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1.发明授权公开(公告)号：US06796963B2
公开(公告)日：2004-09-28
申请号：US10000786
申请日：2001-10-23
IPC分类号： A61M500
CPC分类号： A61M25/0612 , A61B2090/062 , A61M25/0084 , A61M2025/0008 , A61M2025/0089 , A61M2202/0413 , A61M2205/75 , A61M2202/0021
摘要： The invention tissue injection catheters are designed to facilitate injection of a therapeutic or diagnostic agent to an interior body cavity, especially the myocardium or epicardium of the heart with precisely controlled depth penetration. The invention injection catheters, which include mechanisms for precisely controlling the length of needle tip exposed for tissue penetration, are designed to be used in an assemblage with a sterile container and delivery actuator for reinjection of autologous cell-containing fluids, such as autologous bone marrow aspirate. In preferred embodiments, the assemblage is designed to be hand-held. When used in such an assemblage, the invention catheters are particularly useful as a gene delivery device to effect angiogenesis of ischemic areas of the heart.
摘要翻译： 本发明的组织注射导管被设计成便于将治疗剂或诊断剂注射到内部体腔，特别是具有精确控制的深度穿透的心脏的心肌或心外膜。 本发明的注射导管包括用于精确控制暴露于组织穿透的针尖的长度的机构，被设计成与无菌容器和用于再注射含自体细胞的流体例如自体骨髓的输送致动器组合使用 吸气 在优选实施例中，组合被设计为手持式。 当用于这种组合时，本发明的导管特别可用作用于实现心脏缺血区域血管生成的基因递送装置。
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公开(公告)号：US06796957B2
公开(公告)日：2004-09-28
申请号：US10004525
申请日：2001-10-23
IPC分类号： A61M3100
CPC分类号： A61M25/0084 , A61B2090/062 , A61M2025/0089 , A61M2202/0413 , A61M2205/75 , Y10S977/916 , A61M2202/0021
摘要： The invention provides systems containing a sterile container for aspiration, filtering, treating and reinjection into a subject of a bodily fluid in a sterile environment. The systems are particularly designed to facilitate transfection of cells within the sterile container by gene therapy molecules and reinjection of the transfected cells into the donor at controlled depth in precisely controlled volumes such as is useful for revascularization of ischemic cardiac tissue. For injection, a pressure actuator, preferably hand-held, applies force to liquids held within the sterile container in precisely controlled increments, thereby expressing liquids through a hollow needle or injection catheter in precisely controlled microvolumes. The invention systems include a hand-held injection device with audible cues that correspond to an operator-selected injection volume and/or audible cues that correspond to needle penetration depth selected by the operator.
摘要翻译： 本发明提供了包含用于在无菌环境中吸入，过滤，处理和再注入体液的受试者的无菌容器的系统。 该系统特别设计用于通过基因治疗分子促进无菌容器内的细胞的转染，并以受精的控制体积（例如对于缺血性心脏组织的血运重建有用）将被转染的细胞重新注入受控深度的供体。 对于注射，优选手持式压力致动器以精确控制的增量对保持在无菌容器内的液体施加力，从而通过中空针或注射导管在精确控制的微量体积中表达液体。 本发明系统包括手持式注射装置，其具有对应于操作者选择的注射体积和/或对应于由操作者选择的穿刺深度的可听到的线索的可听到的提示。
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