公开(公告)号：US20090175930A1

公开(公告)日：2009-07-09

申请号：US12087674

申请日：2007-01-10

申请人： Nobuhiro Yagi ,  Masahiro Yamauchi ,  Noboru Aoki ,  Yasuhiro Tamaki ,  Hidenori Takahashi ,  Aya Iriyama ,  Ryozo Nagai ,  Ichiro Manabe

发明人： Nobuhiro Yagi ,  Masahiro Yamauchi ,  Noboru Aoki ,  Yasuhiro Tamaki ,  Hidenori Takahashi ,  Aya Iriyama ,  Ryozo Nagai ,  Ichiro Manabe

IPC分类号： A61K9/127 ,  A61K31/7052 ,  A61P27/02

CPC分类号： A61K9/1272 ,  A61K9/0048 ,  A61K9/127 ,  A61K31/7105 ,  A61K48/0033 ,  A61K48/0041 ,  C12N15/111 ,  C12N2310/14 ,  C12N2320/32

摘要： There is provided a composition comprising an RNA-encapsulated liposome, the RNA comprising a sequence being of 15 to 30 contiguous nucleotides of mRNA of a target gene associated with a disease in an eyeball, and a sequence complementary to the sequence, wherein the liposome is capable of reaching an eyeball, and the like. The liposome in which an RNA is encapsulated is, for example, a liposome composing a complex particle comprising a lead particle and the RNA as constituent components, the lead particle comprising a cationic lipid, and a bilayer lipid membrane for coating the complex particle. The bilayer lipid membrane is a bilayer lipid membrane comprising a neutral lipid, and a lipid derivative, a fatty acid derivative or an aliphatic hydrocarbon derivative of a water-soluble substance as constituent components.

摘要翻译： 提供了包含RNA包封的脂质体的组合物，所述RNA包含与眼球中的疾病相关的靶基因的mRNA的15-30个连续核苷酸的序列和与该序列互补的序列，其中所述脂质体是 能够达到眼球等。 其中包封RNA的脂质体是例如构成包含铅颗粒和RNA作为组成成分的复合颗粒的脂质体，包含阳离子脂质的铅颗粒和用于涂覆复合颗粒的双层脂质膜。 双层脂质膜是包含中性脂质和作为组成成分的水溶性物质的脂质衍生物，脂肪酸衍生物或脂肪族烃衍生物的双层脂质膜。

公开(公告)号：US5073741A

公开(公告)日：1991-12-17

申请号：US635730

申请日：1990-12-28

申请人： Takahiro Suzuki ,  Noboru Aoki

发明人： Takahiro Suzuki ,  Noboru Aoki

IPC分类号： H01T13/52 ,  H01T13/32

CPC分类号： H01T13/32

摘要： An igniter plug has a tubular metallic shell and an annular ground electrode each connected in series by an interfitting, and fixed by welding. The igniter plug further has a tubular insulator placed within both the metallic shell and the ground electrode, while a center electrode is placed within the insulator to be surrounded by the ground electrode. A plurality of lock arms are provided with a front end of the metallic shell, and each top end of lock arms has a pawl which is brought into an engagement with an inner wall of a groove which is provided with an inner surface of the ground electrode when the metallic shell and the ground electrode are connected, and at the same time, the insulator is brought into an engagement with an inner side of each lock arm to deter the lock arms from being flexed inwardly when the insulator is placed.

摘要翻译： 点火塞具有管状金属壳和环形接地电极，每个通过相互连接串联连接，并通过焊接固定。 点火器插头还具有放置在金属壳体和接地电极内的管状绝缘体，而中心电极放置在绝缘体内以被接地电极包围。 多个锁定臂设置有金属壳的前端，并且锁定臂的每个顶端具有棘爪，该棘爪与设置有接地电极的内表面的槽的内壁接合 当金属壳和接地电极连接时，同时绝缘体与每个锁定臂的内侧接合以阻止锁定臂在放置绝缘体时向内弯曲。

公开(公告)号：US4873466A

公开(公告)日：1989-10-10

申请号：US93975

申请日：1987-09-08

申请人： Shuzo Matsumura ,  Takanori Mizuno ,  Noboru Aoki ,  Takahire Suzuki

发明人： Shuzo Matsumura ,  Takanori Mizuno ,  Noboru Aoki ,  Takahire Suzuki

IPC分类号： H01T13/32 ,  H01T13/52

CPC分类号： H01T13/52 ,  H01T13/32

摘要： An igniter plug comprising: a metallic shell having a diameter-reduced seat at one open end, the seat being tapered to progressively decrease its diameter as approaching at outside of the open end; a tubular insulator concentrically placed at an inner side of the metallic shell, and having a tapered end face to be in registration with the seat; a frusto-cone shaped insert ring made of oxidation and heat resistant material, a peripheral end and one entire surface of which are mounted on a surface of the seat by means of an electrical resistant welding, the insert ring permitting the tapered end face of the insulator to engage with an upper surface of the insert ring; a center electrode concentrically disposed in the insulator, one end of the electrode being terminated short of the tapered end face to allow a creeping discharge to occur along an inner surface of the insulator when a high voltage is applied across the electrode and the insert ring.

摘要翻译： 一种点火器塞，包括：一个金属壳，在一个开口端具有直径减小的座，所述座是锥形的，以逐渐减小其在所述开口端外部接近的直径; 同心地放置在所述金属外壳的内侧的管状绝缘体，并且具有与所述座体对准的锥形端面; 由氧化和耐热材料制成的截头锥形插入环，其外端和整个表面通过电阻焊接安装在座的表面上，插入环允许锥形端面的锥形端面 绝缘体与插入环的上表面接合; 中心电极同心地设置在绝缘体中，电极的一端端接在锥形端面的端部，当跨过电极和插入环施加高电压时，允许沿着绝缘体的内表面发生沿面放电。

公开(公告)号：US07541363B2

公开(公告)日：2009-06-02

申请号：US10554511

申请日：2004-05-07

申请人： Kazutoshi Kuroda ,  Noboru Aoki ,  Toshiro Ochiai ,  Akihiro Uchida ,  Yasuhiro Ishikawa ,  Makoto Kigoshi ,  Eiji Hayakawa ,  Kazuki Asanome

发明人： Kazutoshi Kuroda ,  Noboru Aoki ,  Toshiro Ochiai ,  Akihiro Uchida ,  Yasuhiro Ishikawa ,  Makoto Kigoshi ,  Eiji Hayakawa ,  Kazuki Asanome

IPC分类号： C07D473/06 ,  A61K31/522

CPC分类号： C07D473/06

摘要： Microcrystals of (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione having an average particle size of less than 50 μm; microcrystals of (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione having an average particle size of less than 50 μm and a crystallinity of 20% or more or the like, which possess excellent solubility, stability, bioavailability, dispersing property in a pharmaceutical formulation; and the like are provided. A solid pharmaceutical formulation which is characterized by comprising the same is also provided.

摘要翻译： 平均粒径小于50埃的（E）-8-（3,4-二甲氧基苯乙烯基）-1,3-二乙基-7-甲基-3,7-二氢-1H-嘌呤-2,6-二酮的微晶 妈妈 （E）-8-（3,4-二甲氧基苯乙烯基）-1,3-二乙基-7-甲基-3,7-二氢-1H-嘌呤-2,6-二酮的微晶，平均粒径小于50 具有优异的溶解性，稳定性，生物利用度，药物配方中的分散性的20％以上的结晶度等。 等等。 还提供了其特征在于包含其的固体药物制剂。

公开(公告)号：US20100168140A1

公开(公告)日：2010-07-01

申请号：US12086550

申请日：2006-12-14

申请人： Makoto Kigoshi ,  Hideki Kato ,  Noboru Aoki

发明人： Makoto Kigoshi ,  Hideki Kato ,  Noboru Aoki

IPC分类号： A61K31/522

CPC分类号： A61K9/1617 ,  A61K9/0095 ,  A61K9/1611 ,  A61K9/1635 ,  A61K9/1652 ,  A61K9/2054 ,  A61K9/4858 ,  A61K31/52 ,  A61K31/522

摘要： An object of the present invention is to provide an easily absorbable oral preparation containing a xanthine derivative or a pharmaceutically acceptable salt thereof and a fatty acid or a fatty acid derivative for the purpose of providing an easily absorbable oral preparation containing the xanthine derivative of which absorbability has been enhanced by dissolving the xanthine derivative that shows adenosine A1 receptor antagonistic activity and has diuretic activity, kidney-protecting activity, bronchodilating activity, cerebral function-improving activity, anti-dementia activity or the like in a solvent.

摘要翻译： 本发明的目的是提供含有黄嘌呤衍生物或其药学上可接受的盐和脂肪酸或脂肪酸衍生物的容易吸收的口服制剂，其目的是提供含有可吸收性的黄嘌呤衍生物的容易吸收的口服制剂 通过在溶剂中溶解显示腺苷A1受体拮抗活性并具有利尿活性，肾保护活性，支气管扩张活性，脑功能改善活性，抗痴呆活性等的黄嘌呤衍生物而得到增强。

公开(公告)号：US20060205745A1

公开(公告)日：2006-09-14

申请号：US10554511

申请日：2004-05-07

申请人： Kazutoshi Kuroda ,  Noboru Aoki ,  Toshiro Ochiai ,  Akihiro Uchida ,  Yasuhiro Ishikawa ,  Makoto Kigoshi ,  Eiji Hayakawa

发明人： Kazutoshi Kuroda ,  Noboru Aoki ,  Toshiro Ochiai ,  Akihiro Uchida ,  Yasuhiro Ishikawa ,  Makoto Kigoshi ,  Eiji Hayakawa

IPC分类号： A61K31/522 ,  C07D473/02

CPC分类号： C07D473/06

摘要： Microcrystals of (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione having an average particle size of less than 50 μm; microcrystals of (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione having an average particle size of less than 50 μm and a crystallinity of 20% or more or the like, which possess excellent solubility, stability, bioavailability, dispersing property in a pharmaceutical formulation; and the like are provided. A solid pharmaceutical formulation which is characterized by comprising the same is also provided.

公开(公告)号：US06262508B1

公开(公告)日：2001-07-17

申请号：US09368425

申请日：1999-08-05

申请人： Juzaburo Shibayama ,  Noboru Aoki

发明人： Juzaburo Shibayama ,  Noboru Aoki

IPC分类号： H02K100

CPC分类号： H02K21/00 ,  H02K21/12 ,  H02K21/38

摘要： It is an object of the present invention to provide a rotary electrical device that can be manufactured easily, and which produces a high output torque at low operating speeds. The rotary electrical device comprises: a stator core. The rotary electrical device comprises: a stator core having Z1 stator slots for receiving three-phase windings which generate a rotational magnetic field of p magnetic pole pairs in the stator core, and Z1 permanent magnets being provided in tooth sections fabricated between the stator slots around the stator core; and a rotor core having Z2 permanent magnets being provided around the rotor core; wherein Z1, Z2 and p are related by an expression Z2=Z1±p, and direction of magnetic poles of all permanent magnets are aligned identically in a radial direction.

摘要翻译： 本发明的目的是提供一种可以容易地制造并且在低操作速度下产生高输出转矩的旋转电气装置。 旋转电气装置包括：定子铁心。旋转电气装置包括：具有Z1个定子槽的定子铁心，用于接收产生定子铁芯中的p个磁极对的旋转磁场的三相绕组，Z1永磁体是 设置在制造在定子芯周围的定子槽之间的齿部分中; 以及在转子铁心周围设置有Z2永磁铁的转子铁心; 其中Z1，Z2和p通过表达式Z2 = Z1±p相关联，并且所有永磁体的磁极方向在径向上相同地排列。

公开(公告)号：US4954743A

公开(公告)日：1990-09-04

申请号：US281259

申请日：1988-12-07

申请人： Takahiro Suzuki ,  Yuki Izuoka ,  Noboru Aoki

发明人： Takahiro Suzuki ,  Yuki Izuoka ,  Noboru Aoki

IPC分类号： H01T13/52 ,  H01T13/16 ,  H01T13/20 ,  H01T13/32 ,  H01T13/39

CPC分类号： H01T13/16 ,  H01T13/32 ,  H01T13/39

摘要： This invention provides an igniter plug, having a plurality of grooves within an outer surface of an annular ground electrode (2), the diameter of which is reduced to about 13 mm. Each groove (6) generally has a semi-circular shape in cross section to allow air flow along the grooves (6), with the number of the grooves (6) in the range from 4 to 16, and the width of each groove is to about 1.0 mm to 2.5 mm. The semi-circular cross section of the grooves (6) makes it possible to provide a large surface for the grooves without increasing the amount of machining, thus, enhancing cooling efficiency when the air flows along the grooves.

摘要翻译： 本发明提供一种点火器塞，其在环形接地电极（2）的外表面内具有多个凹槽，其直径减小到约13mm。 每个槽（6）的横截面通常具有半圆形形状，以允许空气沿槽（6）流动，槽（6）的数量在4至16的范围内，并且每个槽的宽度为 至约1.0mm至2.5mm。 槽（6）的半圆形横截面使得可以在不增加加工量的情况下为槽提供大的表面，从而当空气沿着槽流动时提高冷却效率。

公开(公告)号：US4951173A

公开(公告)日：1990-08-21

申请号：US280837

申请日：1988-12-07

申请人： Takahiro Suzuki ,  Yuki Izuoka ,  Noboru Aoki

发明人： Takahiro Suzuki ,  Yuki Izuoka ,  Noboru Aoki

IPC分类号： H01T13/20 ,  H01T13/52

CPC分类号： H01T13/52

摘要： This invention provides a creeping discharge type igniter plug, having a center electrode concentrically located within the center bore of the insulator. Near the lower portion of the center electrode is an annular space (6), formed between an outer surface of the center electrode and an inner surface of the semi-conductor ring (4). At the annular space (6), a lateral distance between the outer surface of the center electrode (2) and the inner surface of the semi-conductor ring (4), progressively decreases toward a lower end of the semi-conductor ring (4) thus, making it possible to maintain the least electrical resistance at a creeping discharge path defined from a lower end surface (3a) of the ground electrode (3) to a lower end surface (2a) of the center electrode (2) via a lower end surface (4b) of the semi-conductor ring (4).

摘要翻译： 本发明提供一种爬电放电型点火器插头，其中心电极同心地位于绝缘体的中心孔内。 在中心电极的下部附近是形成在中心电极的外表面和半导体环（4）的内表面之间的环形空间（6）。 在环形空间（6）处，中心电极（2）的外表面和半导体环（4）的内表面之间的横向距离朝向半导体环（4）的下端逐渐减小 ），使得可以在从接地电极（3）的下端面（3a）到中心电极（2）的下端面（2a）形成的沿面放电路径经由 半导体环（4）的下端面（4b）。

公开(公告)号：US07903268B2

公开(公告)日：2011-03-08

申请号：US10727977

申请日：2003-12-05

申请人： Noboru Aoki ,  Seiji Kageyama ,  Shinichi Kishi ,  Muneyoshi Akai ,  Susumu Hashimoto ,  Hiroshi Udo

发明人： Noboru Aoki ,  Seiji Kageyama ,  Shinichi Kishi ,  Muneyoshi Akai ,  Susumu Hashimoto ,  Hiroshi Udo

IPC分类号： G06F15/00

CPC分类号： G03G15/5012 ,  G06K15/00 ,  G06K2215/0085

摘要： As a user selects one of error recovery methods for each error category, and the selected method is stored in a memory. When an error occurs, an error recovery method corresponding to an error category of the error is detected. If the detected method is automatic print continuation, then the error is ignored and print operation is automatically continued. If the detected method is a recovery by user's operation, then an error message is displayed, and a procedure is performed in accordance with an instruction from the user.

摘要翻译： 当用户为每个错误类别选择一种错误恢复方法时，所选择的方法被存储在存储器中。 当发生错误时，检测到与错误的错误类别对应的错误恢复方法。 如果检测到的方法是自动打印继续，则会忽略错误，并自动继续打印操作。 如果检测到的方法是通过用户操作的恢复，则显示错误消息，并且根据来自用户的指令执行过程。