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    3(2H)pyridazinone, and antagonistic agent against SRS-A containing it
    2.
    发明授权
    3(2H)pyridazinone, and antagonistic agent against SRS-A containing it 失效
    3（2H）哒嗪酮，和含有它的SRS-A拮抗剂

    公开(公告)号：US4978665A

    公开(公告)日：1990-12-18

    申请号：US144173

    申请日：1988-01-15

    申请人： Keizo Tanikawa ,  Ryozo Sakoda ,  Ken-ichi Shikada ,  Sakuya Tanaka

    发明人： Keizo Tanikawa ,  Ryozo Sakoda ,  Ken-ichi Shikada ,  Sakuya Tanaka

    IPC分类号： A61K31/50 ,  A61P37/08 ,  C07D237/22

    CPC分类号： C07D237/22

    摘要： A 3(2H)pyridazinone of the formula: ##STR1## wherein R.sub.1 is hydrogen, 2-propenyl or straight chained or branched C.sub.1 -C.sub.4 alkyl; R.sub.2 is hydrogen or C.sub.1 -C.sub.3 alkyl; X is chlorine or bromine; Y is hydrogen, nitro, -NHR.sub.3 wherein R.sub.3 is hydrogen or straight chained or branched C.sub.1 -C.sub.4 alkyl, -AR.sub.4 wherein A is oxygen or sulfur and R.sub.4 is hydrogen, straight chained or branched C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 alkenyl having one double bond, C.sub.3 -C.sub.6 alkynyl having one triple bond, phenyl or ##STR2## wherein R.sub.5 is hydrogen or C.sub.1 -C.sub.4 alkyl, or halogen; Z.sub.1 is hydrogen, C.sub.1 -C.sub.4 alkyl, -OR.sub.6 wherein R.sub.6 is hydrogen, straight chained or branched C.sub.1 -C.sub.8 alkyl or ##STR3## wherein n is an integer of from 1 to 4, -N(R.sub.7).sub.2 wherein R.sub.7 is C.sub.1 -C.sub.4 alkyl, or halogen; Z.sub.2 is C.sub.1 -C.sub.4 alkyl, -OR.sub.6 wherein R.sub.6 is as defined above, -N(R.sub.7).sub.2 wherein R.sub.7 is as defined above, or halogen, provided that when R.sub.1 is straight chained or branched C.sub.2 -C.sub.4 alkyl, Y is not hydrogen and when R.sub.1 is hydrogen, methyl or 2-propenyl, Y and R.sub.2 are not simultaneously hydrogen, or a pharmaceutically acceptable salt thereof.

    Valerolactone compounds and perfume composition
    3.
    发明授权
    Valerolactone compounds and perfume composition 有权
    缬草内酯化合物和香料组合物

    公开(公告)号：US07491833B2

    公开(公告)日：2009-02-17

    申请号：US10529290

    申请日：2003-09-26

    申请人： Sakuya Tanaka ,  Kazuyuki Fukuda ,  Takahiro Asada

    发明人： Sakuya Tanaka ,  Kazuyuki Fukuda ,  Takahiro Asada

    IPC分类号： C07D309/00 ,  A61Q13/00

    CPC分类号： C07D315/00 ,  A23L27/2052 ,  C07D263/58 ,  C07D309/30 ,  C11B9/008

    摘要： A valerolactone compound represented by the formula (I): wherein each of R1 and R2 is independently a hydrogen atom, a methyl group or an ethyl group wherein when R1 is a hydrogen atom, R2 is not a hydrogen atom; and wherein when R2 is a hydrogen atom, R1 is not a hydrogen atom, R3 is a hydrogen atom or a methyl group, and R4 is a propyl group, a 1-propenyl group or a phenyl group; a valerolactone compound represented by the formula (II): a process for preparing the same; and a perfume composition comprising the above-mentioned valerolactone compound.

    摘要翻译： 由式（I）表示的戊内酯化合物：其中R 1和R 2各自独立地为氢原子，甲基或乙基，其中当R 1为氢原子时，R 2不为氢原子; 并且其中当R 2是氢原子时，R 1不是氢原子，R 3是氢原子或甲基，R 4是丙基，1-丙烯基或苯基; 由式（II）表示的戊内酯化合物：其制备方法; 和包含上述戊内酯化合物的香料组合物。

    Valerolactone compounds and perfume composition
    4.
    发明申请
    Valerolactone compounds and perfume composition 有权
    缬草内酯化合物和香料组合物

    公开(公告)号：US20060258559A1

    公开(公告)日：2006-11-16

    申请号：US10529290

    申请日：2003-09-26

    申请人： Sakuya Tanaka ,  Kazuyuki Fukuda ,  Takahiro Asada

    发明人： Sakuya Tanaka ,  Kazuyuki Fukuda ,  Takahiro Asada

    IPC分类号： A61Q13/00

    CPC分类号： C07D315/00 ,  A23L27/2052 ,  C07D263/58 ,  C07D309/30 ,  C11B9/008

    摘要： A valerolactone compound represented by the formula (I): wherein each of R1 and R2 is independently a hydrogen atom, a methyl group or an ethyl group wherein when R1 is a hydrogen atom, R2 is not a hydrogen atom; and wherein when R2 is a hydrogen atom, R1 is not a hydrogen atom, R3 is a hydrogen atom or a methyl group, and R4 is a propyl group, a 1-propenyl group or a phenyl group; a valerolactone compound represented by the formula (II): a process for preparing the same; and a perfume composition comprising the above-mentioned valerolactone compound.

    摘要翻译： 由式（I）表示的戊内酯化合物：其中R 1和R 2各自独立地为氢原子，甲基或乙基，其中当R 1， SUP> 1 是氢原子，R 2不是氢原子; 并且其中当R 2是氢原子时，R 1不是氢原子，R 3是氢原子或甲基， R 4是丙基，1-丙烯基或苯基; 由式（II）表示的戊内酯化合物：其制备方法; 和包含上述戊内酯化合物的香料组合物。

    Dihydropyridine-5-phosphonic acid cyclic propylene ester
    5.
    发明授权
    Dihydropyridine-5-phosphonic acid cyclic propylene ester 失效
    二氢吡啶-5-膦酸环丙烯酯

    公开(公告)号：US4885284A

    公开(公告)日：1989-12-05

    申请号：US851158

    申请日：1986-04-14

    申请人： Kiyotomo Seto ,  Sakuya Tanaka ,  Ryozo Sakoda

    发明人： Kiyotomo Seto ,  Sakuya Tanaka ,  Ryozo Sakoda

    IPC分类号： C07F9/6571

    CPC分类号： C07F9/657181

    摘要： A compound of the formula: ##STR1## wherein each of R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 which may be the same or different, is hydrogen or C.sub.1 -C.sub.4 alkyl; one of X.sup.1 and X.sup.2 is nitro, fluroine, chlorine, difluoromethyoxy or trifluoromethyl and the other is hydrogen, or both of X.sup.1 and X.sup.2 are chlorine; and Y is ##STR2## wherein A is C.sub. -C.sub.6 alkylene, each of Ar.sup.1 and Ar.sup.2 which may be the same or different, is phenyl which may be substituted by chlorine, fluorine or C.sub.1 -C.sub.3 alkoxy, and m is an integer of from 0 to 4, or Y is ##STR3## wherein A, Ar.sup.1 and Ar.sup.2 are as defined above when that both X.sup.1 and X.sup.2 are chlorine; or a pharmaceutically acceptable salt thereof.

    摘要翻译： 下式的化合物：其中R 1，R 2，R 3，R 4，R 5和R 6可以相同或不同的是氢或C 1 -C 4烷基; X1和X2之一是硝基，氟，氯，二氟甲氧基或三氟甲基，另一个是氢，或者X1和X2都是氯; 并且Y为其中A为C-C6亚烷基，Ar1和Ar2可以相同或不同，为可被氯，氟或C1-C3烷氧基取代的苯基，m为 0〜4，或Y为，其中当X1和X2都为氯时，A，Ar1和Ar2如上定义; 或其药学上可接受的盐。

    Antihypertensive dihydropyridine-5-phosphonic acid cyclic esters
    6.
    发明授权
    Antihypertensive dihydropyridine-5-phosphonic acid cyclic esters 失效
    抗高血压二氢吡啶-5-膦酸环酯

    公开(公告)号：US4576934A

    公开(公告)日：1986-03-18

    申请号：US654473

    申请日：1984-09-26

    申请人： Kiyotomo Seto ,  Sakuya Tanaka ,  Ryozo Sakoda

    发明人： Kiyotomo Seto ,  Sakuya Tanaka ,  Ryozo Sakoda

    IPC分类号： C07D211/90 ,  C07F9/59 ,  C07F9/6571 ,  C07F9/6574 ,  C07F9/58 ,  A61K31/675

    CPC分类号： C07D211/90 ,  C07F9/59 ,  C07F9/597 ,  C07F9/657181 ,  C07F9/65742

    摘要： A compound of the formula: ##STR1## where X is hydrogen, nitro, trifluoromethyl, fluorine, chlorine, bromine or iodine; A is 1,3-propylene or 1,4-butylene which may be substituted by C.sub.1 -C.sub.3 alkyl, R is C.sub.1 -C.sub.4 alkyl, --Y--N(R.sup.1)(R.sup.2) or ##STR2## where each of R.sup.1, R.sup.2 and R.sup.3, which may be the same or different are hydrogen, C.sub.1 -C.sub.6 alkyl, or aralkyl, and Y is C.sub.2 -C.sub.6 alkylene, and Me is methyl, or its pharmaceutically acceptable salt. These compounds have utility as anti-hypertensive agents and coronary or peripheral vasodilators.

    摘要翻译： 下式的化合物：其中X是氢，硝基，三氟甲基，氟，氯，溴或碘; A是可以被C 1 -C 3烷基取代的1,3-亚丙基或1,4-亚丁基，R是C 1 -C 4烷基，-YN（R 1）（R 2）或者其中每个R 1，R 2和R 3 可以相同或不同的是氢，C 1 -C 6烷基或芳烷基，Y是C 2 -C 6亚烷基，Me是甲基或其药学上可接受的盐。 这些化合物可用作抗高血压剂和冠状或外周血管扩张剂。

    Citral acetal
    9.
    发明授权
    Citral acetal 有权
    柠檬醛缩醛

    公开(公告)号：US06506793B2

    公开(公告)日：2003-01-14

    申请号：US09973017

    申请日：2001-10-10

    申请人： Sakuya Tanaka ,  Shigeyoshi Tanaka ,  Shunichi Akiba ,  Katsutoshi Ara ,  Hirohiko Ishida

    发明人： Sakuya Tanaka ,  Shigeyoshi Tanaka ,  Shunichi Akiba ,  Katsutoshi Ara ,  Hirohiko Ishida

    IPC分类号： A61K31335

    CPC分类号： C07D317/22 ,  A61K8/4973 ,  A61K2800/782 ,  A61Q13/00 ,  A61Q15/00 ,  A61Q19/00

    摘要： The present invention provides a citral acetal capable of sustaining a lemon aroma unique to citral and a perfume composition comprising the citral acetal, as well as an LDH inhibitor and a deodorant, cosmetics and a skin agent for external application, comprising the LDH inhibitor. The citral acetal of the present invention is represented by formula (1): wherein the wavy line represents a cis and/or trans form, and R represents a C1, to C9, linear or branched alkyl group.

    摘要翻译： 本发明提供了能够维持柠檬醛独特的柠檬香气和包含柠檬醛缩醛的香料组合物的柠檬醛缩醛，以及包含LDH抑制剂的LDH抑制剂和用于外用的除臭剂，化妆品和皮肤剂。 本发明的柠檬醛缩醛由式（1）表示：其中波浪线表示顺式和/或反式，R表示C1至C9直链或支链烷基。