-
公开(公告)号：US5552303A
公开(公告)日：1996-09-03
申请号：US31399
申请日：1993-03-08
申请人： Kenneth Grabstein , Dirk Anderson , June Eisenman , Victor Fung , Charles Rauch
发明人： Kenneth Grabstein , Dirk Anderson , June Eisenman , Victor Fung , Charles Rauch
CPC分类号： C07K14/5443 , A61K38/00 , C07K2319/02
摘要： There is disclosed a mammalian epithelium-derived T-cell factor (EFT) polypeptide, derivatives thereof, DNA sequences, recombinant DNA molecules and transformed host cells that produce ETF polypeptides. More particularly, this invention provides isolated mammalian ETF polypeptides and derivatives thereof that regulate events in T-lymphocyte proliferation.
摘要翻译： 公开了哺乳动物上皮衍生的T细胞因子（EFT）多肽，其衍生物，DNA序列，重组DNA分子和产生ETF多肽的转化的宿主细胞。 更具体地，本发明提供分离的哺乳动物ETF多肽及其衍生物，其调节T淋巴细胞增殖中的事件。
-
公开(公告)号：US20080090762A1
公开(公告)日：2008-04-17
申请号：US11704726
申请日：2007-02-09
申请人： Kenneth Grabstein , Dirk Anderson , June Eisenman , Victor Fung , Charles Rauch
发明人： Kenneth Grabstein , Dirk Anderson , June Eisenman , Victor Fung , Charles Rauch
IPC分类号： A61K38/17 , A61P1/04 , A61P31/18 , C07H21/04 , C07K14/47 , C07K16/18 , C12N15/63 , C12N5/06 , C12N5/12 , C12P21/02
CPC分类号： C07K14/5443 , A61K38/00
摘要： Nucleic acid sequences which encode biologically active ETF, expression vectors which direct the expression of ETF, ETF polypeptides, antibodies which specifically bind ETF and processes for preparing the same are disclosed. Also disclosed are methods for treating or preventing gastrointestinal diseases and HIV or HIV-associated diseases.
摘要翻译： 公开了编码生物活性ETF的核酸序列，指导ETF表达的表达载体，ETF多肽，特异性结合ETF的抗体及其制备方法。 还公开了治疗或预防胃肠道疾病和HIV或HIV相关疾病的方法。
-
公开(公告)号：US5985262A
公开(公告)日：1999-11-16
申请号：US794524
申请日：1997-02-03
IPC分类号： A61K38/20 , A61K39/395 , C07K14/54 , C07K14/725 , C07K16/24 , C12N5/12 , C12N15/24
CPC分类号： A61K38/1709 , Y10S514/885
摘要： Nucleic acid sequences which encode biologically active EMF, expression vectors which direct the expression of ETF, ETE polypeptides, antibodies which specffically bind ETF and processes for preparing the same are disclosed. Also disclosed are methods for treating or preventing gastrointestinal diseases and HIV or HIV-associated diseases.
摘要翻译： 公开了编码生物活性EMF的核酸序列，指导ETF表达的表达载体，ETE多肽，特异性结合ETF的抗体及其制备方法。 还公开了治疗或预防胃肠道疾病和HIV或HIV相关疾病的方法。
-
公开(公告)号：US5892001A
公开(公告)日：1999-04-06
申请号：US725969
申请日：1996-10-04
IPC分类号： A61K38/20 , A61K39/395 , C07K14/54 , C07K14/725 , C07K16/24 , C12N5/12 , C12N15/24
CPC分类号： A61K38/1709 , Y10S514/885
摘要： Nucleic acid sequences which encode biologically active ETF, expression vectors which direct the expression of ETF, ETF polypeptides, antibodies which specifically bind ETF and processes for preparing the same are disclosed. Also disclosed are methods for treating or preventing gastrointestinal diseases and HIV or HIV-associated diseases.
摘要翻译： 公开了编码生物活性ETF的核酸序列，指导ETF表达的表达载体，ETF多肽，特异性结合ETF的抗体及其制备方法。 还公开了治疗或预防胃肠道疾病和HIV或HIV相关疾病的方法。
-
5.发明授权公开(公告)号：US07192935B1
公开(公告)日：2007-03-20
申请号：US09724841
申请日：2000-11-28
CPC分类号： C07K14/5443 , A61K38/00
摘要： Nucleic acid sequences which encode biologically active ETF, expression vectors which direct the expression of ETF, ETF polypeptides, antibodies which specifically bind ETF and processes for preparing the same are disclosed. Also disclosed are methods for treating or preventing gastrointestinal diseases and HIV or HIV-associated diseases.
摘要翻译： 公开了编码生物活性ETF的核酸序列，指导ETF表达的表达载体，ETF多肽，特异性结合ETF的抗体及其制备方法。 还公开了治疗或预防胃肠道疾病和HIV或HIV相关疾病的方法。
-
6.发明授权Method for treating or preventing gastrointestinal disease with epithelium-derived T-cell factor 失效用上皮衍生的T细胞因子治疗或预防胃肠道疾病的方法
公开(公告)号：US5707616A
公开(公告)日：1998-01-13
申请号：US726817
申请日：1996-10-04
IPC分类号： A61K38/20 , A61K39/395 , C07K14/54 , C07K14/725 , C07K16/24 , C12N5/12 , C12N15/24
CPC分类号： A61K38/1709 , Y10S514/885
摘要： Nucleic acid sequences which encode biologically active ETF, expression vectors which direct the expression of ETF, ETF polypeptides, antibodies which specifically bind ETF and processes for preparing the same are disclosed. Also disclosed are methods for treating or preventing gastrointestinal diseases and HIV or HIV-associated diseases.
摘要翻译： 公开了编码生物活性ETF的核酸序列，指导ETF表达的表达载体，ETF多肽，特异性结合ETF的抗体及其制备方法。 还公开了治疗或预防胃肠道疾病和HIV或HIV相关疾病的方法。
-
7.发明授权Method of treating cancer by administering an epithelum-derived T-cell factor 失效通过施用上皮衍生的T细胞因子治疗癌症的方法公开(公告)号：US07625553B2
公开(公告)日：2009-12-01
申请号：US11704726
申请日：2007-02-09
CPC分类号： C07K14/5443 , A61K38/00
摘要： Nucleic acid sequences which encode biologically active ETF, expression vectors which direct the expression of ETF, ETF polypeptides, antibodies which specifically bind ETF and processes for preparing the same are disclosed. Also disclosed are methods for treating or preventing gastrointestinal diseases and HIV or HIV-associated diseases.
摘要翻译： 公开了编码生物活性ETF的核酸序列，指导ETF表达的表达载体，ETF多肽，特异性结合ETF的抗体及其制备方法。 还公开了治疗或预防胃肠道疾病和HIV或HIV相关疾病的方法。
-
公开(公告)号：US06184359B2
公开(公告)日：2001-02-06
申请号：US09189193
申请日：1998-11-09
IPC分类号： C07K1624
CPC分类号： A61K38/1709 , Y10S514/885
摘要： Nucleic acid sequences which encode biologically active ETF, expression vectors which direct the expression of ETF, ETF polypeptides, antibodies which specifically bind ETF and processes for preparing the same are disclosed. Also disclosed are methods for treating or preventing gastrointestinal diseases and HIV or HIV-associated diseases.
摘要翻译： 公开了编码生物活性ETF的核酸序列，指导ETF表达的表达载体，ETF多肽，特异性结合ETF的抗体及其制备方法。 还公开了治疗或预防胃肠道疾病和HIV或HIV相关疾病的方法。
-
公开(公告)号：US5574138A
公开(公告)日：1996-11-12
申请号：US393305
申请日：1995-02-22
IPC分类号： A61K38/20 , A61K39/395 , C07K14/54 , C07K14/725 , C07K16/24 , C12N5/12 , C12N15/24
CPC分类号： A61K38/1709 , Y10S514/885
摘要： Nucleic acid sequences which encode biologically active ETF, expression vectors which direct the expression of ETF, ETF polypeptides, antibodies which specifically bind ETF and processes for preparing the same are disclosed. Also disclosed are methods for treating or preventing gastrointestinal diseases and HIV or HIV-associated diseases.
摘要翻译： 公开了编码生物活性ETF的核酸序列，指导ETF表达的表达载体，ETF多肽，特异性结合ETF的抗体及其制备方法。 还公开了治疗或预防胃肠道疾病和HIV或HIV相关疾病的方法。
-
10.发明申请Methods for generating high titer helper-free preparations of released recombinant AAV vectors 审中-公开用于产生释放的重组AAV载体的高滴度无助剂制剂的方法公开(公告)号：US20050266567A1
公开(公告)日：2005-12-01
申请号：US11170269
申请日：2005-06-28
申请人： Edward Atkinson , Victor Fung , Perry Wilkins , Ryan Takeya , Thomas Reynolds , Ian Aranha
发明人： Edward Atkinson , Victor Fung , Perry Wilkins , Ryan Takeya , Thomas Reynolds , Ian Aranha
IPC分类号： A61K48/00 , C07C2/32 , C07D207/32 , C07D207/34 , C07D207/50 , C07D295/30 , C07D401/14 , C07D409/14 , C07F7/08 , C07F9/572 , C07F9/58 , C07F15/04 , C07K14/015 , C08F4/659 , C08F10/00 , C08F110/02 , C08F110/14 , C08F210/16 , C12N5/10 , C12N7/00 , C12N7/02 , C12N15/861 , C12N15/864
CPC分类号： C07D207/32 , A61K48/0091 , C07C2/32 , C07C2531/22 , C07D207/34 , C07D207/50 , C07D295/30 , C07D401/14 , C07D409/14 , C07F7/0812 , C07F9/572 , C07F9/58 , C07F15/045 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2750/14122 , C12N2750/14143 , C12N2750/14151 , C12N2750/14152
摘要： This invention provides methods and compositions for producing high titer, substantially purified preparations of recombinant adeno-associated virus (AAV) that can be used as vectors for gene delivery. At the onset of vector production, AAV producer cells of this invention typically comprise one or more AAV packaging genes, an AAV vector comprising a heterologous (i.e. non-AAV) transgene of interest, and a helper virus such as an adenovirus. The AAV vector preparations produced are generally replication incompetent but are capable of mediating delivery of a transgene of interest (such as a therapeutic gene) to any of a wide variety of tissues and cells. The AAV vector preparations produced according to this invention are also substantially free of helper virus as well as helper viral and cellular proteins and other contaminants. The invention described herein provides methods of producing rAAV particles by culturing producer cells under conditions, such as temperature and pH, that promote release of virus. Also provided is a quantitative, high-throughput assay useful in the assessment of viral infectivity and replication, as well as in the screening of agent that affect viral infectivity and/or replication.
摘要翻译： 本发明提供用于生产可用作基因递送载体的重组腺相关病毒（AAV）的高滴度，基本纯化的制剂的方法和组合物。 在载体生产开始时，本发明的AAV生产细胞通常包含一个或多个AAV包装基因，包含感兴趣的异源（即非AAV）转基因的AAV载体和辅助病毒如腺病毒。 产生的AAV载体制剂通常是复制无能力的，但能够介导感兴趣的转基因（例如治疗基因）到多种组织和细胞中的任何一种。 根据本发明制备的AAV载体制剂也基本上不含辅助病毒以及辅助病毒和细胞蛋白质和其它污染物。 本文描述的本发明提供了通过在促进病毒释放的条件例如温度和pH下培养生产细胞来生产rAAV颗粒的方法。 还提供了用于评估病毒感染性和复制以及影响病毒感染性和/或复制的试剂筛选的定量，高通量测定。
-
-
-
-
-
-
-
-
-
搜索结果
13 条记录 (耗时 0.027 秒)
