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公开(公告)号：US5935578A
公开(公告)日：1999-08-10
申请号：US765243
申请日：1996-12-19
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61P15/18 , C07H21/04 , C07K14/47 , C07K14/705 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12R1/19 , C12R1/91
CPC分类号： C07K14/705 , A61K39/00 , Y10S514/843
摘要： The instant invention is drawn to a sperm surface protein in substantially pure form selected from a human PH30 beta chain protein and a mouse PH30 beta chain proteins. Such proteins are useful as contraceptive vaccines in humans and mice respectively, and for identifying small molecules that will disrupt sperm-egg interaction and fertilization.
摘要翻译： PCT No.PCT / US95 / 07295 371 1996年12月19日第 102（e）日期1996年12月19日PCT归档1995年6月6日PCT公布。 公开号WO95 / 35118 日期1995年12月28日本发明描述了选自人PH30β链蛋白质和小鼠PH30β链蛋白质的基本上纯的形式的精子表面蛋白质。 这些蛋白质分别用作人和小鼠的避孕疫苗，并用于鉴定将破坏精子卵相互作用和受精的小分子。
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公开(公告)号：US5693496A
公开(公告)日：1997-12-02
申请号：US264101
申请日：1994-06-20
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61P15/18 , C07H21/04 , C07K14/47 , C07K14/705 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12R1/19 , C12R1/91 , C12N15/63
CPC分类号： C07K14/705 , A61K39/00 , Y10S514/843
摘要： The instant invention is drawn to a DNA encoding a sperm surface protein in substantially pure form selected from a human PH30 beta chain protein and a mouse PH30 beta chain proteins. Such proteins are useful as contraceptive vaccines in humans and mice respectively, and for identifying small molecules that will disrupt sperm-egg interaction and fertilization,
摘要翻译： 将本发明描述为编码选自人PH30β链蛋白和小鼠PH30β链蛋白的基本上纯的形式的精子表面蛋白质的DNA。 这些蛋白质分别用作人和小鼠的避孕疫苗，并且用于鉴定将破坏精子卵相互作用和受精的小分子，
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公开(公告)号：US06750041B2
公开(公告)日：2004-06-15
申请号：US08970266
申请日：1997-11-14
IPC分类号： C12N1500
CPC分类号： C12N15/85 , C07K16/00 , C12N15/907 , C12N2840/20
摘要： A specific locus in the genome of a murine host cell is identified which causes high levels of recombinant gene expression following stable integration, via homologous recombination, of the recombinant gene into the specific chromosomal locus. The selection of a favorable genome locus for the insertion and expression of a recombinant gene is disclosed, as are DNA vectors and host cells.
摘要翻译： 鉴定在鼠宿主细胞的基因组中的特异性基因座，其通过重组基因通过同源重组稳定整合到特定染色体基因座中，导致高水平的重组基因表达。 公开了用于插入和表达重组基因的有利的基因组轨迹的选择，以及DNA载体和宿主细胞。
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公开(公告)号：US06743622B2
公开(公告)日：2004-06-01
申请号：US08744685
申请日：1996-11-07
IPC分类号： C12N1563
CPC分类号： C12N15/85 , C07K16/00 , C12N15/907 , C12N2840/20
摘要： A specific locus in the genome of a murine host cell is identified which causes high levels of recombinant gene expression following stable integration, via homologous recombination, of the recombinant gene into the specific chromosomal locus. The selection of a favorable genome locus for the insertion and expression of a recombinant gene is disclosed, as are DNA vectors and host cells.
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