimoto , Yoshiaki Isobe , Hiroki Wada , Roger Bonnert
发明人： Kazuki Hashimoto , Tomoaki Nakamura , Kei Nakamura , Shingo Tojo , Ayumu Kurimoto , Yoshiaki Isobe , Hiroki Wada , Roger Bonnert
IPC分类号： A61K31/522 , C07D473/18 , A61P31/12
CPC分类号： C07D473/18
摘要： An adenine compound useful as a medicine represented by the following formula (1): [wherein R1 is halogen atom, optionally substituted alkyl group, optionally substituted aryl group, etc.; X is oxygen atom, sulfur atom, a single bond, etc.; A1 is optionally substituted and optionally saturated 4 to 8 membered heterocyclic group containing 1 to 2 hetero atoms selected from 1 to 3 nitrogen atoms, 0 to 1 oxygen atom, and 0 to 1 sulfur atom; A2 is optionally substituted 6 to 10 cyclic aromatic hydrocarbon group or optionally substituted 5 to 10 membered heterocyclic aromatic group; L1 and L2 are independently, substituted straight or branched alkylene or a single bond, etc.; L3 is optionally substituted straight or branched alkylene, etc.; R2 is hydrogen atom, optionally substituted alkyl group.] or its pharmaceutically acceptable salt.
摘要翻译： 用作下式（1）表示的药物的腺嘌呤化合物：其中R 1是卤素原子，任选取代的烷基，任选取代的芳基等; X是氧原子，硫原子，单键等; 任选被取代的和任选饱和的含有1至2个选自1至3个氮原子，0至1个氧原子和0至1个硫原子的杂原子的4至8元杂环基; 任选取代的6至10个环状芳族烃基或任选取代的5至10元杂环芳基; L 1和L 2独立地为取代的直链或支链亚烷基或单键等; L 3是任选取代的直链或支链亚烷基等; R 2是氢原子，任选取代的烷基。]或其药学上可接受的盐。
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公开(公告)号：US20070225303A1
公开(公告)日：2007-09-27
申请号：US10594074
申请日：2005-03-25
IPC分类号： A61K31/522 , C07D473/34
CPC分类号： C07D473/16 , A61K31/522 , A61K31/5377 , C07D473/18 , C07D473/24 , C07D473/34
摘要： An 8-oxoadenine compound useful as an immuno-modulator having specific activity against Th1/Th2, specifically a prophylactic and therapeutic agent for a topical application for allergic diseases, viral diseases and cancers, which is represented by the following formula (1): wherein A is a group of a formula represented by the formula (2): wherein R2 is a substituted or unsubstituted alkyl group and so on, R3 is hydrogen atom or an alkyl group, R is a halogen atom and so on, n is 0˜2, X1 is oxygen atom, Z is straight or branched chain alkylene, and R1 is an alkyl group which is optionally substituted by hydroxy group, an alkoxy group, alkoxycarbonyl group and so on, or its pharmaceutically acceptable salt.
摘要翻译： 可用作对Th1 / Th2具有比活性的免疫调节剂的8-氧基腺嘌呤化合物，特别是用于过敏性疾病，病毒性疾病和癌症的局部应用的预防和治疗剂，其由下式（1）表示：其中 A是由式（2）表示的式的基团：其中R 2是取代或未取代的烷基等，R 3是氢原子或 烷基，R为卤素原子等，n为0〜2，X 1为氧原子，Z为直链或支链亚烷基，R 1为 任选被羟基，烷氧基，烷氧基羰基等取代的烷基或其药学上可接受的盐。
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公开(公告)号：US20140045837A1
公开(公告)日：2014-02-13
申请号：US14058064
申请日：2013-10-21
申请人： Ayumu Kurimoto , Kazuki Hashimoto , Yoshiaki Isobe , Stephen Brough , Ian Millichip , Hiroki Wada , Roger Bonnert , Thomas Mcinally
发明人： Ayumu Kurimoto , Kazuki Hashimoto , Yoshiaki Isobe , Stephen Brough , Ian Millichip , Hiroki Wada , Roger Bonnert , Thomas Mcinally
IPC分类号： C07D473/18
CPC分类号： C07D473/18 , A61K31/522 , A61K31/5377
摘要： The present invention provides an 8-oxoadenine compound having immunomodulating activities such as an interferon inducing activity and useful as an antiviral agent and antiallergic agent, which is represented by the following formula (1): [wherein the ring A represents a 6-10 membered aromatic carbocyclic ring and the like, R represents a halogen atom, an alkyl group and the like, n represents an integer of 0-2, Z1 represents alkylene, X2 represents oxygen atom, sulfur atom, SO2, NR5, CO, CONR5, NR5CO and the like, Y1, Y2 and Y3 represent independently a single bond or an alkylene group, X1 represents oxygen atom, sulfur atom, NR4 (R4 is hydrogen atom or an alkyl group) or a single bond, R2 represents a substituted or unsubstituted alkyl group, R1 represents hydrogen atom, hydroxy group, an alkoxy group, an alkoxycarbonyl group or a haloalkyl group] or its pharmaceutically acceptable salt.
摘要翻译： 本发明提供具有免疫调节活性的8-氧代腺嘌呤化合物，例如干扰素诱导活性，可用作抗病毒剂和抗变应性剂，其由下式（1）表示：[其中环A表示6-10元 芳香族碳环等，R表示卤素原子，烷基等，n表示0-2的整数，Z1表示亚烷基，X2表示氧原子，硫原子，SO2，NR5，CO，CONR5，NR5CO 等等，Y1，Y2和Y3独立地表示单键或亚烷基，X1表示氧原子，硫原子，NR4（R4是氢原子或烷基）或单键，R2表示取代或未取代的烷基 基团，R 1表示氢原子，羟基，烷氧基，烷氧基羰基或卤代烷基]或其药学上可接受的盐。
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公开(公告)号：US08575180B2
公开(公告)日：2013-11-05
申请号：US13187260
申请日：2011-07-20
申请人： Ayumu Kurimoto , Kazuki Hashimoto , Yoshiaki Isobe , Stephen Brough , Ian Millichip , Hiroki Wada , Roger Bonnert , Thomas Mcinally
发明人： Ayumu Kurimoto , Kazuki Hashimoto , Yoshiaki Isobe , Stephen Brough , Ian Millichip , Hiroki Wada , Roger Bonnert , Thomas Mcinally
IPC分类号： A61K31/52 , C07D473/00
CPC分类号： C07D473/18 , A61K31/522 , A61K31/5377
摘要： The present invention provides an 8-oxoadenine compound having immunemodulating activities such as an interferon inducing activity and useful as an antiviral agent and antiallergic agent, which is represented by the following formula (1): [wherein the ring A represents a 6-10 membered aromatic carbocyclic ring and the like, R represents a halogen atom, an alkyl group and the like, n represents an integer of 0-2, Z1 represents alkylene, X2 represents oxygen atom, sulfur atom, SO2, NR5, CO, CONR5, NR5CO and the like, Y1, Y2 and Y3 represent independently a single bond or an alkylene group, X1 represents oxygen atom, sulfur atom, NR4 (R4 is hydrogen atom or an alkyl group) or a single bond, R2 represents a substituted or unsubstituted alkyl group, R1 represents hydrogen atom, hydroxy group, an alkoxy group, an alkoxycarbonyl group or a haloalkyl group] or its pharmaceutically acceptable salt.
摘要翻译： 本发明提供具有免疫调节活性的8-氧代腺嘌呤化合物，例如干扰素诱导活性，可用作抗病毒剂和抗变应性剂，其由下式（1）表示：[其中环A表示6-10元 芳香族碳环等，R表示卤素原子，烷基等，n表示0-2的整数，Z1表示亚烷基，X2表示氧原子，硫原子，SO2，NR5，CO，CONR5，NR5CO 等等，Y1，Y2和Y3独立地表示单键或亚烷基，X1表示氧原子，硫原子，NR4（R4是氢原子或烷基）或单键，R2表示取代或未取代的烷基 基团，R 1表示氢原子，羟基，烷氧基，烷氧基羰基或卤代烷基]或其药学上可接受的盐。
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公开(公告)号：US20110306610A1
公开(公告)日：2011-12-15
申请号：US13187260
申请日：2011-07-20
申请人： Ayumu KURIMOTO , Kazuki Hashimoto , Yoshiaki Isobe , Stephen Brough , Ian Millichip , Hiroki Wada , Roger Bonnert , Thomas Mcinally
发明人： Ayumu KURIMOTO , Kazuki Hashimoto , Yoshiaki Isobe , Stephen Brough , Ian Millichip , Hiroki Wada , Roger Bonnert , Thomas Mcinally
IPC分类号： A61K31/522 , C07D413/14 , A61P37/08 , A61P37/00 , A61P31/12 , A61P35/00 , C07D473/18 , A61K31/5377
CPC分类号： C07D473/18 , A61K31/522 , A61K31/5377
摘要： The present invention provides an 8-oxoadenine compound having immunemodulating activities such as an interferon inducing activity and useful as an antiviral agent and antiallergic agent, which is represented by the following formula (1): [wherein the ring A represents a 6-10 membered aromatic carbocyclic ring and the like, R represents a halogen atom, an alkyl group and the like, n represents an integer of 0-2, Z1 represents alkylene, X2 represents oxygen atom, sulfur atom, SO2, NR5, CO, CONR5, NR5CO and the like, Y1, Y2 and Y3 represent independently a single bond or an alkylene group, X1 represents oxygen atom, sulfur atom, NR4 (R4 is hydrogen atom or an alkyl group) or a single bond, R2 represents a substituted or unsubstituted alkyl group, R1 represents hydrogen atom, hydroxy group, an alkoxy group, an alkoxycarbonyl group or a haloalkyl group] or its pharmaceutically acceptable salt.
摘要翻译： 本发明提供具有免疫调节活性的8-氧代腺嘌呤化合物，例如干扰素诱导活性，可用作抗病毒剂和抗变应性剂，其由下式（1）表示：[其中环A表示6-10元 芳香族碳环等，R表示卤素原子，烷基等，n表示0-2的整数，Z1表示亚烷基，X2表示氧原子，硫原子，SO2，NR5，CO，CONR5，NR5CO 等等，Y1，Y2和Y3独立地表示单键或亚烷基，X1表示氧原子，硫原子，NR4（R4是氢原子或烷基）或单键，R2表示取代或未取代的烷基 基团，R 1表示氢原子，羟基，烷氧基，烷氧基羰基或卤代烷基]或其药学上可接受的盐。
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公开(公告)号：US08969362B2
公开(公告)日：2015-03-03
申请号：US14058064
申请日：2013-10-21
申请人： Ayumu Kurimoto , Kazuki Hashimoto , Yoshiaki Isobe , Stephen Brough , Ian Millichip , Hiroki Wada , Roger Bonnert , Thomas Mcinally
发明人： Ayumu Kurimoto , Kazuki Hashimoto , Yoshiaki Isobe , Stephen Brough , Ian Millichip , Hiroki Wada , Roger Bonnert , Thomas Mcinally
IPC分类号： A61K31/522 , C07D473/18 , A61K31/5377
CPC分类号： C07D473/18 , A61K31/522 , A61K31/5377
摘要： The present invention provides an 8-oxoadenine compound having immunomodulating activities such as an interferon inducing activity and useful as an antiviral agent and antiallergic agent, which is represented by the following formula (1): [wherein the ring A represents a 6-10 membered aromatic carbocyclic ring and the like, R represents a halogen atom, an alkyl group and the like, n represents an integer of 0-2, Z1 represents alkylene, X2 represents oxygen atom, sulfur atom, SO2, NR5, CO, CONR5, NR5CO and the like, Y1, Y2 and Y3 represent independently a single bond or an alkylene group, X1 represents oxygen atom, sulfur atom, NR4 (R4 is hydrogen atom or an alkyl group) or a single bond, R2 represents a substituted or unsubstituted alkyl group, R1 represents hydrogen atom, hydroxy group, an alkoxy group, an alkoxycarbonyl group or a haloalkyl group] or its pharmaceutically acceptable salt.
摘要翻译： 本发明提供具有免疫调节活性的8-氧代腺嘌呤化合物，例如干扰素诱导活性，可用作抗病毒剂和抗变应性剂，其由下式（1）表示：[其中环A表示6-10元 芳香族碳环等，R表示卤素原子，烷基等，n表示0-2的整数，Z1表示亚烷基，X2表示氧原子，硫原子，SO2，NR5，CO，CONR5，NR5CO 等等，Y1，Y2和Y3独立地表示单键或亚烷基，X1表示氧原子，硫原子，NR4（R4是氢原子或烷基）或单键，R2表示取代或未取代的烷基 基团，R 1表示氢原子，羟基，烷氧基，烷氧基羰基或卤代烷基]或其药学上可接受的盐。
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公开(公告)号：US20070190071A1
公开(公告)日：2007-08-16
申请号：US10593691
申请日：2005-03-24
申请人： Ayumu Kurimoto , Kazuki Hashimoto , Yoshiaki Isobe , Stephen Brough , Ian Millichip , Hiroki Wada , Roger Bonnert , Thomas Mcinally
发明人： Ayumu Kurimoto , Kazuki Hashimoto , Yoshiaki Isobe , Stephen Brough , Ian Millichip , Hiroki Wada , Roger Bonnert , Thomas Mcinally
IPC分类号： A61K31/52 , A61K31/522 , C07D473/10
CPC分类号： C07D473/18 , A61K31/522 , A61K31/5377
摘要： The present invention provides an 8-oxoadenine compound having immunemodulating activities such as an interferon inducing activity and useful as an antiviral agent and antiallergic agent, which is represented by the following formula (1): [wherein the ring A represents a 6-10 membered aromatic carbocyclic ring and the like, R represents a halogen atom, an alkyl group and the like, n represents an integer of 0-2, Z1 represents alkylene, X2 represents oxygen atom, sulfur atom, SO2, NR5, CO, CONR5, NR5CO and the like, Y1, Y2 and Y3 represent independently a single bond or an alkylene group, X1 represents oxygen atom, sulfur atom, NR4 (R4 is hydrogen atom or an alkyl group) or a single bond, R2 represents a substituted or unsubstituted alkyl group, R1 represents hydrogen atom, hydroxy group, an alkoxy group, an alkoxycarbonyl group or a haloalkyl group]or its pharmaceutically acceptable salt.
摘要翻译： 本发明提供具有免疫调节活性的8-氧代腺嘌呤化合物，例如干扰素诱导活性，可用作抗病毒剂和抗变应性剂，其由下式（1）表示：[其中环A表示6-10元 芳香族碳环等，R表示卤素原子，烷基等，n表示0〜2的整数，Z 1表示亚烷基，X 2， 表示氧原子，硫原子，SO 2，NR 5，CO，CONR 5，NR 5 CO和 Y 1，Y 2和Y 3独立地表示单键或亚烷基，X 1，O 2， >表示氧原子，硫原子，NR 4（R 4）是氢原子或烷基或单键，R 2表示 取代或未取代的烷基，R 1表示氢原子，羟基，烷氧基，烷氧基羰基或 芳烷基]或其药学上可接受的盐。
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