公开(公告)号：US12076570B2

公开(公告)日：2024-09-03

申请号：US17816536

申请日：2022-08-01

Applicant: NeuroSteer Inc.

Inventor： Nathan Intrator

IPC: A61N1/36 ,  A61B5/00 ,  A61B5/316 ,  A61N1/05 ,  A61N1/372 ,  A61B5/24

CPC classification number: A61N1/3727 ,  A61B5/316 ,  A61B5/4836 ,  A61B5/7282 ,  A61N1/0534 ,  A61B5/0006 ,  A61B5/2415 ,  A61B5/4848 ,  A61N1/36067 ,  A61N1/36075 ,  A61N1/36078 ,  A61N1/36092 ,  A61N1/36096

Abstract: Methods and systems for optimizing invasive and noninvasive brain stimulation are described herein. In a particular embodiment, methods and systems for a combinatorial, iterative approach to modify behavior are presented wherein deep brain stimulation (DBS) and other brain stimulation therapies are implemented in combination with monitoring the brain activity of an individual to optimize the effectiveness of the combinatorial approach to modify behavior. Methods described herein are iterative and systems described herein are utilized in iterative fashion. In a particular embodiment, modifying behavior provides a therapy for an individual in need thereof.

公开(公告)号：US20240198103A1

公开(公告)日：2024-06-20

申请号：US18591326

申请日：2024-02-29

Applicant: Realeve, LLC

Inventor： William Hsu ,  Ian Welsford ,  Mark Van Kerkwyk ,  Vimal Ganesan ,  Bruce Levin

IPC: A61N1/36 ,  A61N1/04 ,  A61N1/05 ,  A61N1/372 ,  A61N1/378

CPC classification number: A61N1/36075 ,  A61N1/0546 ,  A61N1/36146 ,  A61N1/37241 ,  A61N1/3787 ,  A61N1/0476 ,  A61N1/0526 ,  A61N1/36057 ,  A61N1/37205

Abstract: An implantable neurostimulator includes a lead comprising a plurality of electrodes at a distal end, and an implant body including electronics for controlling operation of the electrodes. An electrical connector establishes an electrical connection between the electronics and the electrodes. The implant body includes a first portion of the electrical connector, and the proximal end of the lead includes a second portion of the electrical connector. The first and second portions of the electrical connector are connectable to establish the electrical connection between the electronics and the electrodes. The lead is configured for initial implantation in the patient and the implant body is configured for subsequent implantation in the patient. The electrical connector is configured so that the connection of the first and second portions can be performed with the implant body and the lead positioned at a surgical site in the patient.

公开(公告)号：US11951311B2

公开(公告)日：2024-04-09

申请号：US17991359

申请日：2022-11-21

Applicant: Avent, Inc.

Inventor： Eric A. Schepis ,  David M. Page ,  Natalia Alexeeva ,  Lee C. Burnes

IPC: A61N1/36 ,  A61N1/05 ,  A61N1/365

CPC classification number: A61N1/36075 ,  A61N1/0509 ,  A61N1/0512 ,  A61N1/0521 ,  A61N1/0546 ,  A61N1/36071 ,  A61N1/36135 ,  A61N1/36139 ,  A61N1/3614 ,  A61N1/36142 ,  A61N1/36171 ,  A61N1/36175 ,  A61N1/365 ,  A61N1/36021

Abstract: The present disclosure is directed to a system and method for selectively and reversibly modulating targeted neural and non-neural tissue of a nervous system for the treatment of pain. An electrical stimulation is delivered to the treatment site that selectively and reversibly modulates the targeted neutral- and non-neural tissue of the nervous structure, inhibiting the perception of pain while preserving other sensory and motor function, and proprioception.

公开(公告)号：US11938320B2

公开(公告)日：2024-03-26

申请号：US17121545

申请日：2020-12-14

Applicant: Saluda Medical Pty Ltd

Inventor： John Louis Parker

IPC: A61N1/00 ,  A61N1/36

CPC classification number: A61N1/36062 ,  A61N1/36067 ,  A61N1/36139 ,  A61N1/36075 ,  A61N1/36185

Abstract: Estimating a nerve-to-electrode distance involves applying a stimulus from a stimulus electrode to a nerve. Neural measurements of at least one evoked compound action potential are obtained, and processed in order to estimate an originating state of stimulation exhibiting at least one characteristic defined by a single fibre size. A single fibre model is then applied to produce a measure of the nerve-to-electrode distance. Also provided for is estimation of a distribution of recruited fibres. Measurements of a compound action potential are obtained from sense electrodes spaced apart along a neural pathway. A conduction velocity of the compound action potential is determined from the latency between the measurements. From the conduction velocity a dominant recruited fibre diameter is determined. A rate of dispersion of the compound action potential between the sense electrodes is determined. From the rate of dispersion a distribution of diameters of the recruited fibre population is determined.

公开(公告)号：US11857791B2

公开(公告)日：2024-01-02

申请号：US16940557

申请日：2020-07-28

Applicant: NYXOAH SA

Inventor： Adi Mashiach ,  Itzik Mashiach

IPC: A61N1/36 ,  A61N1/05 ,  A61N1/375 ,  A61N1/378 ,  A61N2/00 ,  A61B5/00 ,  A61B5/11 ,  A61B5/113 ,  A61F5/56 ,  A61N1/372 ,  A61B5/389 ,  A61B5/08 ,  A61N2/02

CPC classification number: A61N1/3611 ,  A61B5/0031 ,  A61B5/08 ,  A61B5/11 ,  A61B5/113 ,  A61B5/389 ,  A61B5/4818 ,  A61B5/682 ,  A61F5/566 ,  A61N1/0514 ,  A61N1/0526 ,  A61N1/0553 ,  A61N1/3601 ,  A61N1/36003 ,  A61N1/3606 ,  A61N1/36057 ,  A61N1/36135 ,  A61N1/36139 ,  A61N1/36146 ,  A61N1/3756 ,  A61N1/3787 ,  A61N1/37223 ,  A61N1/37229 ,  A61N2/006 ,  H05K999/00 ,  H05K999/99 ,  A61B5/4519 ,  A61B5/6822 ,  A61B5/6833 ,  A61B5/6876 ,  A61B2560/0219 ,  A61B2562/164 ,  A61N1/36075 ,  A61N1/36117 ,  A61N2/02

Abstract: An implant unit configured for implantation into a body of a subject is provided. The implant unit may include a flexible carrier unit including a central portion and two elongated arms extending from the central portion, an antenna, located on the central portion, configured to receive a signal, at least one pair of electrodes arranged on a first elongated arm of the two elongated arms. The at least one pair of electrodes may be adapted to modulate a first nerve. The elongated arms of the flexible carrier may be configured to form an open ended curvature around a muscle with the nerve to be stimulated within an arc of the curvature.

公开(公告)号：US11826156B2

公开(公告)日：2023-11-28

申请号：US17510264

申请日：2021-10-25

Applicant: Saluda Medical Pty Ltd

Inventor： Dean Michael Karantonis ,  Peter Scott Vallack Single ,  Kai Huang

IPC: A61B5/377 ,  A61N1/36 ,  A61N1/372 ,  A61B5/24 ,  A61B5/00 ,  A61B5/05 ,  A61N1/378 ,  A61N1/18 ,  A61B5/291

CPC classification number: A61B5/377 ,  A61B5/05 ,  A61B5/24 ,  A61B5/291 ,  A61B5/686 ,  A61B5/7225 ,  A61N1/18 ,  A61N1/36 ,  A61N1/36067 ,  A61N1/36071 ,  A61N1/36075 ,  A61N1/3787 ,  A61N1/37264 ,  A61B2562/063

Abstract: A neural stimulus comprises at least three stimulus components, each comprising at least one of a temporal stimulus phase and a spatial stimulus pole. A first stimulus component delivers a first charge which is unequal to a third charge delivered by a third stimulus component, and the first charge and third charge are selected so as to give rise to reduced artefact at recording electrodes. In turn this may be exploited to independently control a correlation delay of a vector detector and an artefact vector to be non-parallel or orthogonal.

公开(公告)号：US11738203B2

公开(公告)日：2023-08-29

申请号：US17009635

申请日：2020-09-01

Applicant: EPIC Neuro, Inc.

Inventor： James William Phillips

IPC: A61N1/378 ,  A61N1/36 ,  A61N1/18 ,  A61N1/05

CPC classification number: A61N1/3787 ,  A61N1/0531 ,  A61N1/3606 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36071 ,  A61N1/36075 ,  A61N1/36103 ,  A61N1/36139 ,  A61N1/36171 ,  A61N1/0529 ,  A61N1/0534 ,  A61N1/36082

Abstract: A method and device is described, which provides electrical stimulation to the brain of a person, where the device comprises an external portion and at least one implantable portion. The external portion provides the energy source for stimulation to the implantable portions. The implantable portions provide at least two conductive paths through the skull and use the skull's high impedance to generate a current loop with the focus of stimulation lying in the current path.

公开(公告)号：US11697018B2

公开(公告)日：2023-07-11

申请号：US17101718

申请日：2020-11-23

Applicant: Modular Bionics Inc.

Inventor： Ian Loren Halpern ,  Mark William Merlo

IPC: A61N1/05 ,  A61N1/36 ,  A61B17/00 ,  A61N1/372 ,  A61B17/068 ,  A61B17/076 ,  A61B17/064

CPC classification number: A61N1/0529 ,  A61B17/00234 ,  A61N1/3605 ,  A61N1/36007 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36071 ,  A61N1/36075 ,  A61N1/36082 ,  A61N1/36085 ,  A61N1/36089 ,  A61N1/36096 ,  A61N1/36107 ,  A61N1/37282 ,  A61B17/068 ,  A61B17/076 ,  A61B2017/00075 ,  A61B2017/00345 ,  A61B2017/0641

Abstract: Devices and methods for manipulating devices such as micro-scale devices are provided. The devices can include a tether of various materials surrounded by a stiff body. The tether interfaces with microscale devices to draw them against the stiff body, holding the microscale devices in a locked position for insertion into or extraction out of tissue. The tensional hook and stiff body are configurable in a multitude of positions and geometries to provide increased engagement. Such configurations allow for a range of implantation and extraction surgical procedures for the device within research and clinical settings.

公开(公告)号：US20190239768A1

公开(公告)日：2019-08-08

申请号：US16311526

申请日：2017-06-23

Applicant: Saluda Medical Pty Ltd

Inventor： Dean Karantonis ,  Peter Scott Vallack Single ,  Kai Huang

IPC: A61B5/0484 ,  A61B5/0478 ,  A61B5/00

CPC classification number: A61B5/0484 ,  A61B5/04001 ,  A61B5/0478 ,  A61B5/05 ,  A61B5/686 ,  A61B5/7225 ,  A61B2562/063 ,  A61N1/18 ,  A61N1/36 ,  A61N1/36067 ,  A61N1/36071 ,  A61N1/36075 ,  A61N1/37264 ,  A61N1/3787

Abstract: A neural stimulus comprises at least three stimulus components, each comprising at least one of a temporal stimulus phase and a spatial stimulus pole. A first stimulus component delivers a first charge which is unequal to a third charge delivered by a third stimulus component, and the first charge and third charge are selected so as to give rise to reduced artefact at recording electrodes. In turn this may be exploited to independently control a correlation delay of a vector detector and an artefact vector to be non-parallel or orthogonal.

公开(公告)号：US20190217096A1

公开(公告)日：2019-07-18

申请号：US16128276

申请日：2018-09-11

Applicant: Nevro Corp.

Inventor： Jon Parker

IPC: A61N1/36 ,  A61N1/05 ,  A61N1/372

CPC classification number: A61N1/36071 ,  A61N1/0551 ,  A61N1/36075 ,  A61N1/36128 ,  A61N1/36132 ,  A61N1/36185 ,  A61N1/37247

Abstract: Devices for controlling spinal cord modulation for inhibiting pain, and associated systems and methods, including controllers for automated parameter selection are disclosed. A particular embodiment includes receiving a first input corresponding to a location of a signal delivery device implanted in a patient, establishing a positional relationship between the signal delivery device and an anatomical feature of the patient, receiving a second input corresponding to a medical indication of the patient, and, based at least in part on the positional relationship and the indication, automatically identifying a signal delivery parameter in accordance with which a pulsed electrical signal is delivered to the patient via the signal delivery device.