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公开(公告)号:US20090312249A1
公开(公告)日:2009-12-17
申请号:US12315989
申请日:2008-12-08
申请人: Keehoon Jung , HoMin Kim , Hak-Zoo Kim , Jung-Eun Lee , Gyun Min Lee , Sun Chang Kim , Jie-Oh Lee , Hak-Sung Kim , Gou Young Koh
发明人: Keehoon Jung , HoMin Kim , Hak-Zoo Kim , Jung-Eun Lee , Gyun Min Lee , Sun Chang Kim , Jie-Oh Lee , Hak-Sung Kim , Gou Young Koh
IPC分类号: A61K38/17 , C12N15/12 , C12N15/85 , C12N15/74 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/04 , C07K14/47 , A61P29/00 , A61P31/04
CPC分类号: C07K14/705 , C07K2319/32
摘要: The present application discloses a nucleic acid molecule encoding a fusion polypeptide capable of binding myeloid differentiation protein-2 (MD-2) polypeptide, which includes: a nucleotide sequence encoding an MD-2 polypeptide-binding portion of human toll-like receptor 4 (TLR4), a leucine-rich repeats (LRR) module, and a multimerizing component.
摘要翻译: 本申请公开了编码能够结合骨髓分化蛋白-2(MD-2)多肽的融合多肽的核酸分子,其包括:编码人类toll样受体4的MD-2多肽结合部分的核苷酸序列( TLR4),富含亮氨酸的重复序列(LRR)模块和多聚体组分。
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公开(公告)号:US20080242587A1
公开(公告)日:2008-10-02
申请号:US11932021
申请日:2007-10-31
申请人: Hak-Zoo Kim , Young Jun Koh , Ho-Min Kim , Keehoon Jung , Choonjoo Jeon , Gou Young Koh
发明人: Hak-Zoo Kim , Young Jun Koh , Ho-Min Kim , Keehoon Jung , Choonjoo Jeon , Gou Young Koh
IPC分类号: A61K38/02 , C07H21/04 , C12N15/63 , C12N5/16 , C12N1/19 , A61P9/00 , C12N1/21 , C07K2/00 , C12P21/02
CPC分类号: C07K14/71 , A61K38/00 , C07K2319/00
摘要: The present application discloses an isolated nucleic acid molecule encoding a polypeptide capable of synchronously binding VEGF polypeptide and Angiopoietin polypeptide, which includes a nucleotide sequence encoding a Tie2 component and a VEGFR component.
摘要翻译: 本申请公开了编码能够同时结合VEGF多肽和促血管生成素多肽的分离的核酸分子,其包括编码Tie2组分和VEGFR组分的核苷酸序列。
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公开(公告)号:US10259860B2
公开(公告)日:2019-04-16
申请号:US11932021
申请日:2007-10-31
申请人: Hak-Zoo Kim , Young Jun Koh , Ho-Min Kim , Keehoon Jung , Choonjoo Jeon , Gou Young Koh
发明人: Hak-Zoo Kim , Young Jun Koh , Ho-Min Kim , Keehoon Jung , Choonjoo Jeon , Gou Young Koh
摘要: The present application discloses an isolated nucleic acid molecule encoding a polypeptide capable of synchronously binding VEGF polypeptide and Angiopoietin polypeptide, which includes a nucleotide sequence encoding a Tie2 component and a VEGFR component.
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