公开(公告)号：US20060205745A1

公开(公告)日：2006-09-14

申请号：US10554511

申请日：2004-05-07

申请人： Kazutoshi Kuroda ,  Noboru Aoki ,  Toshiro Ochiai ,  Akihiro Uchida ,  Yasuhiro Ishikawa ,  Makoto Kigoshi ,  Eiji Hayakawa

发明人： Kazutoshi Kuroda ,  Noboru Aoki ,  Toshiro Ochiai ,  Akihiro Uchida ,  Yasuhiro Ishikawa ,  Makoto Kigoshi ,  Eiji Hayakawa

IPC分类号： A61K31/522 ,  C07D473/02

CPC分类号： C07D473/06

摘要： Microcrystals of (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione having an average particle size of less than 50 μm; microcrystals of (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione having an average particle size of less than 50 μm and a crystallinity of 20% or more or the like, which possess excellent solubility, stability, bioavailability, dispersing property in a pharmaceutical formulation; and the like are provided. A solid pharmaceutical formulation which is characterized by comprising the same is also provided.

公开(公告)号：US07541363B2

公开(公告)日：2009-06-02

申请号：US10554511

申请日：2004-05-07

申请人： Kazutoshi Kuroda ,  Noboru Aoki ,  Toshiro Ochiai ,  Akihiro Uchida ,  Yasuhiro Ishikawa ,  Makoto Kigoshi ,  Eiji Hayakawa ,  Kazuki Asanome

发明人： Kazutoshi Kuroda ,  Noboru Aoki ,  Toshiro Ochiai ,  Akihiro Uchida ,  Yasuhiro Ishikawa ,  Makoto Kigoshi ,  Eiji Hayakawa ,  Kazuki Asanome

IPC分类号： C07D473/06 ,  A61K31/522

CPC分类号： C07D473/06

摘要： Microcrystals of (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione having an average particle size of less than 50 μm; microcrystals of (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione having an average particle size of less than 50 μm and a crystallinity of 20% or more or the like, which possess excellent solubility, stability, bioavailability, dispersing property in a pharmaceutical formulation; and the like are provided. A solid pharmaceutical formulation which is characterized by comprising the same is also provided.

摘要翻译： 平均粒径小于50埃的（E）-8-（3,4-二甲氧基苯乙烯基）-1,3-二乙基-7-甲基-3,7-二氢-1H-嘌呤-2,6-二酮的微晶 妈妈 （E）-8-（3,4-二甲氧基苯乙烯基）-1,3-二乙基-7-甲基-3,7-二氢-1H-嘌呤-2,6-二酮的微晶，平均粒径小于50 具有优异的溶解性，稳定性，生物利用度，药物配方中的分散性的20％以上的结晶度等。 等等。 还提供了其特征在于包含其的固体药物制剂。

公开(公告)号：US20060134192A1

公开(公告)日：2006-06-22

申请号：US10528451

申请日：2004-09-29

申请人： Akihiro Uchida ,  Yasuhiro Ishikawa ,  Yasuhiko Ueno ,  Kiichiro Kaji ,  Masaharu Aimoto ,  Naoki Kaneko

发明人： Akihiro Uchida ,  Yasuhiro Ishikawa ,  Yasuhiko Ueno ,  Kiichiro Kaji ,  Masaharu Aimoto ,  Naoki Kaneko

IPC分类号： A61K31/522 ,  A61K9/20

CPC分类号： A61K9/2018 ,  A61K9/2813 ,  A61K9/2866 ,  A61K31/522 ,  C07D473/06

摘要： (wherein Y1 and Y2 may be the same or different and each represents a hydrogen atom, halogen or lower alkyl; and Z and A may be the same or different and each represents substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl) The present invention provides, for example, a method for stabilization of a diarylvinylene compound such as a compound represented by the above formula (I) or the like, or a pharmaceutically acceptable salt thereof in a solid formulation containing the diarylvinylene compound or the pharmaceutically acceptable salt thereof, which comprises allowing an inorganic substance and/or a colorant to exist in the solid formulation, and the like.

摘要翻译： （其中Y 1和Y 2可以相同或不同，各自表示氢原子，卤素或低级烷基; Z和A可以相同或不同， 各自表示取代或未取代的芳基或取代或未取代的杂芳基）本发明提供例如稳定二芳基亚乙烯基化合物如上式（I）等表示的化合物或其药学上可接受的盐 其包含含有二芳基亚乙烯基化合物或其药学上可接受的盐的固体制剂，其包括使无机物质和/或着色剂存在于固体制剂中等。

公开(公告)号：US20060029663A1

公开(公告)日：2006-02-09

申请号：US10515204

申请日：2004-07-16

申请人： Akihiro Uchida ,  Yasuhiro Ishikawa ,  Yasuhiko Ueno ,  Kiichiro Kaji ,  Tsuneaki Tottori

发明人： Akihiro Uchida ,  Yasuhiro Ishikawa ,  Yasuhiko Ueno ,  Kiichiro Kaji ,  Tsuneaki Tottori

IPC分类号： A61K31/522 ,  A61K9/20

CPC分类号： A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2866 ,  A61K31/522 ,  C07D473/04

摘要： (wherein R1, R2 and R3 may be the same or different and each represents a hydrogen atom, lower alkyl, lower alkenyl or lower alkynyl; and R4 represents cycloalkyl, —(CH2)n—R5 or the above formula (II)) The present invention provides a solid formulation comprising a xanthine derivative represented by the above formula (I) or a pharmaceutically acceptable salt thereof, and microcrystalline cellulose, which possesses excellent pharmaceutical properties, for example, in hardness, disintegration property, dissolution property, stability or the like.

摘要翻译： （其中R 1，R 2和R 3）可以相同或不同，并且各自表示氢原子，低级烷基，低级烯基或 低级炔基; R 4表示环烷基， - （CH 2）n - R 5 - 或上式 （II））本发明提供包含由上述式（I）表示的黄嘌呤衍生物或其药学上可接受的盐和微晶纤维素的固体制剂，其具有优异的药物性质，例如硬度，崩解性，溶解性 财产，稳定性等。

公开(公告)号：US08318201B2

公开(公告)日：2012-11-27

申请号：US10528451

申请日：2004-09-29

申请人： Akihiro Uchida ,  Yasuhiro Ishikawa ,  Yasuhiko Ueno ,  Kiichiro Kaji ,  Masaharu Aimoto ,  Naoki Kaneko

发明人： Akihiro Uchida ,  Yasuhiro Ishikawa ,  Yasuhiko Ueno ,  Kiichiro Kaji ,  Masaharu Aimoto ,  Naoki Kaneko

IPC分类号： A61K31/522 ,  A61K9/20

CPC分类号： A61K9/2018 ,  A61K9/2813 ,  A61K9/2866 ,  A61K31/522 ,  C07D473/06

摘要： (wherein Y1 and Y2 may be the same or different and each represents a hydrogen atom, halogen or lower alkyl; and Z and A may be the same or different and each represents substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl) The present invention provides, for example, a method for stabilization of a diarylvinylene compound such as a compound represented by the above formula (I) or the like, or a pharmaceutically acceptable salt thereof in a solid formulation containing the diarylvinylene compound or the pharmaceutically acceptable salt thereof, which comprises allowing an inorganic substance and/or a colorant to exist in the solid formulation, and the like.

摘要翻译： （其中Y1和Y2可以相同或不同，并且各自表示氢原子，卤素或低级烷基; Z和A可以相同或不同，各自表示取代或未取代的芳基或取代或未取代的杂芳基）本发明 提供了例如在含有二芳基亚乙烯基化合物或其药学上可接受的盐的固体制剂中稳定二芳基亚乙烯基化合物，例如由上式（I）表示的化合物或其药学上可接受的盐的方法， 其包括使无机物质和/或着色剂存在于固体制剂中等。

公开(公告)号：US20070064141A1

公开(公告)日：2007-03-22

申请号：US11599516

申请日：2006-11-15

申请人： Atsushi Misawa ,  Michitaka Nakazawa ,  Akihiro Uchida

发明人： Atsushi Misawa ,  Michitaka Nakazawa ,  Akihiro Uchida

IPC分类号： H04N5/222

CPC分类号： H04N5/2258 ,  H04N5/2253 ,  H04N5/23212 ,  H04N5/23245 ,  H04N5/23293 ,  H04N5/23296 ,  H04N5/272

摘要： A digital camera comprises two photographing systems which are independent of and substantially identical to each other, and each of which includes a photographing optical system and an image pickup device. The photographing optical system is configured to include a photographing lens, a focusing lens and an aperture stop. The focusing lens of one of the photographing systems is driven stepwise from a first predetermined position at which it is to be located when a focusing position lies at an infinite distance, toward a second predetermined position at which it is to be located when the focusing position lies at the closest distance, while the focusing lens of the other photographing system is driven stepwise from the second predetermined position toward the first predetermined position every step width. The contrasts of images formed by the respective photographing systems are evaluated while the two focusing lenses are being moved, and a position corresponding to the maximum value of the contrasts is determined as the focusing position.

公开(公告)号：US20050036342A1

公开(公告)日：2005-02-17

申请号：US10505795

申请日：2003-02-17

申请人： Akihiro Uchida

发明人： Akihiro Uchida

IPC分类号： H02M3/156 ,  H02M7/12 ,  H02H7/125

CPC分类号： H02M3/1563 ,  H02M7/125

摘要： A switching power source which enables a continuous operation of an apparatus even under an overvoltage test such as a ring wave test. In a case where the sensed voltage (Vb) of the secondary winding (5b) through a diode (D6), the Zener diode (ZD3), and a resistor (R21) to the non-inverting input terminal (+) of a comparator (31), and a high-level signal is inputted to a flip-flop (35) from the comparator (31). As a result, a high-level signal outputted from the Q output terminal is held and outputted to a flip-flop (15) as a reset signal via an OR circuit (37), so that a drive signal kept outputted from the Q output terminal of the flip-flop (15) switches to a low-level one to continue the off-control of the switching element (Q1).

摘要翻译： 一种开关电源，即使在诸如环形波测试的过压测试下也能够连续地操作设备。 在通过二极管（D6）的次级绕组（5b）的感测电压（Vb），齐纳二极管（ZD3）和比较器的非反相输入端子（+）的电阻器（R21）的情况下， （31），并且高电平信号从比较器（31）输入到触发器（35）。 结果，从Q输出端子输出的高电平信号通过OR电路（37）被保持并输出到作为复位信号的触发器（15），使得从Q输出端保持输出的驱动信号 触发器（15）的端子切换到低电平，以继续开关元件（Q1）的断开控制。

公开(公告)号：US06272024B1

公开(公告)日：2001-08-07

申请号：US09734145

申请日：2000-12-11

申请人： Akihiro Uchida

发明人： Akihiro Uchida

IPC分类号： H02M3335

摘要： A d.c.-to-d.c. converter of the kind having a step-up or step-down transformer with a primary to be connected to a d.c. power supply via an electronic switch, and a secondary to be connected to a load via a smoothing and rectifying circuit. The voltage being applied to the load is detected and fed back to a switch control circuit whereby the switch is controlled to keep constant the converter output voltage. Connected in parallel with the transformer primary, a surge suppressor circuit has a serial connection of a surge-absorbing capacitor and a rectifying diode and a resistor for absorbing a surge developing across the transformer primary winding each time the switch is turned off. In order to attenuate the high-frequency ringing of the voltage across the switch due to the leakage inductance and stray capacitance of the transformer primary and to the stray capacitance of the switch, the reverse recovery time of the diode of the surge suppressor circuit is made longer than half the cycle of the ringing voltage and shorter than the expected minimum non-conducting period of the switch.

公开(公告)号：US08111315B2

公开(公告)日：2012-02-07

申请号：US12253011

申请日：2008-10-16

申请人： Akihiro Uchida

发明人： Akihiro Uchida

IPC分类号： H04N5/335

CPC分类号： G06K9/00664 ,  H04N5/23219 ,  H04N5/23222 ,  H04N5/23293

摘要： An imaging device including an image pickup device which converts an optical image of a photographic subject received through an imaging lens into an image signal; a displaying device which displays a through-the-lens image based on the image signal; a person detecting device which detects one or more persons from the image signal; a distance calculating device which calculates a distance between a plurality of the detected persons; and a composition assisting device which displays on the displaying device information as to whether the distance between the detected persons is proper or not based on the calculated distance between the detected persons. Thereby, it is possible to obtain an image with a proper composition in a case when there are a plurality of persons being the photographic subjects.

摘要翻译： 一种成像装置，包括将通过成像透镜接收的摄影对象的光学图像转换为图像信号的图像拾取装置; 显示装置，其基于图像信号显示透镜图像; 人物检测装置，其从图像信号中检测一个或多个人; 距离计算装置，其计算多个检测到的人之间的距离; 以及构图辅助装置，其根据所计算的被检测人的距离，在显示装置上显示关于被检测人物之间的距离是否适当的信息。 因此，当存在多个人是摄影对象的情况下，可以获得具有适当构图的图像。

公开(公告)号：US20070103577A1

公开(公告)日：2007-05-10

申请号：US11599439

申请日：2006-11-15

申请人： Atsushi Misawa ,  Michitaka Nakazawa ,  Akihiro Uchida

发明人： Atsushi Misawa ,  Michitaka Nakazawa ,  Akihiro Uchida

IPC分类号： H04N5/222

CPC分类号： H04N5/2258 ,  H04N5/2253 ,  H04N5/23212 ,  H04N5/23245 ,  H04N5/23293 ,  H04N5/23296 ,  H04N5/272

摘要： A digital camera comprises two photographing systems which are independent of and substantially identical to each other, and each of which includes a photographing optical system and an image pickup device. The photographing optical system is configured to include a photographing lens, a focusing lens and an aperture stop. The focusing lens of one of the photographing systems is driven stepwise from a first predetermined position at which it is to be located when a focusing position lies at an infinite distance, toward a second predetermined position at which it is to be located when the focusing position lies at the closest distance, while the focusing lens of the other photographing system is driven stepwise from the second predetermined position toward the first predetermined position every step width. The contrasts of images formed by the respective photographing systems are evaluated while the two focusing lenses are being moved, and a position corresponding to the maximum value of the contrasts is determined as the focusing position.

摘要翻译： 数码相机包括彼此独立且基本相同的两个拍摄系统，并且每个照相系统包括拍摄光学系统和图像拾取装置。 拍摄光学系统被配置为包括拍摄镜头，聚焦透镜和孔径光阑。 当聚焦位置处于无限距离时，其中一个拍摄系统的聚焦透镜将从其位于待定位的第一预定位置逐步地朝着待聚焦位置处的第二预定位置被驱动 位于最接近的距离处，而另一拍摄系统的聚焦透镜从步骤宽度的第二预定位置朝着第一预定位置逐步驱动。 在移动两个聚焦透镜的同时评估由相应的拍摄系统形成的图像的对比度，并且将与对比度的最大值相对应的位置确定为聚焦位置。