利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

39 条记录 (耗时 0.021 秒)

    METHODS OF TREATMENT FOR PULMONARY FIBROSIS
    1.
    发明申请
    METHODS OF TREATMENT FOR PULMONARY FIBROSIS 审中-公开
    治疗肺动脉硬化的方法

    公开(公告)号：US20110104175A1

    公开(公告)日：2011-05-05

    申请号：US12995401

    申请日：2009-06-03

    申请人： Kenneth E. Bernstein ,  Sebastien Fuchs

    发明人： Kenneth E. Bernstein ,  Sebastien Fuchs

    IPC分类号： A61K39/395 ,  A61K38/07 ,  A61P11/00

    CPC分类号： C07K14/8103 ,  A61K38/556

    摘要： The invention relates to compositions and methods for treating fibrosing lung diseases, reducing pulmonary cytokine production in animals, treating bleomycin induced lung disease and treating cancer. Specifically, the present subject matter incorporates inactivation of the N-terminal site of an angiotensin-converting enzyme and/or administration of AcSDKP.

    摘要翻译： 本发明涉及用于治疗纤维化肺疾病，减少动物中的肺细胞因子产生，治疗博来霉素诱导的肺部疾病和治疗癌症的组合物和方法。 具体地，本主题包括血管紧张素转换酶的N-末端部位的灭活和/或AcSDKP的施用。

    Bioactive peptides derived from the proteins of egg white by means of enzymatic hydrolysis
    4.
    发明申请
    Bioactive peptides derived from the proteins of egg white by means of enzymatic hydrolysis 有权
    通过酶水解衍生自蛋清蛋白质的生物活性肽

    公开(公告)号：US20060280804A1

    公开(公告)日：2006-12-14

    申请号：US11343263

    申请日：2006-01-30

    申请人： Marta Castro ,  Rosina Lopez-Alonso Fandino ,  Maria Recio Sanchez ,  Maria Ramos Gonzalez ,  Amaya Aleixandre De Artinano

    发明人： Marta Castro ,  Rosina Lopez-Alonso Fandino ,  Maria Recio Sanchez ,  Maria Ramos Gonzalez ,  Amaya Aleixandre De Artinano

    IPC分类号： A61K35/54 ,  C07K14/47

    CPC分类号： C07K14/8103 ,  A23J3/341 ,  A23L33/18 ,  A61K38/012 ,  C07K14/465 ,  C12P21/06

    摘要： The invention relates to the production of ovoproducts containing bioactive peptides from the egg white subjected to enzymatic treatment. Said peptides have an inhibiting activity of the angiotensin converting enzyme (ACE inhibiting activity) in vitro and/or anti-hypertensive activity in rats and/or antioxidant activity. Said ovoproducts, complete hydrolizates, the fractions thereof with low molecular weight or their constituent peptides could be used as therapeutic substances with ACE inhibiting activity and/or anti-hypertensive activity and/or anti-oxidant activity, either as functional food products, food additives or ingredients or pharmaceutical products for the treatment and/or prevention of hypertension in all its forms in humans or animals and for the treatment and/or prevention of any disorder associated with hypertension in humans or animals.

    摘要翻译： 本发明涉及产生含有经过酶处理的蛋白的生物活性肽的产卵。 所述肽在体外和/或抗高血压活性和/或抗氧化活性中具有血管紧张素转换酶（ACE抑制活性）的抑制活性。 所述的卵产物，完全的水解产物，其低分子量的级分或其组成肽可用作具有ACE抑制活性和/或抗高血压活性和/或抗氧化活性的治疗物质，作为功能性食品，食品添加剂 或用于治疗和/或预防人或动物中所有形式的高血压以及用于治疗和/或预防与人或动物中的高血压相关的任何紊乱的成分或药物产品。

    Dipeptidyl peptidase-IV inhibitor
    6.
    发明授权
    Dipeptidyl peptidase-IV inhibitor 有权

    公开(公告)号：US09617300B2

    公开(公告)日：2017-04-11

    申请号：US14383618

    申请日：2013-02-21

    申请人： MORINAGA MILK INDUSTRY CO., LTD

    发明人： Akio Yamada ,  Takuma Sakurai ,  Daisuke Ochi

    IPC分类号： C07K5/083 ,  A61K38/00

    CPC分类号： C07K5/0808 ,  A61K38/00 ,  C07K14/8103 ,  C12N9/485

    摘要： An excellent peptidyl peptidase-IV inhibitor and the like are provided. A peptide consisting of Val-Pro-X wherein X represents an amino acid residue (except for L-proline residue); the aforementioned X is preferably one selected from a basic amino acid residue, an aliphatic neutral amino acid residue, an amide group-carrying neutral amino acid residue, or an aromatic group-carrying neutral amino acid residue; the aforementioned X is preferably one selected from an alanine residue, a glutamine residue, a methionine residue, an asparagine residue, a glycine residue, a valine residue, a tyrosine residue, a serine residue, and a lysine residue; a dipeptidyl peptidase-IV inhibitor, a blood sugar rise suppressing agent, a vascular endothelial disorder suppressing agent, and an angiotensin converting enzyme inhibitor containing the aforementioned peptide as an active ingredient.

    DIPEPTIDYL PEPTIDASE-IV INHIBITOR
    8.
    发明申请
    DIPEPTIDYL PEPTIDASE-IV INHIBITOR 有权
    DIPEPTIDYL PEPTIDASE-IV抑制剂

    公开(公告)号：US20150232510A1

    公开(公告)日：2015-08-20

    申请号：US14383618

    申请日：2013-02-21

    申请人： MORINAGA MILK INDUSTRY CO., LTD

    发明人： Akio Yamada ,  Takuma Sakurai ,  Daisuke Ochi

    IPC分类号： C07K5/083

    CPC分类号： C07K5/0808 ,  A61K38/00 ,  C07K14/8103 ,  C12N9/485

    摘要： An excellent peptidyl peptidase-IV inhibitor and the like are provided. A peptide consisting of Val-Pro-X wherein X represents an amino acid residue (except for L-proline residue); the aforementioned X is preferably one selected from a basic amino acid residue, an aliphatic neutral amino acid residue, an amide group-carrying neutral amino acid residue, or an aromatic group-carrying neutral amino acid residue; the aforementioned X is preferably one selected from an alanine residue, a glutamine residue, a methionine residue, an asparagine residue, a glycine residue, a valine residue, a tyrosine residue, a serine residue, and a lysine residue; a dipeptidyl peptidase-IV inhibitor, a blood sugar rise suppressing agent, a vascular endothelial disorder suppressing agent, and an angiotensin converting enzyme inhibitor containing the aforementioned peptide as an active ingredient.

    摘要翻译： 提供了优异的肽基肽酶-IV抑制剂等。 由Val-Pro-X组成的肽，其中X表示氨基酸残基（L-脯氨酸残基除外）; 上述X优选选自碱性氨基酸残基，脂肪族中性氨基酸残基，含酰胺基的中性氨基酸残基或携带芳族基团的中性氨基酸残基; 上述X优选选自丙氨酸残基，谷氨酰胺残基，甲硫氨酸残基，天冬酰胺残基，甘氨酸残基，缬氨酸残基，酪氨酸残基，丝氨酸残基和赖氨酸残基; 二肽基肽酶-IV抑制剂，血糖升高抑制剂，血管内皮病症抑制剂和含有上述肽作为有效成分的血管紧张素转换酶抑制剂。

    DPP-4 INHIBITOR
    9.
    发明申请
    DPP-4 INHIBITOR 有权
    DPP-4抑制剂

    公开(公告)号：US20140309401A1

    公开(公告)日：2014-10-16

    申请号：US14356023

    申请日：2012-11-02

    申请人： NIPPI, INCORPORATED

    发明人： Osamu Hayashida ,  Masashi Kusubata ,  Yuji Atsuzawa ,  Yuki Taga ,  Youichi Koyama ,  Shunji Hattori

    IPC分类号： C07K7/06 ,  C07K5/10 ,  C07K5/06 ,  C07K5/08

    CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K5/06 ,  C07K5/06026 ,  C07K5/06043 ,  C07K5/06078 ,  C07K5/06165 ,  C07K5/08 ,  C07K5/0806 ,  C07K5/0808 ,  C07K5/0823 ,  C07K5/10 ,  C07K5/1008 ,  C07K14/78 ,  C07K14/8103 ,  C12N9/485 ,  C12Y304/14005

    摘要： A DPP-4 inhibitor comprising a peptide represented by the formula (1): Xe-Pro/Ala/Hyp-Xa-Xb-Xc-Xd (wherein Xe is an amino acid residue with an isoelectric point of 5.9 to 6.3; Pro/Ala/Hyp represents Pro, Ala, or Hyp; Xa is an amino acid residue other than Hyp, Pro, and Arg, or deletion; Xb is Gly, Pro, or deletion; Xc is Pro, Ala, or deletion; and Xd is an amino acid residue or deletion) as an active component. The inhibitor can be expected to bring out an effect of lowering blood glucose levels by enhancing effects of incretins; and the inhibitor may be used as a therapeutic agent for diabetes and, in addition, can act on the immune system or the like to be thus used in treatment for skin diseases or the like.

    摘要翻译： 包含由式（1）表示的肽的DPP-4抑制剂：Xe-Pro / Ala / Hyp-Xa-Xb-Xc-Xd（其中Xe是等电点为5.9至6.3的氨基酸残基; Pro / Ala / Hyp代表Pro，Ala或Hyp; Xa是Hyp，Pro和Arg以外的氨基酸残基或缺失; Xb是Gly，Pro或缺失; Xc是Pro，Ala或缺失; Xd是 氨基酸残基或缺失）作为活性成分。 预期抑制剂可以通过增强胰岛素的作用来产生降低血糖水平的作用; 并且抑制剂可以用作糖尿病的治疗剂，并且另外可以作用于免疫系统等，从而用于治疗皮肤疾病等。

    Peptides for treating and preventing immune-related disorders, including treating and preventing infection by modulating innate immunity
    10.
    发明授权
    Peptides for treating and preventing immune-related disorders, including treating and preventing infection by modulating innate immunity 有权
    用于治疗和预防免疫相关疾病的肽，包括通过调节先天免疫来治疗和预防感染

    公开(公告)号：US08791061B2

    公开(公告)日：2014-07-29

    申请号：US13457162

    申请日：2012-04-26

    申请人： Oreola Donini ,  Annett Rozek ,  Shannon Wayne Lentz

    发明人： Oreola Donini ,  Annett Rozek ,  Shannon Wayne Lentz

    IPC分类号： A61K38/00 ,  C07K5/10

    CPC分类号： C07K14/8103 ,  A61K38/00 ,  C07K5/0806 ,  C07K5/081 ,  C07K5/0815 ,  C07K5/0817 ,  C07K5/1019 ,  C07K7/06 ,  C07K7/08 ,  C12Q1/37 ,  G01N33/569 ,  G01N33/6893 ,  G01N2800/24 ,  G01N2800/26 ,  G01N2800/52 ,  Y02A50/473 ,  Y02A50/481 ,  Y02A50/491

    摘要： In one aspect, the present invention provides isolated novel peptides that can be used to modulate innate immunity in a subject and/or for the treatment of an immune-related disorder, including treating and preventing infection by modulating innate immunity. Also provided are an agent reactive with the peptide, a pharmaceutical composition that includes the peptide, an isolated nucleic acid molecule encoding the peptide, a recombinant nucleic acid construct that includes the nucleic acid molecule, at least one host cell comprising the recombinant nucleic acid construct, and a method of producing the peptide using the host cell. The present invention further provides a method for treating and/or preventing infection in a subject by administering the peptide of the invention to the subject, thereby modulating innate immunity in the subject. Additionally, the present invention provides a method for predicting whether a subject would be responsive to treatment with a peptide of the invention.

    摘要翻译： 一方面，本发明提供分离的新型肽，其可用于调节受试者中的先天免疫和/或用于治疗免疫相关病症，包括通过调节先天免疫来治疗和预防感染。 还提供了与肽反应的试剂，包含肽，分离的编码该肽的核酸分子的药物组合物，包含该核酸分子的重组核酸构建体，至少一个宿主细胞，其包含重组核酸构建体 ，以及使用该宿主细胞产生该肽的方法。 本发明还提供了通过将本发明的肽给予受试者来治疗和/或预防受试者感染的方法，从而调节受试者的先天免疫。 另外，本发明提供了一种用于预测受试者是否对本发明的肽的治疗有反应的方法。