-
1.发明授权9-deazaadenosine and its 5'-.alpha.-D-glycopyranoside isolated from the cyanobacterium Anabaena affinis strain VS-1 失效9-脱氮腺苷及其5'-α-D-吡喃葡萄糖苷分离自蓝细菌An鱼VS-1
公开(公告)号：US5683895A
公开(公告)日：1997-11-04
申请号：US477494
申请日：1995-06-07
CPC分类号： C12P19/58 , C07H15/26 , C12P17/182 , C12P19/40 , Y10S435/946
摘要： The present invention is based upon the discovery that a MeOH extract of Anabaena affinis strain VS-1 showed strong cytotoxicity to L1210 murine leukemia cells, and from that extract was isolated the compounds having the following structures, Compounds 1 and 2. These two compounds are believed to be responsible for the cytotoxicity of the marine organism. This is the first report of the isolation and characterization of pyrrolo�3,2-d!pyrimidine derivatives as biosynthetic products. ##STR1##
摘要翻译： 本发明基于以下发现：鱼腥藻属菌株VS-1的MeOH提取物对L1210鼠白血病细胞显示出强的细胞毒性，从该提取物中分离出具有以下结构的化合物，化合物1和2。这两种化合物是 被认为负责海洋生物体的细胞毒性。 这是吡咯并[3,2-d]嘧啶衍生物作为生物合成产物的分离和表征的第一份报告。
-
2.发明授权9-deazaadenosine and its 5'-.alpha.-D-glycopyranoside isolated from the cyanobacterium anabaena affinis strain VS-1 失效9-脱氮腺苷及其5'-α-D-吡喃葡萄糖苷从蓝假丝酵母菌VS-1
公开(公告)号：US5569757A
公开(公告)日：1996-10-29
申请号：US39984
申请日：1993-03-30
CPC分类号： C12P19/58 , C07H15/26 , C12P17/182 , C12P19/40 , Y10S435/946
摘要： The present invention is based upon the discovery that a MeOH extract of Anabaena affinis strain VS-1 showed strong cytotoxicity to L1210 murine leukemia cells, and from that extract was isolated the compounds having the following structures, Compounds 1 and 2. These two compounds are believed to be responsible for the cytotoxicity of the marine organism. This is the first report of the isolation and characterization of pyrrolo[3,2-d] pyrimidine derivatives as biosynthetic products. ##STR1##
摘要翻译： 本发明基于以下发现：鱼腥藻属菌株VS-1的MeOH提取物对L1210鼠白血病细胞显示出强的细胞毒性，从该提取物中分离出具有以下结构的化合物，化合物1和2。这两种化合物是 被认为负责海洋生物体的细胞毒性。 这是吡咯并[3,2-d]嘧啶衍生物作为生物合成产物的分离和表征的第一份报告。
-
公开(公告)号：US06841530B2
公开(公告)日：2005-01-11
申请号：US09949947
申请日：2001-09-10
IPC分类号： A61K38/00 , A61P31/04 , A61P31/10 , A61P31/14 , A61P31/20 , A61P35/00 , A61P37/06 , C07K5/027 , C07K5/12 , C07K11/00 , C07K11/02 , A61K37/00
摘要： Disclosed are semi-synthetic methods for the preparation of Didemnin Analogs. The compounds of this type are illustrated in Formula (I).
摘要翻译： 公开了用于制备Didemnin类似物的半合成方法。 这种化合物在式（I）中示出。
-
公开(公告)号：US06800661B1
公开(公告)日：2004-10-05
申请号：US09386724
申请日：1999-08-31
申请人： Kenneth L. Rinehart , Robert A. Warwick , Jesus Avila , Nancy L. Fregeau Gallagher , Dolores Garcia Gravalos , Glynn T. Faircloth
发明人： Kenneth L. Rinehart , Robert A. Warwick , Jesus Avila , Nancy L. Fregeau Gallagher , Dolores Garcia Gravalos , Glynn T. Faircloth
IPC分类号： A61V3113
CPC分类号： C07C215/08 , A61K35/618 , C07B2200/07
摘要： Investigation of the activity of extracts of the clam Spisula polynyma has led to antitumour long-chain, straight-chain alkane or alkene compounds which have a 2-amino group and a 3-hydroxy group.
摘要翻译： 对蛤蜊提取物的活性的研究Spisula polynyma已经导致具有2-氨基和3-羟基的抗肿瘤长链，直链烷烃或烯烃化合物。
-
公开(公告)号：US5654426A
公开(公告)日：1997-08-05
申请号：US483182
申请日：1995-06-07
申请人： Kenneth L. Rinehart , Ryuichi Sakai
发明人： Kenneth L. Rinehart , Ryuichi Sakai
IPC分类号： C07D513/22 , C07D515/22
CPC分类号： C07D513/22
摘要： Ecteinascidins (Et's), isolated from the Caribbean tunicate Ecteinascidia turbinata, protect mice in vivo against P388 lymphoma, B16 melanoma, M5076 ovarian sarcoma, Lewis lung carcinoma, and the LX-1 human lung and MX-1 human mammary carcinoma zenografts.
摘要翻译： 从加勒比海带分离的Ecteinascidia（Et），保护小鼠体内抗P388淋巴瘤，B16黑素瘤，M5076卵巢肉瘤，Lewis肺癌和LX-1人肺和MX-1人乳腺癌移植瘤。
-
公开(公告)号：US5294603A
公开(公告)日：1994-03-15
申请号：US837803
申请日：1992-02-18
申请人： Kenneth L. Rinehart
发明人： Kenneth L. Rinehart
CPC分类号： C07K11/00
摘要： This invention is directed to didemnin derivatives, including N-acyl congeners of didemnin A (DA); several DDB-type analogues of DA in which either pyruvic acid has been replaced (with phenylpyruvic acid or alphaketobutyric acid) or proline at position 8 has been replaced [with L-azetidine-2-carboxylic acid (AZT), L-pipecolic acid (Pip), 1-amino-1-carboxylic cyclopentane (acc.sup.5), D-Pro or sarcosine (sar); and other cyclic depsipeptides related to the didemnins, which were isolated from a relatively polar extract of the tunicate T. solidum; namely the didemnins--X [(R)-3-hydroxy-decanoyl-(Gln).sub.3 -Lac-Pro didemnin A]; Y [(R)-3-hydroxy-decanoyl-(Gln).sub.4 -Lac-Pro didemnin A]; M (pGlu-Gln-Lac-Pro-didemnin A); N ([Tyr.sup.5 ] didemnin B); nordidemnin N ([Tyr.sup.5 ] nordidemnin B); and epididemnin A ([2S,4R-Hip.sup.2 ] didemnin A).
摘要翻译： 本发明涉及去甲肾上腺素衍生物，包括去甲孕酮A（DA）的N-酰基同系物; 已经替换了其中丙氨酸被替换的几种DDB类似物（苯基丙酮酸或吖丁啶酸）或第8位的脯氨酸已经被替换（用L-氮杂环丁烷-2-羧酸（AZT），L-哌啶酸（ Pip），1-氨基-1-羧基环戊烷（acc5），D-Pro或肌氨酸（sar）;以及与被除虫菊素相关的其它环状缩酚酸肽，其从所述隐孢子虫的相对极性提取物中分离;即 （（R）-3-羟基 - 癸酰基 - （Gln）3-Lac-Pro didemnin A）; Y（（R）-3-羟基 - 癸酰基 - （Gln）4-Lac-Pro didemnin A）; M（pGlu-Gln-Lac-Pro-didemnin A）; N（（Tyr5）didemnin B）; Nordidemn N（（Tyr5）nordidemnin B））和附睾素A（（2S，4R-Hip2）didemnin A）。
-
公开(公告)号：US5137870A
公开(公告)日：1992-08-11
申请号：US482372
申请日：1990-02-20
申请人： Kenneth L. Rinehart
发明人： Kenneth L. Rinehart
IPC分类号： C07K11/00
CPC分类号： C07K11/00
摘要： Novel antibiotics didemnins A, B and C (didemnins), and nordidemnins A, B and C (nordidemnins) which can be obtained from a marine organism. These antibiotics are active against a variety of DNA and RNA viruses; thus, they can be used in various environments to control or eradicate these viruses. Further, these antibiotics can be used to treat animals and humans hosting a neoplastic disease.
摘要翻译： 新型抗生素可以从海洋生物体中获得A，B和C（didemnins）和nordidemnins A，B和C（nordidemnins）。 这些抗生素对多种DNA和RNA病毒具有活性; 因此，它们可以用于各种环境以控制或根除这些病毒。 此外，这些抗生素可用于治疗携带肿瘤性疾病的动物和人类。
-
公开(公告)号：USRE39887E1
公开(公告)日：2007-10-16
申请号：US11145507
申请日：2005-06-02
CPC分类号： C07K11/02 , A61K38/00 , Y10S530/857 , Y10S930/27
摘要： Dehydrodidemnin B with useful biological activity has formula (1). It can be isolated from natural sources or synthesized, and it forms active derivatives.
摘要翻译： 具有有用生物活性的脱氢阿维菌素B具有式（1）。 它可以从天然来源或合成的中分离出来，形成活性衍生物。
-
公开(公告)号：US06855337B1
公开(公告)日：2005-02-15
申请号：US10232880
申请日：2002-08-30
摘要： A bear derived isolate found in denning black bears or black bears from which food has been withheld for at least two weeks when injected into another mammal produces reduced heart rate, reduced respiratory rate, reduced temperature, and a wakeful tranquility not unlike the phenomena of the denning black bear. The isolate is taken from either the serum or urine of such denning bear. The method of the invention involves the steps of fractionating the serum or urine of a denning black bear to produce fractions of varying potency.
摘要翻译： 在注射到另一种哺乳动物时，至少两周内禁食黑色熊或黑熊的熊衍生的分离物发现降低的心率，降低的呼吸频率，降低的温度和醒觉的宁静与不同于 诋毁黑熊 分离物取自这种剔骨的血清或尿液。 本发明的方法包括分离脱色黑熊的血清或尿液以产生不同效力的级分的步骤。
-
公开(公告)号：US6124293A
公开(公告)日：2000-09-26
申请号：US286242
申请日：1999-04-05
IPC分类号： C07D497/22 , A61K31/47 , A61K31/495 , A61K31/4995 , A61K35/56 , A61P35/00 , A61P35/02 , C07D225/04 , C07D515/22 , C07D519/00
CPC分类号： C07D515/22 , C07D519/00
摘要： The present invention is directed to several newly prepared semi-synthetic ecteinascidin (Et) species, designated herein as Et 757, Boc-Et 729, Iso-Et 743, Et 875, and Et 1560. The physical properties of these compounds, their preparation and bioactivities are also reported. ##STR1##
摘要翻译： 本发明涉及几种新制备的半合成的海e素（Et）物质，本文命名为Et 757，Boc-Et 729，Iso-Et 743，Et 875和Et 1560.这些化合物的物理性质，它们的制备 还报道了生物活性。
-
-
-
-
-
-
-
-
-
搜索结果
37 条记录 (耗时 0.031 秒)
