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1.发明授权9-deazaadenosine and its 5'-.alpha.-D-glycopyranoside isolated from the cyanobacterium anabaena affinis strain VS-1 失效9-脱氮腺苷及其5'-α-D-吡喃葡萄糖苷从蓝假丝酵母菌VS-1
公开(公告)号：US5569757A
公开(公告)日：1996-10-29
申请号：US39984
申请日：1993-03-30
CPC分类号： C12P19/58 , C07H15/26 , C12P17/182 , C12P19/40 , Y10S435/946
摘要： The present invention is based upon the discovery that a MeOH extract of Anabaena affinis strain VS-1 showed strong cytotoxicity to L1210 murine leukemia cells, and from that extract was isolated the compounds having the following structures, Compounds 1 and 2. These two compounds are believed to be responsible for the cytotoxicity of the marine organism. This is the first report of the isolation and characterization of pyrrolo[3,2-d] pyrimidine derivatives as biosynthetic products. ##STR1##
摘要翻译： 本发明基于以下发现：鱼腥藻属菌株VS-1的MeOH提取物对L1210鼠白血病细胞显示出强的细胞毒性，从该提取物中分离出具有以下结构的化合物，化合物1和2。这两种化合物是 被认为负责海洋生物体的细胞毒性。 这是吡咯并[3,2-d]嘧啶衍生物作为生物合成产物的分离和表征的第一份报告。
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2.发明授权9-deazaadenosine and its 5'-.alpha.-D-glycopyranoside isolated from the cyanobacterium Anabaena affinis strain VS-1 失效9-脱氮腺苷及其5'-α-D-吡喃葡萄糖苷分离自蓝细菌An鱼VS-1
公开(公告)号：US5683895A
公开(公告)日：1997-11-04
申请号：US477494
申请日：1995-06-07
CPC分类号： C12P19/58 , C07H15/26 , C12P17/182 , C12P19/40 , Y10S435/946
摘要： The present invention is based upon the discovery that a MeOH extract of Anabaena affinis strain VS-1 showed strong cytotoxicity to L1210 murine leukemia cells, and from that extract was isolated the compounds having the following structures, Compounds 1 and 2. These two compounds are believed to be responsible for the cytotoxicity of the marine organism. This is the first report of the isolation and characterization of pyrrolo�3,2-d!pyrimidine derivatives as biosynthetic products. ##STR1##
摘要翻译： 本发明基于以下发现：鱼腥藻属菌株VS-1的MeOH提取物对L1210鼠白血病细胞显示出强的细胞毒性，从该提取物中分离出具有以下结构的化合物，化合物1和2。这两种化合物是 被认为负责海洋生物体的细胞毒性。 这是吡咯并[3,2-d]嘧啶衍生物作为生物合成产物的分离和表征的第一份报告。
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