摘要:
Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
摘要:
Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
摘要:
Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
摘要:
A split inner ring of a bearing assembly comprises first and second rings, a plurality of holes, a circumferential annulus and a lubrication system. The first and second rings are configured to mate axially at inside side surfaces to define an inner raceway formed on an outer surface of the rings. The plurality of holes are circumferentially spaced and extend from an outside side surface to an inside side surface of the first ring. The circumferential annulus is formed on the inside side surface of the first ring, between the inner raceway and an inner surface of the first ring, and intersects the plurality of holes. The lubrication system connects the circumferential annulus to the outer surface of the first ring and the second ring. The lubrication system comprises circumferentially spaced slots in the first ring, or axial holes fluidly coupled with radial holes in the second ring.
摘要:
Provided are compounds of Formula V and pharmaceutically acceptable salts thereof which may be useful for the treatment of cancer or other proliferative disorders.
摘要:
This invention relates to newly identified compounds for inhibiting hYAK3 proteins and methods for treating diseases associated with hYAK3 activity.
摘要:
A method of operating an internal combustion engine including at least one cylinder and a piston slidable in the cylinder is provided. In at least one embodiment, the method includes: supplying a mixture of pressurized air and recirculated exhaust gas from an intake manifold to an air intake port of a combustion chamber in the cylinder; operating an air intake valve to open the air intake port to allow the pressurized air and exhaust gas mixture to flow between the combustion chamber and the intake manifold during a portion of a compression stroke of the piston; and operably controlling a fuel supply system to inject fuel into the combustion chamber via a common rail fuel injector.
摘要:
An engine and a method of operating an internal combustion engine is provided. The method comprises supplying a pressurized air from an intake manifold to an air intake port of a combustion chamber in the cylinder, operating an air intake valve to open the air intake port to allow the pressurized air and exhaust gas mixture to flow between the combustion chamber and the intake manifold during a portion of a compression stroke of the piston, and operating the engine in an HCCI combustion mode. In at least some embodiments, a mixture of pressurized air and recirculated exhaust gas is supplied from an intake manifold to an air intake port of a combustion chamber in the cylinder. In some embodiments, the method further comprises causing an exhaust stream of an engine to contact a NOx adsorber.
摘要:
Engines and methods of controlling an engine may involve at least one fluid actuators associated with one or more engine intake and/or exhaust valves. Timing of valve closing/opening and use of an air supply system may enable engine operation according to a Miller cycle.
摘要:
A method of operating an engine system should produce relatively low concentrations of various emissions without compromising a desired power output of the system. In order to operate an engine system of the present disclosure, a predetermined total amount of fuel injected into at least one combustion chamber is apportioned into at least a first amount and a second amount of fuel. The first amount of fuel is injected into the at least one combustion chamber during non-auto ignition conditions. The second amount of fuel is injected into the at least one combustion chamber during auto-ignition conditions. When the engine system is in a mid-low engine load range, the second amount of fuel is one of equal to or less than 15% of the predetermined total amount of fuel. When the engine system is in a high engine load range, the second amount of fuel is greater than 15% of the predetermined total amount of fuel.