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    Expandable Member Formed Of A Fibrous Matrix Having Hydrogel Polymer For Intraluminal Drug Delivery
    1.
    发明申请
    Expandable Member Formed Of A Fibrous Matrix Having Hydrogel Polymer For Intraluminal Drug Delivery 有权
    具有用于腔内药物递送的水凝胶聚合物的纤维基质的可膨胀构件

    公开(公告)号：US20100076377A1

    公开(公告)日：2010-03-25

    申请号：US12238026

    申请日：2008-09-25

    申请人： Kevin J. Ehrenreich ,  Richard R. Newhauser ,  Randolf von Oepen ,  John Stankus

    发明人： Kevin J. Ehrenreich ,  Richard R. Newhauser ,  Randolf von Oepen ,  John Stankus

    IPC分类号： A61M29/00 ,  A61M31/00

    CPC分类号： A61M25/1029 ,  A61L29/085 ,  A61L29/16 ,  A61L2300/606 ,  A61M25/104 ,  A61M2025/1031 ,  A61M2025/105 ,  A61M2025/1075 ,  A61M2025/1088

    摘要： An intraluminal catheter device having an expandable member formed of a matrix of fiber elements, the expandable member including a hydrogel polymer having a therapeutic agent incorporated therein. The hydrogel polymer can be coated on the fiber elements in a co-axial configuration. The fiber elements may also have a second coating including a protective substance surrounding the hydrogel polymer having a therapeutic agent therein. The matrix of fiber elements can be formed by electrospinning. A process of delivering a therapeutic agent to a target site includes providing an intraluminal catheter device having an expandable member formed of a matrix of fiber elements, the expandable member including a hydrogel polymer having a therapeutic agent dispersed therein, and advancing the catheter device at a desired treatment site. Once at the desired treatment site, fluid is introduced into the inflation lumen to expand the expandable member from a first profile to a second profile, and the therapeutic agent is released from the hydrogel polymer and delivered to the desired treatment site.

    摘要翻译： 一种管腔内导管装置，其具有由纤维元件基质形成的可膨胀构件，所述可扩张构件包括其中结合有治疗剂的水凝胶聚合物。 水凝胶聚合物可以以同轴构型涂覆在纤维元件上。 纤维元件还可以具有包含围绕水凝胶聚合物的保护性物质的第二涂层，其中具有治疗剂。 纤维元素的基质可以通过静电纺丝形成。 将治疗剂递送到靶位置的过程包括提供具有由纤维元件基质形成的可扩张构件的管腔内导管装置，所述可扩张构件包括其中分散有治疗剂的水凝胶聚合物，并将导管装置推进到 所需治疗部位。 一旦在期望的治疗部位，将流体引入充气腔，以将可膨胀构件从第一轮廓扩张到第二轮廓，并且将治疗剂从水凝胶聚合物释放并递送到所需的治疗部位。

    Expandable Member Formed Of A Fibrous Matrix For Intraluminal Drug Delivery
    2.
    发明申请
    Expandable Member Formed Of A Fibrous Matrix For Intraluminal Drug Delivery 有权
    用于腔内药物递送的纤维基质形成的可膨胀构件

    公开(公告)号：US20100081992A1

    公开(公告)日：2010-04-01

    申请号：US12238627

    申请日：2008-09-26

    申请人： Kevin J. Ehrenreich ,  Richard R. Newhauser ,  Randolf von Oepen ,  John Stankus

    发明人： Kevin J. Ehrenreich ,  Richard R. Newhauser ,  Randolf von Oepen ,  John Stankus

    IPC分类号： A61M25/10

    CPC分类号： A61M25/104 ,  A61L29/16 ,  A61L2300/606 ,  A61M25/10 ,  A61M25/1029 ,  A61M2025/1031 ,  A61M2025/105 ,  A61M2025/1075 ,  D01D5/0076

    摘要： An intraluminal catheter device having an expandable member formed of a matrix of fiber elements with a therapeutic agent incorporated therein. The therapeutic agent can be coated on the fiber elements in a co-axial configuration. The fiber elements may also have a second coating including a protective substance surrounding the therapeutic agent. The matrix of fiber elements can be formed by electrospinning. A process of delivering a therapeutic agent to a target site includes providing an intraluminal catheter device having an expandable member formed of a matrix of fiber elements, the expandable member having a therapeutic agent dispersed therein, and advancing the catheter device at a desired treatment site. Once at the desired treatment site, fluid is introduced into the inflation lumen to expand the expandable member from a first profile to a second profile, and the therapeutic agent is delivered to the desired treatment site.

    摘要翻译： 一种管腔内导管装置，其具有由其中结合有治疗剂的纤维元件基质形成的可扩张构件。 治疗剂可以以同轴构型涂覆在纤维元件上。 纤维元件还可以具有包含围绕治疗剂的保护性物质的第二涂层。 纤维元素的基质可以通过静电纺丝形成。 将治疗剂递送到靶位置的过程包括提供具有由纤维元件基质形成的可扩张构件的管腔内导管装置，所述可扩张构件具有分散在其中的治疗剂，并且将导管装置推进到期望的治​​疗部位。 一旦在所需的治疗部位，将流体引入充气腔，以将可膨胀构件从第一轮廓扩张到第二轮廓，并将治疗剂递送到所需的治疗部位。

    Expandable member formed of a fibrous matrix for intraluminal drug delivery
    3.
    发明授权
    Expandable member formed of a fibrous matrix for intraluminal drug delivery 有权
    由用于管腔内药物递送的纤维基质形成的可膨胀构件

    公开(公告)号：US08076529B2

    公开(公告)日：2011-12-13

    申请号：US12238627

    申请日：2008-09-26

    申请人： Kevin J. Ehrenreich ,  Richard R. Newhauser ,  Randolf von Oepen ,  John Stankus

    发明人： Kevin J. Ehrenreich ,  Richard R. Newhauser ,  Randolf von Oepen ,  John Stankus

    IPC分类号： A61F13/15 ,  A61F13/20 ,  A61M31/00 ,  A61M37/00 ,  A61M29/00

    CPC分类号： A61M25/104 ,  A61L29/16 ,  A61L2300/606 ,  A61M25/10 ,  A61M25/1029 ,  A61M2025/1031 ,  A61M2025/105 ,  A61M2025/1075 ,  D01D5/0076

    摘要： An intraluminal catheter device having an expandable member formed of a matrix of fiber elements with a therapeutic agent incorporated therein. The therapeutic agent can be coated on the fiber elements in a co-axial configuration. The fiber elements may also have a second coating including a protective substance surrounding the therapeutic agent. The matrix of fiber elements can be formed by electrospinning. A process of delivering a therapeutic agent to a target site includes providing an intraluminal catheter device having an expandable member formed of a matrix of fiber elements, the expandable member having a therapeutic agent dispersed therein, and advancing the catheter device at a desired treatment site. Once at the desired treatment site, fluid is introduced into the inflation lumen to expand the expandable member from a first profile to a second profile, and the therapeutic agent is delivered to the desired treatment site.

    摘要翻译： 一种管腔内导管装置，其具有由其中结合有治疗剂的纤维元件基质形成的可扩张构件。 治疗剂可以以同轴构型涂覆在纤维元件上。 纤维元件还可以具有包含围绕治疗剂的保护性物质的第二涂层。 纤维元素的基质可以通过静电纺丝形成。 将治疗剂递送到靶位置的过程包括提供具有由纤维元件基质形成的可扩张构件的管腔内导管装置，所述可扩张构件具有分散在其中的治疗剂，并且将导管装置推进到期望的治​​疗部位。 一旦在所需的治疗部位，将流体引入充气腔，以将可膨胀构件从第一轮廓扩张到第二轮廓，并将治疗剂递送到所需的治疗部位。

    Expandable member formed of a fibrous matrix having hydrogel polymer for intraluminal drug delivery
    4.
    发明授权
    Expandable member formed of a fibrous matrix having hydrogel polymer for intraluminal drug delivery 有权
    由具有用于管腔内药物递送的水凝胶聚合物的纤维基质形成的可膨胀构件

    公开(公告)号：US08049061B2

    公开(公告)日：2011-11-01

    申请号：US12238026

    申请日：2008-09-25

    申请人： Kevin J. Ehrenreich ,  Richard R. Newhauser ,  Randolf von Oepen ,  John Stankus

    发明人： Kevin J. Ehrenreich ,  Richard R. Newhauser ,  Randolf von Oepen ,  John Stankus

    IPC分类号： A61F13/15 ,  A61F13/20 ,  A61M31/00 ,  A61M37/00 ,  A61M29/00

    CPC分类号： A61M25/1029 ,  A61L29/085 ,  A61L29/16 ,  A61L2300/606 ,  A61M25/104 ,  A61M2025/1031 ,  A61M2025/105 ,  A61M2025/1075 ,  A61M2025/1088

    摘要： An intraluminal catheter device having an expandable member formed of a matrix of fiber elements, the expandable member including a hydrogel polymer having a therapeutic agent incorporated therein. The hydrogel polymer can be coated on the fiber elements in a co-axial configuration. The fiber elements may also have a second coating including a protective substance surrounding the hydrogel polymer having a therapeutic agent therein. The matrix of fiber elements can be formed by electrospinning. A process of delivering a therapeutic agent to a target site includes providing an intraluminal catheter device having an expandable member formed of a matrix of fiber elements, the expandable member including a hydrogel polymer having a therapeutic agent dispersed therein, and advancing the catheter device at a desired treatment site. Once at the desired treatment site, fluid is introduced into the inflation lumen to expand the expandable member from a first profile to a second profile, and the therapeutic agent is released from the hydrogel polymer and delivered to the desired treatment site.

    摘要翻译： 一种管腔内导管装置，其具有由纤维元件基质形成的可膨胀构件，所述可扩张构件包括其中结合有治疗剂的水凝胶聚合物。 水凝胶聚合物可以以同轴构型涂覆在纤维元件上。 纤维元件还可以具有包含围绕水凝胶聚合物的保护性物质的第二涂层，其中具有治疗剂。 纤维元素的基质可以通过静电纺丝形成。 将治疗剂递送到靶位置的过程包括提供具有由纤维元件的基质形成的可扩张构件的管腔内导管装置，所述可扩张构件包括其中分散有治疗剂的水凝胶聚合物，并将导管装置推进到 所需治疗部位。 一旦在期望的治疗部位，将流体引入充气腔，以将可膨胀构件从第一轮廓扩张到第二轮廓，并且将治疗剂从水凝胶聚合物释放并递送到所需的治疗部位。