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公开(公告)号:US08952003B2
公开(公告)日:2015-02-10
申请号:US13386542
申请日:2010-07-22
申请人: Kenji Uchida , Tsutomu Agatsuma , Kazuhiro Hibino , Setsuya Sasho , Kyoichiro Iida , Hideyuki Onodera
发明人: Kenji Uchida , Tsutomu Agatsuma , Kazuhiro Hibino , Setsuya Sasho , Kyoichiro Iida , Hideyuki Onodera
IPC分类号: A61K31/55 , A61K31/585 , C07J73/00
CPC分类号: C07J73/003 , A61K31/585 , C07J9/00 , C07J73/008 , C07J75/005
摘要: The present invention provides a sterol derivative or a pharmaceutically acceptable salt thereof having an activity to promote proliferation of neural stem cells. Namely, the present invention provides a sterol derivative represented by the general formula (I) (wherein Y represents optionally substituted lower alkyl or the like; Xa and Xb are the same or different, and represent a bond or the like; R1, R2, R3, R4, R7 and R8 are the same or different, and represent a hydrogen atom or the like; R5 and R6 are the same or different, and represent a hydrogen atom or the like; R9 represents a hydrogen atom or the like; R10 and R11 together represent a bond or the like; and R12 represents a hydrogen atom or the like) or a pharmaceutically acceptable salt thereof.
摘要翻译: 本发明提供具有促进神经干细胞增殖的活性的甾醇衍生物或其药学上可接受的盐。 即,本发明提供由通式(I)表示的固醇衍生物(其中Y表示任选取代的低级烷基等; Xa和Xb相同或不同,表示键或类似物; R1,R2, R3,R4,R7和R8相同或不同,表示氢原子等; R5和R6相同或不同,表示氢原子等; R9表示氢原子等; R10 和R 11一起表示键等; R 12表示氢原子等)或其药学上可接受的盐。
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公开(公告)号:US20110020931A1
公开(公告)日:2011-01-27
申请号:US12864923
申请日:2009-01-29
申请人: Hideyuki Onodera , Michio Ichimura , Kouji Baba , Tsutomu Agatsuma , Setsuya Sasho , Makoto Suzuki , Susumu Iwamoto , Shingo Kakita
发明人: Hideyuki Onodera , Michio Ichimura , Kouji Baba , Tsutomu Agatsuma , Setsuya Sasho , Makoto Suzuki , Susumu Iwamoto , Shingo Kakita
IPC分类号: C12N5/02 , C07J71/00 , C07D491/22 , C07D491/18 , C07D311/78 , C07C69/95
CPC分类号: C07J73/003 , A61K38/00 , C07D487/22 , C07D491/22 , C07D519/00 , C07J9/00 , C07J71/0005 , C07J71/001 , C12N5/0619 , C12N5/0623 , C12N2501/999 , C12P7/62 , C12P17/182 , C12P17/188 , C12P33/00 , C12P33/20 , C12R1/80
摘要: A proliferation promoting agent for neural stem cells, which comprises a compound produced by Penicillium sp. CND1007 (FERM BP-10917) or a pharmaceutically acceptable salt thereof, as an active ingredient; a novel compound produced by Penicillium sp. CND 1007 or a pharmaceutically acceptable salt thereof; a method for producing neural stem cells, which comprises culturing a neural stem cells to proliferate the neural stem cells in a presence of the compound produced by Penicillium sp. CND 1007 or a pharmaceutically acceptable salt thereof, and harvesting the neural stem cells from the culture; and the like are provided.
摘要翻译: 用于神经干细胞的增殖促进剂,其包含由青霉菌产生的化合物。 CND1007(FERM BP-10917)或其药学上可接受的盐作为活性成分; 由青霉菌产生的新型化合物 CND 1007或其药学上可接受的盐; 一种用于产生神经干细胞的方法,其包括在存在由青霉菌产生的化合物的情况下培养神经干细胞以增殖神经干细胞。 CND1007或其药学上可接受的盐,并从培养物中收获神经干细胞; 等等。
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公开(公告)号:US20120172348A1
公开(公告)日:2012-07-05
申请号:US13386542
申请日:2010-07-22
申请人: Kenji Uchida , Tsutomu Agatsuma , Kazuhiro Hibino , Setsuya Sasho , Kyoichiro Iida , Hideyuki Onodera
发明人: Kenji Uchida , Tsutomu Agatsuma , Kazuhiro Hibino , Setsuya Sasho , Kyoichiro Iida , Hideyuki Onodera
IPC分类号: A61K31/366 , C07D493/04 , C07D491/052 , C07D413/12 , C07D405/12 , A61K31/55 , A61K31/5377 , A61K31/4433 , A61P25/16 , A61P25/28 , A61P25/00 , A61P25/08 , A61P25/22 , A61P25/18 , A61P25/24 , C07D311/78
CPC分类号: C07J73/003 , A61K31/585 , C07J9/00 , C07J73/008 , C07J75/005
摘要: The present invention provides a sterol derivative or a pharmaceutically acceptable salt thereof having an activity to promote proliferation of neural stem cells. Namely, the present invention provides a sterol derivative represented by the general formula (I) (wherein Y represents optionally substituted lower alkyl or the like; Xa and Xb are the same or different, and represent a bond or the like; R1, R2, R3, R4, R7 and R8 are the same or different, and represent a hydrogen atom or the like; R5 and R6 are the same or different, and represent a hydrogen atom or the like; R9 represents a hydrogen atom or the like; R10 and R11 together represent a bond or the like; and R12 represents a hydrogen atom or the like) or a pharmaceutically acceptable salt thereof.
摘要翻译: 本发明提供具有促进神经干细胞增殖的活性的甾醇衍生物或其药学上可接受的盐。 即,本发明提供由通式(I)表示的固醇衍生物(其中Y表示任选取代的低级烷基等; Xa和Xb相同或不同,表示键或类似物; R1,R2, R3,R4,R7和R8相同或不同,表示氢原子等; R5和R6相同或不同,表示氢原子等; R9表示氢原子等; R10 和R 11一起表示键等; R 12表示氢原子等)或其药学上可接受的盐。
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