公开(公告)号：US20150374998A1

公开(公告)日：2015-12-31

申请号：US14849351

申请日：2015-09-09

申请人： Kellie S. FLETCHER ,  Benjamin David PLESS ,  Anthony V. CAPARSO ,  Kenneth N. HORNE

发明人： Kellie S. FLETCHER ,  Benjamin David PLESS ,  Anthony V. CAPARSO ,  Kenneth N. HORNE

IPC分类号： A61N1/36 ,  G06F19/00

CPC分类号： A61N1/37247 ,  A61N1/36075 ,  A61N1/36128 ,  A61N1/36142 ,  A61N1/37241 ,  A61N1/37282 ,  G16H40/63

摘要： Methods and apparatus for delivering therapy from an implanted neurostimulator to a patient are provided. One feature is an external controller that acts as a gateway for therapy. The external controller can be a handheld controller that communicates wirelessly with the implanted neurostimulator. In some embodiments, the controller communicates with a database to determine a therapy approval status of the neurostimulator. Therapy can be approved by a physician prescription, or by prepayment, for example. In some embodiments, the neurostimulator is deactivated when no approved therapies remain.

摘要翻译： 提供了从植入的神经刺激器向患者递送治疗的方法和装置。 一个特点是外部控制器充当治疗的门户。 外部控制器可以是与植入的神经刺激器无线通信的手持控制器。 在一些实施例中，控制器与数据库通信以确定神经刺激器的治疗批准状态。 治疗可以由医生处方批准，或通过预付款来批准。 在一些实施例中，当没有批准的治疗保留时，神经刺激器被停用。

公开(公告)号：US20110098640A1

公开(公告)日：2011-04-28

申请号：US12910572

申请日：2010-10-22

申请人： Kenneth N. HORNE ,  Gregory J.R. Spooner ,  John A. Scholl ,  John T. Santini, JR.

发明人： Kenneth N. HORNE ,  Gregory J.R. Spooner ,  John A. Scholl ,  John T. Santini, JR.

IPC分类号： A61M31/00 ,  A61F9/00 ,  A61K31/573 ,  A61P27/02 ,  A61P9/10 ,  A61P27/06 ,  A61P35/00 ,  A61P27/12

CPC分类号： A61F9/0017 ,  A61F2002/30714 ,  A61F2250/0068 ,  A61F2250/0089 ,  A61F2250/0097 ,  A61K9/0009 ,  A61K9/0051

摘要： The present disclosure relates to methods for visualizing the opening of a drug reservoir of an implantable medical device. In particular, the present disclosure provides methods for observing the release or exposure of contents from a drug reservoir of a medical device placed within the vitreous of an eye of a subject. The methods include implanting a drug delivery device within an anatomy of a subject. The drug device includes a plurality of reservoirs, each loaded with a therapeutic agent and a marker. Furthermore, the drug delivery device comprises a plurality of barrier layers for separating the contents of one of the plurality of reservoirs from the anatomy. The method further includes irradiating at least one of the plurality of barrier layers such that at least one of the plurality of reservoirs is breached, thereby triggering release of the therapeutic agent and the marker from the device. By visually detecting release of the marker into the anatomy, release of the therapeutic agent into the anatomy is verified.

摘要翻译： 本公开涉及用于可视化可植入医疗装置的药物储存器的开口的方法。 特别地，本公开提供了观察从放置在受试者的眼睛的玻璃体内的医疗装置的药物储存器释放或暴露内容物的方法。 所述方法包括将药物递送装置植入受试者的解剖结构内。 药物装置包括多个储存器，每个储存器装载有治疗剂和标记物。 此外，药物递送装置包括用于将多个储存器中的一个的内容物与解剖结构分离的多个阻挡层。 该方法还包括照射多个阻挡层中的至少一个，使得多个储存器中的至少一个被破坏，从而触发治疗剂和标记物从装置释放。 通过目视检测将标记物释放到解剖结构中，验证了治疗剂释放到解剖结构中。

公开(公告)号：US20130116782A1

公开(公告)日：2013-05-09

申请号：US13606517

申请日：2012-09-07

申请人： Kenneth N. HORNE ,  Sergio SALINAS ,  Geoffrey C. GURTNER ,  Michael H. ROSENTHAL ,  Christopher S. JONES ,  Joseph RIMSA

发明人： Kenneth N. HORNE ,  Sergio SALINAS ,  Geoffrey C. GURTNER ,  Michael H. ROSENTHAL ,  Christopher S. JONES ,  Joseph RIMSA

IPC分类号： A61F2/12

CPC分类号： A61H9/0057 ,  A61B90/02 ,  A61F2/12 ,  A61H2205/082

摘要： Apparatus and methods for nipple and breast formation are described where devices precondition or expand a target nipple tissue to reduce the pressure exerted by the skin on an eventual implant. Generally, the apparatus comprises a mold having a contact surface which is curved in conformance with a breast upon which the mold is positionable, the contact surface having an adhesive for securement upon the breast, and the mold defining a cavity along the contact surface which conforms to a size of a nipple to be formed upon the breast and where the cavity further comprises the adhesive for securement to the nipple. A breast enlargement device comprises a cup larger than the target breast and further defines an inner surface which adheres to the breast when contacted.

摘要翻译： 描述了用于乳头和乳房形成的装置和方法，其中装置预处理或扩大目标乳头组织，以减少最终植入时由皮肤施加的压力。 通常，该装置包括具有接触表面的模具，该接触表面与模具可定位在其上的乳房一致地弯曲，接触表面具有用于固定在乳房上的粘合剂，并且模具沿着接触表面限定空腔， 到乳房上形成的乳头的尺寸，并且其中腔还包括用于固定到乳头的粘合剂。 乳房放大装置包括比目标乳房大的杯子，并进一步限定了当接触时粘附到乳房的内表面。

公开(公告)号：US20120101575A1

公开(公告)日：2012-04-26

申请号：US13277464

申请日：2011-10-20

申请人： Kenneth N. HORNE ,  Michael H. ROSENTHAL ,  Geoffrey C. GURTNER ,  Christopher S. Jones ,  Sergio Salinas ,  Joseph Rimsa

发明人： Kenneth N. HORNE ,  Michael H. ROSENTHAL ,  Geoffrey C. GURTNER ,  Christopher S. Jones ,  Sergio Salinas ,  Joseph Rimsa

IPC分类号： A61F2/12 ,  A61B19/00

CPC分类号： A61F2/12 ,  A61B17/00 ,  A61B2017/00792 ,  A61B2017/00796 ,  A61B2017/00876 ,  A61F2002/526 ,  A61F2210/009 ,  A61H2205/082 ,  A61J13/00

摘要： Apparatus and methods for nipple and breast formation are described where devices precondition or expand a target nipple tissue to reduce the pressure exerted by the skin on an eventual implant. Generally, the apparatus comprises a mold having a contact surface which is curved in conformance with a breast upon which the mold is positionable, the contact surface having an adhesive for securement upon the breast, and the mold defining a cavity along the contact surface which conforms to a size of a nipple to be formed upon the breast and where the cavity further comprises the adhesive for securement to the nipple. A breast enlargement device comprises a cup larger than the target breast and further defines an inner surface which adheres to the breast when contacted.

摘要翻译： 描述了用于乳头和乳房形成的装置和方法，其中装置预处理或扩大目标乳头组织，以减少最终植入时由皮肤施加的压力。 通常，该装置包括具有接触表面的模具，该接触表面与模具可定位在其上的乳房一致地弯曲，接触表面具有用于固定在乳房上的粘合剂，并且模具沿着接触表面限定空腔， 到乳房上形成的乳头的尺寸，并且其中腔还包括用于固定到乳头的粘合剂。 乳房放大装置包括比目标乳房大的杯子，并进一步限定了当接触时粘附到乳房的内表面。