公开(公告)号：US07428435B2

公开(公告)日：2008-09-23

申请号：US10743947

申请日：2003-12-24

申请人： Kenji Fukuta ,  Kanji Sakata

发明人： Kenji Fukuta ,  Kanji Sakata

IPC分类号： A61N1/30

CPC分类号： A61N1/30

摘要： A medical instrument for transdermally administering a medicine, in which an ionic medicine or an ionic medicine-containing substance is sealed in a bag made of an ion-exchange membrane. The medical instrument for transdermally administering the medicine is favorably used for executing the iontophoresis. By using this medical instrument, an iontophoresis device is realized in a simple structure, inexpensively and in a small size, which is suited for being carried yet making it easy to exchange the ionic medicine.

摘要翻译： 一种用于经皮给药的医疗器械，其中将离子药物或含离子药物的物质密封在由离子交换膜制成的袋中。 用于透皮给药的医疗器械有利地用于执行离子电渗疗法。 通过使用该医疗器械，离子电渗疗法装置以简单的结构实现，成本低廉，适用于携带而易于交换离子药物。

公开(公告)号：US20060198879A1

公开(公告)日：2006-09-07

申请号：US10547920

申请日：2004-03-09

申请人： Kenji Fukuta ,  Kanji Sakata

发明人： Kenji Fukuta ,  Kanji Sakata

IPC分类号： A61F13/02

CPC分类号： A61K9/7084

摘要： The present invention discloses a patch for use in administration of an ionic medicine into a living body by infiltration of the ionic medicine into the living body through the living body surface without voltage application, characterized in that the patch comprises an ion-exchange membrane having a surface roughness (Rz) of 7 μm or less at its part to be brought into contact with the living body surface and an ionic medicine impregnated into the ion-exchange membrane.

公开(公告)号：US07734339B2

公开(公告)日：2010-06-08

申请号：US10536398

申请日：2003-11-26

申请人： Kenji Fukuta ,  Kanji Sakata

发明人： Kenji Fukuta ,  Kanji Sakata

IPC分类号： A61N1/30

CPC分类号： A61N1/0444 ,  A61N1/0436 ,  A61N1/0448 ,  A61N1/30

摘要： An iontophoresis device comprising (A) a working electrode assembly having a working electrode, a medicine-containing portion and an ion-exchange membrane, (B) a counter electrode assembly having an electrode which opposes the working electrode, and (C) a power source unit electrically connected to the working electrode assembly and to the counter electrode assembly, enabling an ionic medicine contained in the medicine containing portion to be permeated into a living body by the electrophoresis through the ion-exchange membrane, wherein the ion-exchange membrane has a structure in which voids of a porous film are filled with an ion-exchange resin. The iontophoresis device using the above ion-exchange membrane makes it possible to administer the medicine in amounts larger than those accomplished by using the conventional devices.

摘要翻译： 1.一种离子电渗疗法装置，其特征在于，包括：（A）具有工作电极，药物含有部分和离子交换膜的工作电极组件，（B）具有与工作电极相对的电极的对电极组件，（C） 源极单元，电连接到工作电极组件和对电极组件，使得包含在药物容纳部分中的离子药物能够通过离子交换膜通过电泳渗透到生物体中，其中离子交换膜具有 用离子交换树脂填充多孔膜的空隙的结构。 使用上述离子交换膜的离子电渗装置使得可以以比通过使用常规装置所达到的量更大的量来给药。

公开(公告)号：US07479132B2

公开(公告)日：2009-01-20

申请号：US10547920

申请日：2004-03-09

申请人： Kenji Fukuta ,  Kanji Sakata

发明人： Kenji Fukuta ,  Kanji Sakata

IPC分类号： A61M31/00 ,  A61N1/30 ,  A61K9/00 ,  A61F13/00

CPC分类号： A61K9/7084

摘要： The present invention discloses a patch for use in administration of an ionic medicine into a living body by infiltration of the ionic medicine into the living body through the living body surface without voltage application, characterized in that the patch comprises an ion-exchange membrane having a surface roughness (Rz) of 7 μm or less at its part to be brought into contact with the living body surface and an ionic medicine impregnated into the ion-exchange membrane.

摘要翻译： 本发明公开了一种用于通过在不施加电压的情况下通过生物体表面将离子药物渗透到生物体中而将离子药物施用于生物体的贴剂，其特征在于，所述贴剂包含离子交换膜，其具有 表面粗糙度（Rz）在其与生物体表面接触的部分为7μm或更小，以及浸渍到离子交换膜中的离子药物。

公开(公告)号：US20060241548A1

公开(公告)日：2006-10-26

申请号：US10536398

申请日：2003-11-26

申请人： Kenji Fukuta ,  Kanji Sakata

发明人： Kenji Fukuta ,  Kanji Sakata

IPC分类号： A61N1/30

CPC分类号： A61N1/0444 ,  A61N1/0436 ,  A61N1/0448 ,  A61N1/30

摘要： An iontophoresis device comprising (A) a working electrode assembly having a working electrode, a medicine-containing portion and an ion-exchange membrane, (B) a counter electrode assembly having an electrode which opposes the working electrode, and (C) a power source unit electrically connected to the working electrode assembly and to the counter electrode assembly, enabling an ionic medicine contained in the medicine containing portion to be permeated into a living body by the electrophoresis through the ion-exchange membrane, wherein the ion-exchange membrane has a structure in which voids of a porous film are filled with an ion-exchange resin. The iontophoresis device using the above ion-exchange membrane makes it possible to administer the medicine in amounts larger than those accomplished by using the conventional devices.

摘要翻译： 1.一种离子电渗疗法装置，其特征在于，包括：（A）具有工作电极，药物含有部分和离子交换膜的工作电极组件，（B）具有与工作电极相对的电极的对电极组件，（C） 源极单元，电连接到工作电极组件和对电极组件，使得包含在药物容纳部分中的离子药物能够通过离子交换膜通过电泳渗透到生物体中，其中离子交换膜具有 用离子交换树脂填充多孔膜的空隙的结构。 使用上述离子交换膜的离子电渗装置使得可以以比通过使用常规装置所达到的量更大的量来给药。

公开(公告)号：US20090124957A1

公开(公告)日：2009-05-14

申请号：US11597610

申请日：2005-05-25

申请人： Kenji Fukuta ,  Kanji Sakata

发明人： Kenji Fukuta ,  Kanji Sakata

IPC分类号： A61N1/30

CPC分类号： B01J47/12 ,  A61N1/30 ,  B01D61/44 ,  B01D67/0006 ,  B01D2323/30 ,  B01D2323/36 ,  C08J5/2243 ,  C08J2325/18

摘要： A method of producing an ion-exchange membrane for iontophoresis by preparing a polymerizable composition containing monomer components and non-polymerizable components which are compatible with the monomer components but do not copolymerize therewith; forming the polymerizable composition into a membrane form; polymerizing the polymerizable composition in the obtained membrane form to thereby form a membrane of a structure in which the non-polymerizable components are dispersed in the polymer having a crosslinked structure; removing the non-polymerizable components from the obtained membrane; and, as required, introducing ion-exchange groups into the polymer. The ion-exchange membrane obtained by the above method is applied to an iontophoresis device. When an ionic medicine contained in a medicine-containing portion of the device is permeated into a living body by the electrophoresis through the ion-exchange membrane, not only ionic medicines having small formula weights but also medicinal ions of formula weights of about 500 to about 1,000 can be efficiently administered into the living body.

摘要翻译： 一种制备用于离子电渗疗法的离子交换膜的方法，该方法是制备含单体组分和与该单体成分相容但不与其共聚的非聚合性组分的聚合性组合物; 将可聚合组合物形成膜形式; 聚合所获得的膜形式的可聚合组合物，从而形成其中不可聚合组分分散在具有交联结构的聚合物中的结构的膜; 从所得膜除去不可聚合组分; 并根据需要将离子交换基团引入聚合物中。 将通过上述方法获得的离子交换膜应用于离子电渗装置。 当通过离子交换膜的电泳将包含在该装置的含药部分中的离子药物渗透到生物体中时，不仅具有小配方重量的离子药物，而且还具有约500至约 可以将1,000个有效地施用于生物体。

公开(公告)号：US20080305251A1

公开(公告)日：2008-12-11

申请号：US12153864

申请日：2008-05-27

申请人： Kenji Fukuta ,  Kazuyuki Sadasue ,  Takenori Isomura ,  Kanji Sakata

发明人： Kenji Fukuta ,  Kazuyuki Sadasue ,  Takenori Isomura ,  Kanji Sakata

IPC分类号： B05D5/12

CPC分类号： H01M8/1004 ,  H01M4/921 ,  H01M4/925 ,  H01M8/1011 ,  H01M8/1051 ,  H01M8/1053 ,  H01M8/1072 ,  H01M2300/0082 ,  Y02E60/523 ,  Y02P70/56

摘要： A laminate consisting of an ion exchange membrane layer comprising a porous film reinforcement and a crosslinked ion exchange resin and a conductive layer formed on at least one side of the ion exchange membrane layer and comprising conductive inorganic particles and a crosslinked ion exchange resin, whereinthe ion exchange membrane layer and the conductive layer are integrated with each other by the above ion exchange resins constituting these layers.This laminate is excellent in dimensional stability, heat resistance and methanol impermeability, which makes it suitable for use in electrochemical devices such as a direct methanol type fuel cell as a membrane-electrode assembly, has high bonding properties between the electrode layer and the ion exchange membrane layer of the membrane-electrode assembly, and provides a fuel cell whose output is not reduced by long-term use.

摘要翻译： 由包含多孔膜增强剂和交联离子交换树脂的离子交换膜层和在所述离子交换膜层的至少一侧上形成的导电性无机颗粒和交联离子交换树脂构成的导电层构成的层叠体，其中， 离子交换膜层和导电层通过构成这些层的上述离子交换树脂彼此一体化。 该层叠体的尺寸稳定性，耐热性和甲醇不渗透性优异，适用于电化学装置，例如直接甲醇型燃料电池作为膜 - 电极组件，在电极层和离子交换之间具有高的结合性 膜电极组件的膜层，并且提供其长期使用不会减少其输出的燃料电池。

公开(公告)号：US07272439B2

公开(公告)日：2007-09-18

申请号：US11253749

申请日：2005-10-20

申请人： Masumi Nagashima ,  Kenji Fukuta ,  Kanji Sakata

发明人： Masumi Nagashima ,  Kenji Fukuta ,  Kanji Sakata

IPC分类号： A61N1/30

CPC分类号： A61N1/0444 ,  A61N1/044 ,  A61N1/0448

摘要： A working electrode assembly for iontophoresis having a working electrode, a medicine-containing portion containing an ionic medicine, and an ion-exchange membrane arranged between the working electrode and the medicine-containing portion, wherein said ion-exchange membrane has both the anion-exchange groups and the cation-exchange groups, and between these anion-exchange groups and cation-exchange groups, the ion-exchange groups of the one side are contained in an excess amount compared to the other ion-exchange groups. The working electrode assembly effectively prevents the contact between the medicine and the working electrode and, at the same time, accomplishes a high efficiency for administering the medicine.

摘要翻译： 一种用于离子电渗疗法的工作电极组件，其具有工作电极，含有离子药物的药物含有部分和布置在所述工作电极和药物含有部分之间的离子交换膜，其中所述离子交换膜具有阴离子交换膜， 交换基团和阳离子交换基团，并且在这些阴离子交换基团和阳离子交换基团之间，与其它离子交换基团相比，一侧的离子交换基团被包含过量。 工作电极组件有效地防止了药物与工作电极之间的接触，并且同时实现了高效率地投药。

公开(公告)号：US20060089591A1

公开(公告)日：2006-04-27

申请号：US11253749

申请日：2005-10-20

申请人： Masumi Nagashima ,  Kenji Fukuta ,  Kanji Sakata

发明人： Masumi Nagashima ,  Kenji Fukuta ,  Kanji Sakata

IPC分类号： A61N1/30

CPC分类号： A61N1/0444 ,  A61N1/044 ,  A61N1/0448

摘要： A working electrode assembly for iontophoresis having a working electrode, a medicine-containing portion containing an ionic medicine, and an ion-exchange membrane arranged between the working electrode and the medicine-containing portion, wherein said ion-exchange membrane has both the anion-exchange groups and the cation-exchange groups, and between these anion-exchange groups and cation-exchange groups, the ion-exchange groups of the one side are contained in an excess amount compared to the other ion-exchange groups. The working electrode assembly effectively prevents the contact between the medicine and the working electrode and, at the same time, accomplishes a high efficiency for administering the medicine.

摘要翻译： 一种用于离子电渗疗法的工作电极组件，其具有工作电极，含有离子药物的药物含有部分和布置在所述工作电极和药物含有部分之间的离子交换膜，其中所述离子交换膜具有阴离子交换膜， 交换基团和阳离子交换基团，并且在这些阴离子交换基团和阳离子交换基团之间，与其它离子交换基团相比，一侧的离子交换基团被包含过量。 工作电极组件有效地防止了药物与工作电极之间的接触，并且同时实现了高效率地投药。

公开(公告)号：US20100104920A1

公开(公告)日：2010-04-29

申请号：US12532523

申请日：2008-03-27

申请人： Hitoshi Matsuoka ,  Kenji Fukuta ,  Kanji Sakata

发明人： Hitoshi Matsuoka ,  Kenji Fukuta ,  Kanji Sakata

IPC分类号： H01M8/10

CPC分类号： H01M8/1072 ,  H01B1/122 ,  H01M8/0289 ,  H01M8/1009 ,  H01M8/1025 ,  H01M8/1044 ,  H01M8/1062 ,  H01M8/1067 ,  Y02P70/56

摘要： The present invention discloses a membrane for direct liquid fuel cell comprising a porous film and a crosslinked hydrocarbon-based anion exchange resin filled in the pores of the porous film, in which the amino exchange resin has a quaternary ammonium group as an anion exchange group, wherein the membrane is characterized by having a membrane thickness of 5 to 60 μm, a membrane resistance as measured in a wet condition of 40° C. by an alternating impedance method, of 0.005 to 1.2 Ω·cm2, and a methanol permeability at 25° C. of 30 to 800 g·m−2·hr−1.

摘要翻译： 本发明公开了一种用于直接液体燃料电池的膜，其包含多孔膜和填充在多孔膜的孔中的交联的烃类阴离子交换树脂，其中氨基交换树脂具有季铵基作为阴离子交换基团， 其特征在于膜厚为5〜60μm，通过交流阻抗法在40℃的湿度条件下测定的膜电阻为0.005〜1.2Ωg·cm 2，甲醇渗透性为 25℃，30〜800g·m-2·hr-1。