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    Oxadiazole derivatives and drugs containing these derivatives as the active ingredient
    5.
    发明申请
    Oxadiazole derivatives and drugs containing these derivatives as the active ingredient 审中-公开
    恶二唑衍生物和含有这些衍生物的药物作为活性成分

    公开(公告)号：US20070004642A1

    公开(公告)日：2007-01-04

    申请号：US11488782

    申请日：2006-07-19

    申请人： Kazuyuki Ohmoto ,  Iori Itagaki

    发明人： Kazuyuki Ohmoto ,  Iori Itagaki

    IPC分类号： A61K38/05 ,  A61K38/04 ,  C07K5/06 ,  C07K5/04 ,  C07D413/02

    CPC分类号： C07D271/07 ,  A61K38/00 ,  C07D271/113 ,  C07D413/06 ,  C07D413/12 ,  C07K5/06043 ,  C07K5/06139

    摘要： An oxadiazole derivative of formula (I) and a non-toxic salt thereof, wherein R is hydrogen, alkyl, CycA, etc.; AA1 is a single bond, amino acid residue, etc.; AA2 is a single bond, amino acid residue, etc.; R7 and R8 are hydrogen, alkyl, etc.; R9 is hydrogen, alkyl, etc.; R10 is hydrogen, alkyl, etc.). The compound of formula (I) has an inhibitory activity against cysteine protease and therefore it is useful as an agent for the prophylaxis and/or treatment of inflammatory diseases, diseases induced by apoptosis, diseases induced by disorders of immune responses, autoimmune diseases, diseases induced by decomposition of proteins which compose organism, shock, circulatory system disorders, blood coagulation system disorders, malignant tumors, acquired immune deficiency syndrome (AIDS) and AIDS-related complex (ARC), parasitic diseases, nerve degeneration diseases, pulmonary disorders, bone resorption diseases, endocrinesthenia, etc.

    摘要翻译： 式（I）的恶二唑衍生物及其无毒盐，其中R为氢，烷基，CycA等; AA 1是单键，氨基酸残基等; AA 2是单键，氨基酸残基等; R 7和R 8是氢，烷基等; R 9为氢，烷基等; R 10是氢，烷基等）。 式（I）化合物对半胱氨酸蛋白酶具有抑制活性，因此可用作预防和/或治疗炎性疾病，由凋亡诱导的疾病，由免疫应答障碍引起的疾病，自身免疫性疾病，疾病 由构成有机体的蛋白质，休克，循环系统疾病，凝血系统疾病，恶性肿瘤，获得性免疫缺陷综合征（AIDS）和AIDS相关复合物（ARC），寄生虫病，神经变性疾病，肺功能障碍，骨骼 吸收疾病，内分泌等

    1,3,4-oxadiazoline derivative and an agent comprising its derivative as active ingredient
    6.
    发明授权
    1,3,4-oxadiazoline derivative and an agent comprising its derivative as active ingredient 失效
    1,3,4-恶二唑啉衍生物和包含其衍生物作为活性成分的试剂

    公开(公告)号：US06797720B2

    公开(公告)日：2004-09-28

    申请号：US10148613

    申请日：2002-08-28

    申请人： Kazuyuki Ohmoto ,  Iori Itagaki

    发明人： Kazuyuki Ohmoto ,  Iori Itagaki

    IPC分类号： A61K314245

    CPC分类号： C07D271/113 ,  A61K38/00 ,  C07D271/12 ,  C07D413/12 ,  C07D417/12 ,  C07D493/08 ,  C07K5/06139

    摘要： A 1,3,4-oxadiazoline derivative of formula (I) wherein W is oxygen, sulfer; R is hydrogen, alkyl, CycA, etc.; AA1 is a single bond, amino acid residue, etc.; AA2 is a single bond, amino acid residue, etc.; R7 and R8 are hydrogen, alkyl, etc.; R9 is hydrogen, alkyl, etc., and a non-toxic salt thereof. The compound of formula (I) has an inhibitory activity against cysteine protease and therefore it is useful as an agent for the prophylaxis and/or treatment of inflammatory diseases, diseases induced by apoptosis, diseases induced by disorders of immune responses, autoimmune diseases, diseases induced by decomposition of proteins which compose organism, shock, circulatory system disorders, blood coagulation systems disorders, malignant tumors, acquired immune deficiency syndrome (AIDS) and AIDS-related complex (ARC), parasitic diseases, nerve degeneration diseases, pulmonary disorders, bone resorption diseases, endocrinesthenia, etc.

    摘要翻译： 式（I）的1,3,4-恶二唑啉衍生物，其中W是氧，硫醇; R是氢，烷基，CycA等; AA <1>是单键，氨基酸残基等; AA <2>是单键，氨基酸残基等; R 7和R 8是氢，烷基等; R 9是氢，烷基等，及其无毒盐。式（I）化合物对半胱氨酸蛋白酶具有抑制活性，因此可用作预防和/或治疗 炎症性疾病，由细胞凋亡引起的疾病，由免疫应答障碍引起的疾病，自身免疫性疾病，由构成生物体的蛋白质分解引起的疾病，休克，循环系统疾病，凝血系统疾病，恶性肿瘤，获得性免疫缺陷综合征（AIDS） 和艾滋病相关综合征（ARC），寄生虫病，神经变性疾病，肺功能障碍，骨吸收疾病，内分泌感染等。

    N-containing five-membered ring compounds and pharmaceutical agents comprising the same as active ingredient
    7.
    发明授权
    N-containing five-membered ring compounds and pharmaceutical agents comprising the same as active ingredient 失效
    含有N的五元环化合物和包含与活性成分相同的药剂

    公开(公告)号：US07390804B2

    公开(公告)日：2008-06-24

    申请号：US11018465

    申请日：2004-12-22

    申请人： Kazuyuki Ohmoto ,  Iori Itagaki

    发明人： Kazuyuki Ohmoto ,  Iori Itagaki

    IPC分类号： A61K31/535 ,  A61K31/445 ,  A61K31/44 ,  A61K31/41

    CPC分类号： C07D257/04 ,  A61K31/41 ,  A61K31/4245 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/5377 ,  C07D257/06 ,  C07D271/07 ,  C07D401/04 ,  C07D401/06 ,  C07D403/12 ,  C07D413/04 ,  C07D413/06

    摘要： An N-containing five-membered ring compound of formula (I) wherein all symbols are the same as described in the specification, and a non-toxic salt thereof. The compound of formula (I) has an inhibitory activity against cysteine protease and therefore it is useful as an agent for the prophylaxis and/or treatment of inflammatory diseases, diseases induced by apoptosis, diseases induced by disorders of immune responses, autoimmune diseases, diseases induced by decomposition of proteins which compose organism, shock, circulatory system disorders, blood coagulation systems disorders, malignant tumors, acquired immune deficiency syndrome (AIDS) and AIDS-related complex (ARC), parasitic diseases, nerve degeneration diseases, pulmonary disorders, bone resorption diseases, endocrinesthenia, etc.

    摘要翻译： 其中所有符号与说明书中所述相同的式（I）的含N的五元环化合物及其无毒盐。 式（I）化合物对半胱氨酸蛋白酶具有抑制活性，因此可用作预防和/或治疗炎性疾病，由凋亡诱导的疾病，由免疫应答障碍引起的疾病，自身免疫性疾病，疾病 由构成生物的蛋白质分解引起的，休克，循环系统疾病，凝血系统疾病，恶性肿瘤，获得性免疫缺陷综合征（AIDS）和AIDS相关复合物（ARC），寄生虫病，神经变性疾病，肺病，骨骼 吸收疾病，内分泌等