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18 条记录 (耗时 0.052 秒)

    3-modified leucomycin derivatives
    1.
    发明授权
    3-modified leucomycin derivatives 失效
    3修饰的leucomycin衍生物

    公开(公告)号：US06660718B1

    公开(公告)日：2003-12-09

    申请号：US09980113

    申请日：2001-11-30

    申请人： Ken-ichi Kurihara ,  Takeshi Furuuchi ,  Takuji Yoshida ,  Tomoaki Miura ,  Keiichi Ajito

    发明人： Ken-ichi Kurihara ,  Takeshi Furuuchi ,  Takuji Yoshida ,  Tomoaki Miura ,  Keiichi Ajito

    IPC分类号： C07H1708

    CPC分类号： C07H17/08

    摘要： A compound represented by the following general formula (I) or a salt thereof: wherein R&agr; represents a C1-C10 alkyl group, a C3-C10 alkenyl group, a C7-C15 aralkyl group, a quinolinylalkyl group, a quinolinylalkenyl group, a C2-C10 alkylcarbonyl group, a C7-C15 aralkylcarbonyl group, a C4-C7 cycloalkylcarbonyl group, benzoyl group, an imidazolylcarbonyl group and the like; R1 represents hydrogen atom, a C1-C10 alkyl group, or a C2-C10 alkylcarbonyl group; and R2 represents hydrogen atom, a C1-C10 alkyl group, or a C2-C10 alkylcarbonyl group, provided that the compound wherein R&agr; represents a C2-C10 alkylcarbonyl group and both of R1 and R2 represent a C1-C10 alkyl group is excluded.

    摘要翻译： 由以下通式（I）表示的化合物或其盐：其中R表示C1-C10烷基，C3-C10烯基，C7-C15芳烷基，喹啉基烷基，喹啉基烯基 C2-C10烷基羰基，C7-C15芳烷基羰基，C4-C7环烷基羰基，苯甲酰基，咪唑基羰基等; R 1表示氢原子，C 1 -C 10烷基或C 2 -C 10烷基羰基; 并且R 2表示氢原子，C 1 -C 10烷基或C 2 -C 10烷基羰基，条件是其中R 1表示C 2 -C 10烷基羰基并且R 1和R 2均为 2>表示不包括C1-C10烷基。

    Novel 15-membered cyclic azalide, novel 16-membered cyclic diazalide derivative, and process for producing these
    2.
    发明申请
    Novel 15-membered cyclic azalide, novel 16-membered cyclic diazalide derivative, and process for producing these 审中-公开
    新的15元环氮杂环丁烷，新的16元环二氮杂衍生物及其制备方法

    公开(公告)号：US20050209446A1

    公开(公告)日：2005-09-22

    申请号：US10504327

    申请日：2003-02-25

    申请人： Tomoaki Miura ,  Ken-ichi Kurihara ,  Takuji Yoshida ,  Keiichi Ajito

    发明人： Tomoaki Miura ,  Ken-ichi Kurihara ,  Takuji Yoshida ,  Keiichi Ajito

    IPC分类号： A61P31/04 ,  C07H17/08 ,  A61K31/7052

    CPC分类号： C07H17/08

    摘要： A compound represented by the general formula (I) or a salt thereof which has excellent antibacterial activity (R1 represents hydrogen atom or an alkylcarbonyl group, R2 represents hydrogen atom, oxygen atom, hydroxyl group, or an alkylcarbonyloxy group, for example, when R2 is hydrogen atom, R3 represents group (a) (each of R5 and R6 represents hydrogen atom or an alkyl group), R4 represents hydrogen atom or group (c) (each of R8 and R9 represents hydrogen atom or an alkylcarbonyl group), and Me represents methyl group).

    摘要翻译： 由通式（I）表示的化合物或其盐具有优异的抗菌活性（R 1表示氢原子或烷基羰基，R 2表示氢原子， 氧原子，羟基或烷基羰基氧基，例如当R 2是氢原子时，R 3表示基团（a）（R 5 R 3和R 6代表氢原子或烷基），R 4表示氢原子或基团（c）（R 8各自独立地选自氢， 和R 9表示氢原子或烷基羰基，Me表示甲基）。

    Azalide and azalactam derivatives and method for producing the same
    5.
    发明授权
    Azalide and azalactam derivatives and method for producing the same 失效
    氮杂吲哚衍生物及其制备方法

    公开(公告)号：US07365174B2

    公开(公告)日：2008-04-29

    申请号：US10569063

    申请日：2004-08-20

    申请人： Tomoaki Miura ,  Kenichi Kanemoto ,  Satomi Natsume ,  Naoto Ohkura ,  Yumiko Fujihira ,  Takashi Watanabe ,  Hideki Fushimi ,  Kunio Atsumi ,  Keiichi Ajito

    发明人： Tomoaki Miura ,  Kenichi Kanemoto ,  Satomi Natsume ,  Naoto Ohkura ,  Yumiko Fujihira ,  Takashi Watanabe ,  Hideki Fushimi ,  Kunio Atsumi ,  Keiichi Ajito

    IPC分类号： C07H17/08

    CPC分类号： A61K31/7052 ,  C07H15/04 ,  C07H17/00

    摘要： Compounds represented by the general formula (1) or pharmaceutically acceptable salts thereof, effective in the prevention and/or treatment of infections with microbes: (1) (a) wherein R1 is hydrogen or straight-chain C1-6 alkylcarbonyl; R2 is hydrogen or C1-6 alkylcarbonyl; R3 is hydrogen, C1-6 alkyl, C1-6 alkylcarbonyl, C1-6 alkenyl, C2-6 alkenylcarbonyl, C2-6 alkynyl, or an Ar—B— group (wherein Ar is aryl or a heterocyclic group; and B is C1-6 alkyl, C1-6 alkylcarbonyl, C2-6 alkenyl, C2-6 alkenylcarbonyl, or C2-6 alkynyl); R5, R6, R7 and R8 are each hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, or an Ar—B′— group (wherein B′ is C1-6 alkyl, C2-6 alkenyl, or C2-6 alkynyl); X is oxygen or —NR4— (wherein R4 is hydrogen, C1-6 alkyl or C1-6 alkyl which may be substituted with Ar); and R4′ is hydrogen or a group represented by the general formula (a) (wherein R3″ and R4″ are each hydrogen or straight-chain or branched C1-6 alkylcarbonyl)

    摘要翻译： 由通式（1）表示的化合物或其药学上可接受的盐在预防和/或治疗微生物感染方面有效：（1）（a）其中R 1是氢或直链 C 1-6烷基羰基; R 2是氢或C 1-6烷基羰基; R 3是氢，C 1-6烷基，C 1-6 - 烷基羰基，C 1-6 - 烯基 ，C 2-6链烯基羰基，C 2-6炔基或Ar-B基（其中Ar为芳基或杂环基; B为C

    Nozel azalide and azalactam derivatives and method for producing the same
    6.
    发明申请
    Nozel azalide and azalactam derivatives and method for producing the same 失效
    诺贝尔氮杂和吖内酰胺衍生物及其制备方法

    公开(公告)号：US20070042974A1

    公开(公告)日：2007-02-22

    申请号：US10569063

    申请日：2004-08-20

    申请人： Tomoaki Miura ,  Kenichi Kanemoto ,  Satomi Natsume ,  Naoto Ohkura ,  Yumiko Fujihira ,  Takashi Watanabe ,  Hideki Fushimi ,  Kunio Atsumi ,  Keiichi Ajito

    发明人： Tomoaki Miura ,  Kenichi Kanemoto ,  Satomi Natsume ,  Naoto Ohkura ,  Yumiko Fujihira ,  Takashi Watanabe ,  Hideki Fushimi ,  Kunio Atsumi ,  Keiichi Ajito

    IPC分类号： A61K31/7052 ,  C07H17/08

    CPC分类号： A61K31/7052 ,  C07H15/04 ,  C07H17/00

    摘要： A compound represented by the following general formula (1) or a pharmaceutically acceptable salt thereof, which is useful for a prophylactic and/or therapeutic treatment of a microbial infectious disease. [R1 is hydrogen atom, or a linear C1-6 alkylcarbonyl group; R2 is hydrogen atom, or a C1-6 alkylcarbonyl group; R3 is hydrogen atom, a C1-6 alkyl group, a C1-6 alkylcarbonyl group, a C1-6 alkenyl group, a C2-6 alkenylcarbonyl group, a C2-6 alkynyl group, or an Ar—B— group (Ar represents an aryl group, or a heterocyclic group, and B is a C1-6 alkyl group, a C1-6 alkylcarbonyl group, a C2-6 alkenyl group, a C2-6 alkenylcarbonyl group, or a C2-6 alkynyl group); R5, R6, R7, and R8 represent hydrogen atom, a C1-6 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, or an Ar—B′— group (B′ is a C1-6 alkyl group, a C2-6 alkenyl group, or a C2-6 alkynyl group); X is oxygen atom, or an —NR4— group (R4 is hydrogen atom, a C1-6 alkyl group, or a C1-6 alkyl group which may be substituted with an Ar group); and R4′ is hydrogen atom, or a group represented by the aforementioned formula (a) (R3″ and R4″ represent hydrogen atom, or a linear or branched C1-6 alkylcarbonyl group)]

    摘要翻译： 由以下通式（1）表示的化合物或其药学上可接受的盐，其可用于预防和/或治疗微生物感染性疾病。 R 1是氢原子或直链C 1-6烷基羰基; R 2是氢原子或C 1-6烷基羰基; R 3是氢原子，C 1-6烷基，C 1-6烷基羰基，C 1-6烯基，C 2-6烯基羰基，C 2-6炔基或 Ar-B-基（Ar表示芳基或杂环基，B为C1-6烷基，C1-6烷基羰基，C2-6烯基，C2-6链烯基羰基或 C 2-6炔基）; R 5，R 6，R 7和R 8表示氢原子，C 1-6烷基 ，C2-6烯基，C2-6炔基或Ar-B'-基（B'是C1-6烷基，C2-6链烯基或C2-6炔基）; X是氧原子或-NR 4 - 基团（R 4）是氢原子，C 1-6烷基或可以是C 1-6烷基的C 1-6烷基 被Ar基团取代）; 和R 4'是氢原子，或由上述式（a）表示的基团（R 3'和R 4“ 代表氢原子，或直链或支链C 1-6烷基羰基）]