公开(公告)号：US06230037B1

公开(公告)日：2001-05-08

申请号：US09035827

申请日：1998-03-06

申请人： Keiji Tsukada ,  Akihiko Kandori ,  Kenichi Okajima ,  Hitoshi Sasabuchi ,  Hiroyuki Suzuki ,  Shoji Kondo ,  Yasuaki Komiyama

发明人： Keiji Tsukada ,  Akihiko Kandori ,  Kenichi Okajima ,  Hitoshi Sasabuchi ,  Hiroyuki Suzuki ,  Shoji Kondo ,  Yasuaki Komiyama

IPC分类号： A61B505

CPC分类号： A61B5/04005 ,  G01R33/0354 ,  G01R33/10

摘要： A biomagnetic field measuring apparatus has a plurality of fluxmeters disposed externally of a living body and each including a superconducting quantum interference device (SQUID) for detecting a biomagnetic field generated from the living body, the plurality of fluxmeters being operative to detect a temporal change of a component of the biomagnetic field in a first direction which is normal to the surface of the living body, an operation processor for performing computation for determining a temporal change of a value proportional to a root of square sum of differential values of the first-direction magnetic field component in second and third directions which cross the first direction and computation for integrating the temporal change of the value over a predetermined interval to determine an integral value, and a display for displaying the determined integral value. Distribution of magnetic fields generated from the heart is determined with a small number of fluxmeters.

摘要翻译： 生物磁场测量装置具有设置在生物体的外部的多个磁通量计，每个磁通量计包括用于检测从生物体产生的生物磁场的超导量子干涉装置（SQUID），所述多个磁通量计可操作以检测时间变化 与生物体表面正交的第一方向的生物磁场的分量，运算处理器，用于进行计算，以确定与第一方向的差分值的平方和的根数成比例的值的时间变化 与第一方向交叉的第二方向和第三方向的磁场分量和用于对预定间隔内的值的时间变化进行积分的运算以确定积分值，以及用于显示所确定的积分值的显示。 由心脏产生的磁场的分布由少量的磁通计确定。

公开(公告)号：US06735460B2

公开(公告)日：2004-05-11

申请号：US10189010

申请日：2002-07-05

申请人： Keiji Tsukada ,  Akihiko Kandori ,  Kenichi Okajima ,  Hitoshi Sasabuchi ,  Hiroyuki Suzuki ,  Shoji Kondo ,  Yasuaki Komiyama

发明人： Keiji Tsukada ,  Akihiko Kandori ,  Kenichi Okajima ,  Hitoshi Sasabuchi ,  Hiroyuki Suzuki ,  Shoji Kondo ,  Yasuaki Komiyama

IPC分类号： A61B505

CPC分类号： A61B5/04005 ,  G01R33/0354 ,  G01R33/10

摘要： A biomagnetic field measuring apparatus has a plurality of fluxmeters disposed externally of a living body and each including a superconducting quantum interference device (SQUID) for detecting a biomagnetic field generated from the living body, the plurality of fluxmeters being operative to detect a temporal change of a component of the biomagnetic field in a first direction which is vertical to the surface of the living body, an operation processor for performing computation for determining a temporal change of a value proportional to a root of square sum of differential value of the first-direction magnetic field component in second and third directions which cross the first direction and computation for integrating the temporal change of the value over a predetermined interval to determine an integral value, and a display for displaying the determined integral value. Distribution of magnetic fields generated from the heart is determined with a small number of fluxmeters.

摘要翻译： 生物磁场测量装置具有设置在生物体的外部的多个磁通量计，每个磁通量计包括用于检测从生物体产生的生物磁场的超导量子干涉装置（SQUID），所述多个磁通量计可操作以检测时间变化 生物磁场在与活体表面垂直的第一方向上的分量;运算处理器，用于执行计算，以确定与第一方向的差分值的平方和的根数成正比的值的时间变化 与第一方向交叉的第二方向和第三方向的磁场分量和用于对预定间隔内的值的时间变化进行积分的运算以确定积分值，以及用于显示所确定的积分值的显示。 由心脏产生的磁场的分布由少量的磁通计确定。

公开(公告)号：US06539245B2

公开(公告)日：2003-03-25

申请号：US09793600

申请日：2001-02-27

申请人： Keiji Tsukada ,  Akihiko Kandori ,  Kenichi Okajima ,  Hitoshi Sasabuchi ,  Hiroyuki Suzuki ,  Shoji Kondo ,  Yasuaki Komiyama

发明人： Keiji Tsukada ,  Akihiko Kandori ,  Kenichi Okajima ,  Hitoshi Sasabuchi ,  Hiroyuki Suzuki ,  Shoji Kondo ,  Yasuaki Komiyama

IPC分类号： A61B505

CPC分类号： A61B5/04005 ,  G01R33/0354 ,  G01R33/10

摘要： A biomagnetic field measuring apparatus has a plurality of fluxmeters disposed externally of a living body and each including a superconducting quantum interference device (SQUID) for detecting a biomagnetic field generated from the living body, the plurality of fluxmeters being operative to detect a temporal change of a component of the biomagnetic field in a first direction which is vertical to the surface of the living body, an operation processor for performing computation for determining a temporal change of a value proportional to a root of square sum of differential value of the first-direction magnetic field component in second and third directions which cross the first direction and computation for integrating the temporal change of the value over a predetermined interval to determine an integral value, and a display for displaying the determined integral value. Distribution of magnetic fields generated from the heart is determined with a small number of fluxmeters.

公开(公告)号：US07403809B2

公开(公告)日：2008-07-22

申请号：US10810812

申请日：2004-03-29

申请人： Keiji Tsukada ,  Akihiko Kandori ,  Kenichi Okajima ,  Hitoshi Sasabuchi ,  Hiroyuki Suzuki ,  Shoji Kondo ,  Yasuaki Komiyama

发明人： Keiji Tsukada ,  Akihiko Kandori ,  Kenichi Okajima ,  Hitoshi Sasabuchi ,  Hiroyuki Suzuki ,  Shoji Kondo ,  Yasuaki Komiyama

IPC分类号： A61B5/05

CPC分类号： A61B5/04005 ,  G01R33/0354 ,  G01R33/10

摘要： A biomagnetic field measuring apparatus has a plurality of fluxmeters disposed externally of a living body and each including a superconducting quantum interference device (SQUID) for detecting a biomagnetic field generated from the living body, the plurality of fluxmeters being operative to detect a temporal change of a component of the biomagnetic field in a first direction which is vertical to the surface of the living body, an operation processor for performing computation for determining a temporal change of a value proportional to a root of square sum of differential value of the first-direction magnetic field component in second and third directions which cross the first direction and computation for integrating the temporal change of the value over a predetermined interval to determine an integral value, and a display for displaying the determined integral value. Distribution of magnetic fields generated from the heart is determined with a small number of fluxmeters.

摘要翻译： 生物磁场测量装置具有设置在生物体的外部的多个磁通量计，每个磁通量计包括用于检测从生物体产生的生物磁场的超导量子干涉装置（SQUID），所述多个磁通量计可操作以检测时间变化 生物磁场在与活体表面垂直的第一方向上的分量;运算处理器，用于执行计算，以确定与第一方向的差分值的平方和的根数成正比的值的时间变化 与第一方向交叉的第二方向和第三方向的磁场分量和用于对预定间隔内的值的时间变化进行积分的运算以确定积分值，以及用于显示所确定的积分值的显示。 由心脏产生的磁场的分布由少量的磁通计确定。

公开(公告)号：US06269262B1

公开(公告)日：2001-07-31

申请号：US09094690

申请日：1998-06-15

申请人： Akihiko Kandori ,  Keiji Tsukada ,  Ryuichi Shinomura ,  Hiroyuki Suzuki ,  Hitoshi Sasabuchi ,  Shoji Kondo ,  Yasuaki Komiyama ,  Kenji Teshigawara

发明人： Akihiko Kandori ,  Keiji Tsukada ,  Ryuichi Shinomura ,  Hiroyuki Suzuki ,  Hitoshi Sasabuchi ,  Shoji Kondo ,  Yasuaki Komiyama ,  Kenji Teshigawara

IPC分类号： A61B505

CPC分类号： A61B5/04005 ,  A61B5/0046 ,  A61B8/4416

摘要： A biomagnetic field measurement apparatus includes a bed which holds a subject to be inspected in a shielded room. A cryostat holds a plurality of SQUID magnetometers at low temperature. The cryostat is arranged in the shielded room and the plurality of SQUID magnetometers detect a magnetic field generated from the subject. A driving and detecting circuit drives the plurality of SQUID magnetometers and detects signals therefrom that are processed by a computer. A display that is arranged in the shielded room displays data for viewing by an operator.

摘要翻译： 生物磁场测量装置包括在屏蔽室中保持被检查对象的床。 低温恒温器在低温下保持多个SQUID磁力计。 低温恒温器布置在屏蔽室中，并且多个SQUID磁力计检测从被检体产生的磁场。 驱动和检测电路驱动多个SQUID磁力计并检测由计算机处理的信号。 布置在屏蔽室中的显示器显示用于操作者观看的数据。

公开(公告)号：US06628978B1

公开(公告)日：2003-09-30

申请号：US09424622

申请日：1999-11-24

申请人： Shoji Kondo ,  Hitoshi Sasabuchi ,  Hiroyuki Suzuki ,  Keiji Tsukada ,  Akihiko Kandori

发明人： Shoji Kondo ,  Hitoshi Sasabuchi ,  Hiroyuki Suzuki ,  Keiji Tsukada ,  Akihiko Kandori

IPC分类号： A61B505

CPC分类号： A61B5/6835 ,  A61B5/0064 ,  A61B5/04005 ,  A61B5/704 ,  A61B6/0407 ,  A61B6/08

摘要： In the present invention, when measuring magnetism of a measuring portion of a patient by making use of a dewar incorporating magnetism sensors each including a super conducting quantum interference device, a bed is at first positioned outside a position immediately below the dewar. At this position outside the position immediately below the dewar the patient is laid on the bed in an inspection posture. Marks are attached on the body of the patient at three points for setting X and Y axis coordinate on the measurement portion, at the position outside the position immediately below the dewar cross shaped beam patterns are projected and the position of the bed is adjusted so that the marks at the three points locate on the cross shaped beam patterns, thereafter, bed is transferred by a constant amount to the position immediately below the dewar. Thereby, in the biomagnetism measurement the correlated position between the dewar (magnetism sensors) and the measurement portion of the patient can be ascertained easily and accurately.

摘要翻译： 在本发明中，当通过使用包含超导量子干涉装置的包含磁传感器的杜瓦瓶来测量患者的测量部分的磁性时，床首先位于杜瓦瓶正下方的位置之外。 在位于杜瓦瓶正下方的位置之外的位置处，患者以检查姿势放置在床上。 标记在三个点处附着在患者身体上，用于在测量部分上设置X和Y轴坐标，在杜绝十字形横梁图案的正下方的位置之外的位置处，并调整床的位置，使得 三点处的标记位于十字形梁的图案上，此后，将床以恒定的量转移到杜瓦瓶正下方的位置。 因此，在生物磁测量中，可以容易且精确地确定杜瓦瓶（磁传感器）与患者的测量部分之间的相关位置。

公开(公告)号：US06522908B1

公开(公告)日：2003-02-18

申请号：US09678654

申请日：2000-10-04

申请人： Tsuyoshi Miyashita ,  Keiji Tsukada ,  Akihiko Kandori ,  Shoji Kondo ,  Hitoshi Sasabuchi

发明人： Tsuyoshi Miyashita ,  Keiji Tsukada ,  Akihiko Kandori ,  Shoji Kondo ,  Hitoshi Sasabuchi

IPC分类号： A61B505

CPC分类号： A61B5/0064 ,  A61B5/0044 ,  A61B5/04005 ,  A61B5/704

摘要： First and second markers are disposed respectively on the processus xiphoideus and the incisura jugularis of the subject to be inspected. The chest of the subject is positioned below the cryostat so that a line joining the first and second markers extends in one direction in which sensors are arranged in the interior of the cryostat. Processing includes (1) forming, from magnetic waveform signals, an image representing the activity of the heart of the subject, (2) making the pixel size of a morphological image, including the heart photographed by an image pickup device, coincident with the pixel size of functional information and forming a functional image equal in pixel size to the morphological image, (3) making the position of the first marker in the functional image and the position of the first marker in the morphological image coincident, and (4) combining the functional image and the morphological image.

摘要翻译： 分别将第一和第二标记物放置在待检查对象的xiphoideus和incisura jugularis上。 受试者的胸部定位在低温恒温器下方，使得连接第一和第二标记的线在传感器布置在低温恒温器的内部的一个方向上延伸。 处理包括：（1）从磁波形信号形成表示被摄体心脏的活动的图像，（2）使由包括由图像摄取装置拍摄的心脏的形态学图像的像素尺寸与像素 功能信息的大小和像素尺寸相等于形态图像的功能图像，（3）使功能图像中的第一标记的位置和形态图像中的第一标记的位置一致，以及（4）组合 功能图像和形态图像。

公开(公告)号：US06842637B2

公开(公告)日：2005-01-11

申请号：US09948857

申请日：2001-09-10

申请人： Keiji Tsukada ,  Akihiko Kandori ,  Tsuyoshi Miyashita ,  Hiroyuki Suzuki ,  Hitoshi Sasabuchi

发明人： Keiji Tsukada ,  Akihiko Kandori ,  Tsuyoshi Miyashita ,  Hiroyuki Suzuki ,  Hitoshi Sasabuchi

IPC分类号： A61B5/04 ,  A61B5/0444 ,  G01R33/02 ,  G01R33/035 ,  A61B5/05

CPC分类号： A61B5/04005 ,  A61B5/04008 ,  A61B5/0444 ,  G01R33/0206 ,  G01R33/0358

摘要： A magnetic field measurement apparatus includes a plurality of magnetometers each having SQUID's and three detection coils, one of which detects each of three orthogonal directional magnetic field components (Bx, By, Bz) of a magnetic field generated from a subject to be inspected, a display which displays time variation of waveforms of the magnitude (√(Bx2+By2+Bz2)) of magnetic field synthesized by square sum of each of the three orthogonal directional magnetic field components of the magnetic field generated from the subject to be inspected, a holder for holding a Dewar's vessel for arranging magnetometers therein, and a controller for controlling a positional relationship between the subject to be inspected and the Dewar's vessel. Accurate time variation of the magnetic field generated from the subject to be inspected can be detected without influence of positional change of the subject to be inspected, by simultaneously measuring each of the three orthogonal directional magnetic field components (Bx, By, Bz) of the magnetic field generated from current sources in the subject to be inspected.

摘要翻译： 磁场测量装置包括多个具有SQUID和三个检测线圈的磁力计，其中一个检测线圈检测从被检查对象产生的磁场的三个正交方向磁场分量（Bx，By，Bz）中的每一个， 显示器，其显示由磁场的三个正交方向磁场分量中的每一个的平方和合成的磁场的幅度（√（Bx2 + By2 + Bz2））的波形的时间变化 从被检查对象产生的持有人，用于在其中放置磁力计的Dewar的血管的持有人，以及用于控制待检查对象与Dewar的血管之间的位置关系的控制器。 通过同时测量被检查对象的三个正交方向磁场分量（Bx，By，Bz）中的每一个，可以检测从待检查对象产生的磁场的精确时间变化，而不受被检查对象的位置变化的影响 从被检查对象的电流源产生的磁场。

公开(公告)号：US06275719B1

公开(公告)日：2001-08-14

申请号：US09293885

申请日：1999-04-19

申请人： Akihiko Kandori ,  Tsuyoshi Miyashita ,  Keiji Tsukada ,  Hitoshi Sasabuchi ,  Hiroyuki Suzuki

发明人： Akihiko Kandori ,  Tsuyoshi Miyashita ,  Keiji Tsukada ,  Hitoshi Sasabuchi ,  Hiroyuki Suzuki

IPC分类号： A61B505

CPC分类号： A61B5/04007 ,  A61B5/02411

摘要： A biomagnetic field measurement apparatus comprises, a plurality of magnetometers each having a SQUID sensor and a detection coil and each detecting a magnetic field generated from a heart of a fetus in a mother; a processor processing magnetic field wave forms detected by the magnetometers; and a display displaying results obtained by the processor. The processor estimates a position of a current dipole from the magnetic field wave forms, and processes projecting the position of the current dipole on a first plane parallel to a plane on which one ends of the magnetometers are disposed on processes projecting the position of the current dipole on a second plane perpendicular to the plane on which the one ends of the magnetometers are disposed. The position of the current dipole projected on the first plane and the position of the current dipole projected on the second plane are displayed on the display.

摘要翻译： 生物磁场测量装置包括：多个磁力计，每个磁力计具有SQUID传感器和检测线圈，并且各自检测从母体的胎儿的心脏产生的磁场; 由磁力计检测到的处理器处理磁场波形的处理器; 以及显示由处理器获得的结果的显示。 处理器估计来自磁场波形的当前偶极子的位置，并且处理将电流偶极子的位置投影在平行于其上的磁力计的一端上的平面的第一平面上，该平面位于突出电流位置的过程 偶极子在垂直于其上放置磁力计的一端的平面的第二平面上。 投影在第一平面上的当前偶极子的位置和投影在第二平面上的当前偶极子的位置显示在显示器上。

公开(公告)号：US06609019B1

公开(公告)日：2003-08-19

申请号：US09493798

申请日：2000-01-28

申请人： Kenji Teshigawara ,  Hiroyuki Suzuki ,  Keiji Tsukada ,  Kazuhisa Machida ,  Akihiko Kandori ,  Tsuyoshi Miyashita ,  Hitoshi Sasabuchi

发明人： Kenji Teshigawara ,  Hiroyuki Suzuki ,  Keiji Tsukada ,  Kazuhisa Machida ,  Akihiko Kandori ,  Tsuyoshi Miyashita ,  Hitoshi Sasabuchi

IPC分类号： A61B505

CPC分类号： A61B5/04007 ,  A61B5/0402 ,  A61B5/742

摘要： The present invention, in the physiological magnetic field measuring instrument, recognizes characteristic waveforms (for example, heart beats) repeatedly appearing by physiological activity from measured signal waveforms, registers one of measured heart beats as a reference waveform, evaluates the difference degree of each measured heart beat data from the reference waveform, and executes the averaging process using only waveforms whose difference degrees are less than the allowable value. The present invention registers waveforms whose difference degrees are more than the allowable value as abnormal data and puts them into the display enabled state. Discrimination information is as signed to measurement conditions necessary for measuring the physiological magnetic field and data analysis conditions and when the discrimination information is designated for measurement, the measurement conditions and analysis conditions can be read. By doing this, the physiological magnetic field measuring instrument independently selects good or defective data automatically, and a reliable automatic averaging process can be obtained, and the data processing and operation can be simplified.

摘要翻译： 本发明在生理磁场测量仪器中，从测量信号波形中识别由生理活动重复出现的特征波形（例如，心跳），将测量的心跳中的一个记录为参考波形，评估每个测量的差异程度 从参考波形心跳数据，并且仅使用差值小于允许值的波形执行平均处理。 本发明将差异度大于容许值的波形记录为异常数据，并将其置于显示使能状态。 鉴别信息符合测量生理磁场和数据分析条件所需的测量条件，并且当识别信息被指定用于测量时，可以读取测量条件和分析条件。 通过这样做，生理磁场测量仪器自动选择好的或有缺陷的数据，可以获得可靠的自动平均过程，可以简化数据处理和操作。