公开(公告)号：US09198877B2

公开(公告)日：2015-12-01

申请号：US13129638

申请日：2009-11-17

申请人： Kristin Jackson ,  Kenneth J. Miller

发明人： Kristin Jackson ,  Kenneth J. Miller

IPC分类号： A61K9/70 ,  A61F13/00

CPC分类号： A61K9/7092 ,  A61F2013/00646 ,  A61F2013/0071 ,  A61F2013/00906 ,  A61K8/0208 ,  A61K9/7053 ,  A61K9/7061 ,  A61K9/7069 ,  A61K9/7084

摘要： A transdermal drug-containing dosage unit comprises: a backing layer substantially impervious to the drug to be delivered transdermally; a first polymeric adhesive matrix, in contact with the backing layer, having dispersed therein the drug and having a first delivery profile of the drug; a second polymeric adhesive matrix, in contact with said first polymeric adhesive matrix, having dispersed therein the drug and having a second delivery profile of the drug, wherein said second delivery profile is different from said first delivery profile; and a release liner in contact with the second polymeric adhesive matrix. The first polymeric adhesive matrix can release the drug more quickly or more slowly than the second polymeric adhesive matrix. Through the selection of the two matrices, the delivery profile of the drug through the skin can be selectively modified and controlled.

摘要翻译： 含透皮药物的剂量单位包括：基本上不透过经皮递送的药物的背衬层; 与背衬层接触的第一聚合物粘合剂基质，其中分散有药物并具有药物的第一递送曲线; 与所述第一聚合物粘合剂基质接触的第二聚合物粘合剂基质，其中分散有药物并具有药物的第二递送分布，其中所述第二递送分布与所述第一递送分布不同; 以及与第二聚合物粘合剂基质接触的剥离衬垫。 第一聚合物粘合剂基质可以比第二聚合物粘合剂基质更快或更慢地释放药物。 通过选择两个基质，可以选择性地改变和控制药物通过皮肤的递送特征。

公开(公告)号：US20080226698A1

公开(公告)日：2008-09-18

申请号：US11725159

申请日：2007-03-16

申请人： Jiansheng Tang ,  Joseph M. Deverich ,  Kenneth J. Miller ,  Russell D. Beste

发明人： Jiansheng Tang ,  Joseph M. Deverich ,  Kenneth J. Miller ,  Russell D. Beste

IPC分类号： A61K31/215 ,  A61F13/02 ,  A61K31/4353 ,  A61K31/4355 ,  A61K9/70 ,  A61P43/00

CPC分类号： A61K9/7053 ,  A61K9/7069

摘要： The present invention refers to a transdermal delivery device comprising a backing layer, an adhesive matrix layer comprising a supersaturated concentration of an active agent substantially in amorphous form within the adhesive matrix, and a release liner. The present invention also refers to a method of preparing an adhesive matrix containing at least one supersaturated active agent substantially in amorphous form. Further, the present invention refers to a method to stabilize and a method to reestablish the meta-stable amorphous-drug transdermal system during its manufacturing, storing, shipping and handling process.

摘要翻译： 本发明涉及一种透皮递送装置，其包括背衬层，包含过饱和浓度的基本上为无定形形式的粘合剂基质中的活性剂的粘合剂基质层和释放衬垫。 本发明还涉及制备含有至少一种基本上为无定形形式的过饱和活性剂的粘合剂基质的方法。 此外，本发明涉及一种稳定化方法以及在其制造，储存，运输和处理过程中重新建立间 - 稳定非晶药物透皮系统的方法。

公开(公告)号：US09731490B2

公开(公告)日：2017-08-15

申请号：US13299747

申请日：2011-11-18

申请人： Kenneth J. Miller

发明人： Kenneth J. Miller

IPC分类号： B32B38/04 ,  B32B37/12 ,  C09J7/02 ,  B32B38/18 ,  C09J7/00 ,  A61F13/02 ,  B32B37/00

CPC分类号： B32B37/02 ,  A61F13/0253 ,  B32B37/0053 ,  B32B38/04 ,  B32B38/1816 ,  B32B2038/045 ,  C09J7/00 ,  C09J7/10 ,  C09J7/38 ,  C09J2201/36 ,  C09J2201/606 ,  Y10T156/1059 ,  Y10T156/1062 ,  Y10T156/1069 ,  Y10T156/1075 ,  Y10T156/1077

摘要： A method allows for rapid manufacture of relatively thick adhesive coatings using a continuous process, where a single thin coating is continuously converted into a single thicker adhesive laminate. An exemplary process includes the steps of: (1) producing a web having a first surface with an adhesive layer and a second surface with a release liner; (2) slitting the web longitudinally into a first section and a second section; (3) laminating a backing film to the adhesive layer of the first section; (4) removing the release liner of the laminate of step (3) exposing the adhesive layer of the first section; and (5) laminating the second section to the laminate of step (4), wherein the adhesive layer of the laminate of step (4) is combined with the adhesive layer of the second section.

公开(公告)号：US20120145320A1

公开(公告)日：2012-06-14

申请号：US13192178

申请日：2011-07-27

申请人： Kenneth J. Miller ,  Sharad K. Govil ,  Kulijit Singh Bhatia

发明人： Kenneth J. Miller ,  Sharad K. Govil ,  Kulijit Singh Bhatia

IPC分类号： B32B37/12

CPC分类号： A61K9/7069 ,  A61K31/445 ,  Y10T156/10

摘要： Silicone adhesive formulations are provided, in which fentanyl particles are suspended one or more a solvated silicone adhesives. The formulations can be used for manufacturing improved, matrix-type transdermal devices for administering fentanyl.

摘要翻译： 提供了硅酮粘合剂制剂，其中芬太尼颗粒悬浮在一种或多种溶剂化硅氧烷粘合剂上。 制剂可用于制造用于施用芬太尼的改进的基质型透皮装置。

公开(公告)号：US4275581A

公开(公告)日：1981-06-30

申请号：US918630

申请日：1978-06-23

申请人： Kenneth J. Miller

发明人： Kenneth J. Miller

IPC分类号： B21D5/01 ,  B21D13/00 ,  B21D13/02 ,  B21F1/04 ,  F28F1/30

CPC分类号： B21F1/04 ,  B21D13/00 ,  B21D13/02 ,  F28F3/046

摘要： An apparatus (40) and method for increasing the fin density of a serpentine sheet (10) having a plurality of fins (14a, 14b, 14c), each fin having two sides (16, 18) coupled together at one end (20) with a space (22) between the sides. Blocks (30, 32) having receptacles (30a, 32a) for receiving the ends (20, 24) of one side (16) of a fin (14a) and being near opposite surfaces (A, B) of the sheet (10) are moved vertically into contact with such ends. Simultaneously, blades (34, 36), being near the opposite surfaces (A, B) of the sheet (10) are moved vertically into position at the other side (18) of the fin (14a). Then, the blades (34, 36) are moved horizontally towards the blocks (30, 32), which are now held stationary, to compress the fin (14a) a predetermined amount by moving the other fin side towards the one fin side. The blocks and blades are then withdrawn from the sheet to move another fin (14b) into position for another compressing operation. The apparatus (40) includes a mechanism (70) to prevent the sheet from fishtailing when a fin is being compressed.

摘要翻译： 一种用于增加具有多个翅片（14a，14b，14c）的蛇形片（10）的翅片密度的装置（40）和方法，每个翅片在一端（20）处联接在一起的两侧（16,18） 在两侧之间具有空间（22）。 具有容纳翅片（14a）的一侧（16）的端部（20,24）并且接近片材（10）的相对表面（A，B）的插座（30a，32a）的块体（30,32） 垂直移动与这些端部接触。 同时，在片（10）的相对表面（A，B）附近的叶片（34,36）垂直移动到翅片（14a）的另一侧（18）的位置。 然后，将刀片（34,36）水平地移向现在保持静止的块（30,32），以通过将另一个翅片侧移向一个翅片侧来将翅片（14a）压缩预定量。 然后将块和叶片从纸张中取出以将另一个翅片（14b）移动到另一个压缩操作的位置。 装置（40）包括一个机构（70），用于防止片状物在被压缩时被捕获。

公开(公告)号：US4171015A

公开(公告)日：1979-10-16

申请号：US782200

申请日：1977-03-28

申请人： Charles W. Bucey ,  Kenneth J. Miller ,  Ronald R. Robinson

发明人： Charles W. Bucey ,  Kenneth J. Miller ,  Ronald R. Robinson

IPC分类号： B21D53/04 ,  F28F1/26

CPC分类号： B21D53/04 ,  F28F1/26 ,  Y10T29/49378

摘要： A heat exchanger tube has a first asymmetrically corrugated sheet portion having an opposite pair of longitudinally extending side edge portions, a plurality of substantially transversely extending ribs and a substantially uninterrupted inner surface, a second asymmetrically corrugated sheet portion having an opposite pair of longitudinally extending side edge portions, a plurality of substantially transversely extending ribs and a substantially uninterrupted inner surface, and at least one joint for connecting side edge portions of the first and second corrugated sheet portions forming a tube and providing an internal flow path for a first fluid and a plurality of external flow paths for a second fluid.

摘要翻译： 热交换器管具有第一不对称波纹片部分，其具有相对的一对纵向延伸的侧边缘部分，多个基本上横向延伸的肋条和基本上不间断的内表面，第二不对称波纹片部分具有相对的一对纵向延伸的侧面 边缘部分，多个基本上横向延伸的肋和基本上不间断的内表面，以及用于连接第一和第二波纹片部分的侧边缘部分的至少一个接头，形成管并提供用于第一流体的内部流动路径 用于第二流体的多个外部流动路径。

公开(公告)号：US20130319595A1

公开(公告)日：2013-12-05

申请号：US13872329

申请日：2013-04-29

申请人： Kenneth J. Miller ,  Sharad K. Govil ,  Kuljit Singh Bhatia

发明人： Kenneth J. Miller ,  Sharad K. Govil ,  Kuljit Singh Bhatia

IPC分类号： A61K9/70

CPC分类号： A61K9/7069 ,  A61K31/445 ,  Y10T156/10

摘要： Silicone adhesive formulations are provided, in which fentanyl particles are suspended one or more a solvated silicone adhesives. The formulations can be used for manufacturing improved, matrix-type transdermal devices for administering fentanyl.

公开(公告)号：USD355457S

公开(公告)日：1995-02-14

申请号：US11785

申请日：1993-08-16

申请人： Kenneth J. Miller

设计人： Kenneth J. Miller

公开(公告)号：US4867868A

公开(公告)日：1989-09-19

申请号：US200100

申请日：1988-05-31

申请人： Kenneth J. Miller ,  Wu-Wey Wen

发明人： Kenneth J. Miller ,  Wu-Wey Wen

IPC分类号： B03D1/001 ,  B03D1/02

CPC分类号： B03D1/02 ,  B03D1/008 ,  B03D1/012 ,  B03D2201/02 ,  B03D2201/04 ,  B03D2201/06 ,  B03D2203/02 ,  B03D2203/08

摘要： Pyritic sulfur is removed from coal or other carbonaceous material through the use of humic acid as a coal flotation depressant. Following the removal of coarse pyrite, the carbonaceous material is blended with humic acid, a pyrite flotation collector and a frothing agent within a flotation cell to selectively float pyritic sulfur leaving clean coal as an underflow.

摘要翻译： 通过使用腐殖酸作为煤浮选抑制剂，从煤或其他碳质材料中除去硫铁矿。 除去粗黄铁矿后，碳质材料与浮选槽内的腐殖酸，黄铁矿浮选捕收剂和起泡剂混合，以选择性地将黄铁矿硫离开清洁煤作为下溢。

公开(公告)号：US4255015A

公开(公告)日：1981-03-10

申请号：US939013

申请日：1978-09-01

申请人： Washington Adams ,  Kenneth J. Miller

发明人： Washington Adams ,  Kenneth J. Miller

IPC分类号： G02B6/42 ,  G02B5/14

CPC分类号： G02B6/4248 ,  G02B6/4204 ,  G02B6/4292

摘要： A fiber optic cable is coupled with an electro-optic transducer through a ferrule which terminates the cable that is inserted in a passageway of a housing which is mounted on a planar surface so that the passageway is transverse thereto. A cover placed over the housing and latched thereto isolates the ferrule from dust and external light and insures its proper alignment with the electro-optic element, which is inserted in the passageway from the opposite end via an opening in the planar surface, by exerting a spring force on a flange of the ferrule which is a greater distance from the end of the ferrule than the distance between the passageway entrance to the ferrule and the electro-optic transducer when positioned in the passageway so that the fiber optic cable and transducer abut one another upon placement in the passageway to effect an efficacious coupling.

摘要翻译： 光纤电缆通过套管与电光换能器耦合，所述套圈终止插入在安装在平坦表面上的壳体的通道中的电缆，使得通道横向于其。 放置在壳体上并被锁定在其上的盖将隔套与灰尘和外部光隔离，并确保其与电光元件的正确对准，该电光元件通过施加一个或多个通过在平坦表面中的开口从相对端插入通道中 在套圈的凸缘上的弹簧力，其比套圈的通道入口与电光换能器之间的距离比套圈的端部更大的距离，当定位在通道中时，光纤电缆和换能器抵接在一个 另一个放置在通道中以实现有效的耦合。