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公开(公告)号:US07632492B2
公开(公告)日:2009-12-15
申请号:US11743608
申请日:2007-05-02
申请人: Kenneth H. Grabstein , Andrea Wang , Natalie Winblade Nairn , Stephen McCraith , Deepshikha Datta
发明人: Kenneth H. Grabstein , Andrea Wang , Natalie Winblade Nairn , Stephen McCraith , Deepshikha Datta
CPC分类号: C12P21/02 , A61K38/00 , C07K14/565 , C07K2319/22 , C07K2319/30 , C07K2319/40 , C07K2319/55 , Y02A50/463
摘要: The invention provides compositions and methods of identifying, modifying and producing modified target molecules, including therapeutic molecules by modification with non-natural amino acids. Certain aspects of the invention include methods of adding a chemical moiety to a target molecule, and the compositions resulting therefrom. Certain aspects of the invention also relate to kits for identifying, modifying and producing modified target molecules described herein.
摘要翻译: 本发明提供通过用非天然氨基酸修饰来鉴定,修饰和产生修饰的靶分子(包括治疗分子)的组合物和方法。 本发明的某些方面包括向目标分子中加入化学部分的方法和由其产生的组合物。 本发明的某些方面还涉及用于鉴定,修饰和产生本文所述的修饰的靶分子的试剂盒。