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公开(公告)号：US20070129338A1
公开(公告)日：2007-06-07
申请号：US11620260
申请日：2007-01-05
申请人： Kevin DUFFY , Connie Erickson-Miller , Daniel Eppley , Julian Jenkins , Juan Luengo , Nannan Liu , Alan Price , Antony Shaw , Sophie Visonneau , Kenneth Wiggall
发明人： Kevin DUFFY , Connie Erickson-Miller , Daniel Eppley , Julian Jenkins , Juan Luengo , Nannan Liu , Alan Price , Antony Shaw , Sophie Visonneau , Kenneth Wiggall
IPC分类号： A61K31/655
CPC分类号： C07D403/12 , C07D231/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D417/04 , C07D417/12
摘要： Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
摘要翻译： 发明的是非肽TPO模拟物。 还发明了用于制备本发明化合物的新方法和中间体。 还发明了一种在有需要的哺乳动物（包括人）中治疗血小板减少症的方法，其包括向所述哺乳动物施用有效量的选择的羟基-1-偶氮苯衍生物。
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公开(公告)号：US20080090996A1
公开(公告)日：2008-04-17
申请号：US11650688
申请日：2007-01-08
申请人： Kevin Duffy , Connie Erickson-Miller , Daniel Eppley , Julian Jenkins , Juan Luengo , Nannan Liu , Alan Price , Antony Shaw , Sophie Visonneau , Kenneth Wiggall
发明人： Kevin Duffy , Connie Erickson-Miller , Daniel Eppley , Julian Jenkins , Juan Luengo , Nannan Liu , Alan Price , Antony Shaw , Sophie Visonneau , Kenneth Wiggall
IPC分类号： C09B29/00
CPC分类号： C07D403/12 , C07D231/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D417/04 , C07D417/12
摘要： Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
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公开(公告)号：US20080090787A1
公开(公告)日：2008-04-17
申请号：US11650838
申请日：2007-01-08
申请人： Kevin Duffy , Connie Erickson-Miller , Daniel Eppley , Julian Jenkins , Juan Luengo , Nannan Liu , Alan Price , Antony Shaw , Sophie Visonneau , Kenneth Wiggall
发明人： Kevin Duffy , Connie Erickson-Miller , Daniel Eppley , Julian Jenkins , Juan Luengo , Nannan Liu , Alan Price , Antony Shaw , Sophie Visonneau , Kenneth Wiggall
IPC分类号： A61K31/655 , A61P7/00 , C09B29/00
CPC分类号： C07D403/12 , C07D231/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D417/04 , C07D417/12
摘要： Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
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公开(公告)号：US07332481B2
公开(公告)日：2008-02-19
申请号：US11620260
申请日：2007-01-05
申请人： Kevin J. Duffy , Connie Erickson-Miller , Julian Jenkins , Juan Luengo , Alan T. Price , Antony N. Shaw , Sophie Visonneau , Kenneth Wiggall
发明人： Kevin J. Duffy , Connie Erickson-Miller , Julian Jenkins , Juan Luengo , Alan T. Price , Antony N. Shaw , Sophie Visonneau , Kenneth Wiggall
IPC分类号： A61K31/4152 , A61K31/655
CPC分类号： C07D403/12 , C07D231/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D417/04 , C07D417/12
摘要： Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
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公开(公告)号：US20090176746A1
公开(公告)日：2009-07-09
申请号：US12141422
申请日：2008-06-18
申请人： Kevin J Duffy , Connie Erickson-Miller , Daniel F. Eppley , Julian Jenkins , Juan I. Luengo , Nannan Liu , Alan T. Price , Antony N. Shaw , Sophie Visonneau , Kenneth Wiggall
发明人： Kevin J Duffy , Connie Erickson-Miller , Daniel F. Eppley , Julian Jenkins , Juan I. Luengo , Nannan Liu , Alan T. Price , Antony N. Shaw , Sophie Visonneau , Kenneth Wiggall
IPC分类号： A61K31/655 , A61P35/02
CPC分类号： C07D403/12 , C07D231/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D417/04 , C07D417/12
摘要： Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
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公开(公告)号：US20080214640A1
公开(公告)日：2008-09-04
申请号：US11650651
申请日：2007-01-08
申请人： Kevin J. Duffy , Connie Erickson-Miller , Daniel F. Eppley , Julian Jenkins , Juan I. Luengo , Nannan Liu , Alan T. Price , Antony N. Shaw , Sophie Visonneau , Kenneth Wiggall
发明人： Kevin J. Duffy , Connie Erickson-Miller , Daniel F. Eppley , Julian Jenkins , Juan I. Luengo , Nannan Liu , Alan T. Price , Antony N. Shaw , Sophie Visonneau , Kenneth Wiggall
IPC分类号： A61K31/4152 , C07D231/46 , A61P7/02
CPC分类号： C07D403/12 , C07D231/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D417/04 , C07D417/12
摘要： Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
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公开(公告)号：US20130078213A1
公开(公告)日：2013-03-28
申请号：US13593739
申请日：2012-08-24
申请人： Kevin J. Duffy , Connie Erickson-Miller , Daniel F. Eppley , Julian Jenkins , Juan I. Luengo , Nannan Liu , Alan T. Price , Antony N. Shaw , Sophie Visonneau , Kenneth Wiggall
发明人： Kevin J. Duffy , Connie Erickson-Miller , Daniel F. Eppley , Julian Jenkins , Juan I. Luengo , Nannan Liu , Alan T. Price , Antony N. Shaw , Sophie Visonneau , Kenneth Wiggall
IPC分类号： C07D403/12 , A61K45/06 , A61K31/4155 , C07D231/46 , A61K31/415
CPC分类号： C07D231/46 , A61K31/415 , A61K31/4155 , A61K31/655 , A61K45/06 , C07D231/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D417/04 , C07D417/12
摘要： Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
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公开(公告)号：US20090176973A1
公开(公告)日：2009-07-09
申请号：US12141379
申请日：2008-06-18
申请人： Kevin J. Duffy , Connie Erickson-Miller , Daniel F. Eppley , Julian Jenkins , Juan I. Luengo , Nannan Liu , Alan T. Price , Antony N. Shaw , Sophie Visonneau , Kenneth Wiggall
发明人： Kevin J. Duffy , Connie Erickson-Miller , Daniel F. Eppley , Julian Jenkins , Juan I. Luengo , Nannan Liu , Alan T. Price , Antony N. Shaw , Sophie Visonneau , Kenneth Wiggall
IPC分类号： C09B27/00 , C07C59/42 , C07D231/38
CPC分类号： C07D403/12 , C07D231/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D417/04 , C07D417/12
摘要： Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
摘要翻译： 发明的是非肽TPO模拟物。 还发明了用于制备本发明化合物的新方法和中间体。 还发明了一种在有需要的哺乳动物（包括人）中治疗血小板减少症的方法，其包括向所述哺乳动物施用有效量的选择的羟基-1-偶氮苯衍生物。
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公开(公告)号：US20070179192A1
公开(公告)日：2007-08-02
申请号：US11558071
申请日：2006-11-09
IPC分类号： A61K31/416 , A61K38/18 , A61K38/19 , A61K38/20 , C07D403/02
CPC分类号： C07D403/12 , C07D231/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D417/04 , C07D417/12
摘要： Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
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公开(公告)号：US20090155203A1
公开(公告)日：2009-06-18
申请号：US12141397
申请日：2008-06-18
申请人： Kevin J. Duffy , Connie Erickson-Miller , Daniel F. Eppley , Julian Jenkins , Juan I. Luengo , Nannan Liu , Alan T. Price , Antony N. Shaw , Sophie Visonneau , Kenneth Wiggal
发明人： Kevin J. Duffy , Connie Erickson-Miller , Daniel F. Eppley , Julian Jenkins , Juan I. Luengo , Nannan Liu , Alan T. Price , Antony N. Shaw , Sophie Visonneau , Kenneth Wiggal
IPC分类号： A61K31/655 , A61K38/17 , A61K38/19 , A61K38/20
CPC分类号： C07D403/12 , C07D231/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D417/04 , C07D417/12
摘要： Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
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