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14 条记录 (耗时 0.037 秒)

    Sterol derivative
    1.
    发明授权
    Sterol derivative 有权
    甾醇衍生物

    公开(公告)号：US08952003B2

    公开(公告)日：2015-02-10

    申请号：US13386542

    申请日：2010-07-22

    申请人： Kenji Uchida ,  Tsutomu Agatsuma ,  Kazuhiro Hibino ,  Setsuya Sasho ,  Kyoichiro Iida ,  Hideyuki Onodera

    发明人： Kenji Uchida ,  Tsutomu Agatsuma ,  Kazuhiro Hibino ,  Setsuya Sasho ,  Kyoichiro Iida ,  Hideyuki Onodera

    IPC分类号： A61K31/55 ,  A61K31/585 ,  C07J73/00

    CPC分类号： C07J73/003 ,  A61K31/585 ,  C07J9/00 ,  C07J73/008 ,  C07J75/005

    摘要： The present invention provides a sterol derivative or a pharmaceutically acceptable salt thereof having an activity to promote proliferation of neural stem cells. Namely, the present invention provides a sterol derivative represented by the general formula (I) (wherein Y represents optionally substituted lower alkyl or the like; Xa and Xb are the same or different, and represent a bond or the like; R1, R2, R3, R4, R7 and R8 are the same or different, and represent a hydrogen atom or the like; R5 and R6 are the same or different, and represent a hydrogen atom or the like; R9 represents a hydrogen atom or the like; R10 and R11 together represent a bond or the like; and R12 represents a hydrogen atom or the like) or a pharmaceutically acceptable salt thereof.

    摘要翻译： 本发明提供具有促进神经干细胞增殖的活性的甾醇衍生物或其药学上可接受的盐。 即，本发明提供由通式（I）表示的固醇衍生物（其中Y表示任选取代的低级烷基等; Xa和Xb相同或不同，表示键或类似物; R1，R2， R3，R4，R7和R8相同或不同，表示氢原子等; R5和R6相同或不同，表示氢原子等; R9表示氢原子等; R10 和R 11一起表示键等; R 12表示氢原子等）或其药学上可接受的盐。

    Pyrimidodiazepinone derivative
    3.
    发明授权
    Pyrimidodiazepinone derivative 有权
    嘧啶二氮杂酮衍生物

    公开(公告)号：US07998954B2

    公开(公告)日：2011-08-16

    申请号：US12602312

    申请日：2008-06-02

    申请人： Nobumasa Otsubo ,  Yukihito Tsukumo ,  Kenji Uchida ,  Kyoichiro Iida ,  Hitoshi Arai ,  Shuko Okazaki ,  Takamichi Imaizumi

    发明人： Nobumasa Otsubo ,  Yukihito Tsukumo ,  Kenji Uchida ,  Kyoichiro Iida ,  Hitoshi Arai ,  Shuko Okazaki ,  Takamichi Imaizumi

    IPC分类号： C07D487/14 ,  A61K31/551 ,  A61P17/00 ,  A61P29/00

    CPC分类号： C07D487/14

    摘要： The invention provides a pyrimidodiazepinone derivative represented by the general formula (I) [wherein n represents 1 or 2, Z represents a hydrogen atom or the like, R1 and R2 may be the same or different, and each represents a hydrogen atom or the like, A represents a bond, (CH2)m (wherein m represents an integer of 1 to 4), optionally substituted phenylene, optionally substituted pyridinediyl, or C═O, R3 represents a hydrogen atom, optionally substituted lower alkyl, or the like, and R4 represents a hydrogen atom or the like], or a pharmaceutically acceptable salt thereof or the like.

    摘要翻译： 本发明提供由通式（I）表示的嘧啶并二氮杂酮衍生物[其中n表示1或2，Z表示氢原子等，R 1和R 2可以相同或不同，表示氢原子等 ，A表示键，（CH 2）m（其中m表示1至4的整数），任选取代的亚苯基，任选取代的吡啶二基或C = O，R 3表示氢原子，任选取代的低级烷基等， R 4表示氢原子等]或其药学上可接受的盐等。

    PYRIMIDODIAZEPINONE COMPOUND
    5.
    发明申请
    PYRIMIDODIAZEPINONE COMPOUND 有权
    吡咯烷酮锌化合物

    公开(公告)号：US20140171422A1

    公开(公告)日：2014-06-19

    申请号：US14116702

    申请日：2012-05-10

    申请人： Nobumasa Otsubo ,  Shuko Okazaki ,  Yukihito Tsukumo ,  Kyoichiro Iida ,  Masayoshi Nakoji

    发明人： Nobumasa Otsubo ,  Shuko Okazaki ,  Yukihito Tsukumo ,  Kyoichiro Iida ,  Masayoshi Nakoji

    IPC分类号： C07D487/14 ,  C07D495/04 ,  C07D471/04

    CPC分类号： C07D487/14 ,  A61K31/5517 ,  C07D471/04 ,  C07D495/04 ,  C07D519/00

    摘要： Provided are a compound represented by general formula (I), or the pharmaceutically acceptable salt thereof, (wherein Ra represents a hydrogen atom or the like, R1 and R2 may be the same or different, and each represents a hydrogen atom, optionally substituted lower alkyl or cycloalkyl, or R1 and R2 are combined together with the adjacent nitrogen atom thereto to form nitrogen-containing heterocyclic group, and Z represents a bicyclic heterocyclic group in which optionally substituted two six-membered rings are fused to each other, or the like) and the like.

    摘要翻译： 提供由通式（I）表示的化合物或其药学上可接受的盐，其中R a表示氢原子等，R 1和R 2可以相同或不同，各自表示氢原子，任选取代的低级 烷基或环烷基，或R1和R2与相邻的氮原子一起形成含氮杂环基，Z表示任选取代的两个六元环彼此稠合的双环杂环基等 ）等。

    Preventive and/or therapeutic drugs for asthma
    6.
    发明申请
    Preventive and/or therapeutic drugs for asthma 审中-公开
    用于哮喘的预防和/或治疗药物

    公开(公告)号：US20060239999A1

    公开(公告)日：2006-10-26

    申请号：US10525326

    申请日：2003-08-22

    申请人： Mayumi Saki ,  Hiromi Nonaka ,  Hiromasa Miyaji ,  Naoko Hiura ,  Haruhiko Manabe ,  Tsotomu Matsumura ,  Hitoshi Arai ,  Katsutoshi Sasaki ,  Cjoei Kobatake ,  Kyoichiro Iida ,  Takeshi Kuboyama

    发明人： Mayumi Saki ,  Hiromi Nonaka ,  Hiromasa Miyaji ,  Naoko Hiura ,  Haruhiko Manabe ,  Tsotomu Matsumura ,  Hitoshi Arai ,  Katsutoshi Sasaki ,  Cjoei Kobatake ,  Kyoichiro Iida ,  Takeshi Kuboyama

    IPC分类号： A61K48/00 ,  A61K39/395 ,  A61K31/55

    CPC分类号： A61K31/519 ,  A61K31/55 ,  A61K31/7088 ,  C07D403/06

    摘要： The present invention provides an agent for prevention and/or treatment of asthma comprising a substance capable of suppressing the function involved in signal transduction of GPR4 as an active ingredient. It also provides an agent for prevention and/or treatment of asthma which comprises a nitrogen-containing tricyclic compound represented by the formula (I) or a quaternary ammonium salt thereof, or a pharmaceutically acceptable salt thereof; [wherein R1 represents a substituted or unsubstituted lower alkyl, or the like; R2 represents hydrogen, a substituted or unsubstituted lower alkyl, or the like; R3 and R4 are the same or different and each represents hydrogen, lower alkyl, or the like; n represents 0 or 1; X represents —(CH2)2—, or the like; and Y represents the formula (II) (wherein W represents CH or a nitrogen atom; Z1 and Z2 are the same or different and each represents hydrogen, a substituted or unsubstituted lower alkyl, or the like; and Z3 represents hydrogen, a substituted or unsubstituted lower alkyl, or the like)] as an active ingredient.

    摘要翻译： 本发明提供了用于预防和/或治疗哮喘的药剂，其包含能够抑制作为活性成分的GPR4的信号转导所涉及的功能的物质。 它还提供了一种预防和/或治疗哮喘的药剂，其包含由式（I）表示的含氮三环化合物或其季铵盐或其药学上可接受的盐; [其中R 1表示取代或未取代的低级烷基等; R 2表示氢，取代或未取代的低级烷基等; R 3和R 4相同或不同，各自表示氢，低级烷基等; n表示0或1; X表示 - （CH 2 2）2 - 等; Y表示式（II）（其中W表示CH或氮原子; Z 1和Z 2相同或不同，各自表示氢，取代或 未取代的低级烷基等; Z 3表示氢，取代或未取代的低级烷基等）作为活性成分。

    [1,2,4] Triazolo[1,5-c]pyrimidine derivatives
    7.
    发明申请
    [1,2,4] Triazolo[1,5-c]pyrimidine derivatives 审中-公开
    [1,2,4]三唑并[1,5-c]嘧啶衍生物

    公开(公告)号：US20060058320A1

    公开(公告)日：2006-03-16

    申请号：US10528452

    申请日：2003-09-24

    申请人： Kyoichiro Iida ,  Takamasa Sugita ,  Shizuo Shiozaki ,  Tomoyuki Kanda ,  Yoshihisa Kuwana ,  Junichi Shimada

    发明人： Kyoichiro Iida ,  Takamasa Sugita ,  Shizuo Shiozaki ,  Tomoyuki Kanda ,  Yoshihisa Kuwana ,  Junichi Shimada

    IPC分类号： A61K31/519 ,  C07D487/04

    CPC分类号： C07D487/04

    摘要： The present invention provides [1,2,4]triazolo[1,5-c]pyrimidine derivatives or pharmaceutically acceptable salts thereof which have adenosine A2A receptor antagonism and are useful for treating and/or preventing a disease induced by hyperactivity of an adenosine A2A receptor, the derivatives being represented by formula (I): (wherein R1 represents substituted or unsubstituted aryl or a substituted or unsubstituted aromatic heterocyclic group; R2 represents a hydrogen atom, halogen, lower alkyl, lower alkanoyl, aroyl, substituted or unsubstituted aryl, or a substituted or unsubstituted aromatic heterocyclic group; R3 represents lower alkyl, lower cycloalkyl, substituted or unsubstituted lower alkanoyl, substituted or unsubstituted aryl, or a substituted or unsubstituted aromatic heterocyclic group; and Q represents a hydrogen atom or 3,4-dimethoxybenzyl).

    摘要翻译： 本发明提供具有腺苷A 2A 2受体拮抗作用的[1,2,4]三唑并[1,5-c]嘧啶衍生物或其药学上可接受的盐，可用于治疗和/或预防 由腺苷A 2A受体的多动症引起的疾病，该衍生物由式（I