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公开(公告)号：US20080161353A1
公开(公告)日：2008-07-03
申请号：US11901941
申请日：2007-09-19
IPC分类号： A61K31/4725 , A61P25/00 , A61K31/47
CPC分类号： C07D215/48 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K45/06 , C07D215/00 , C07D215/24 , C07D215/26 , C07D215/28 , C07D215/38 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/04 , C07D417/12 , C07D417/14 , Y02A50/411 , A61K2300/00
摘要： The present invention describes a method for the treatment of a neurological condition in a subject which comprises administering to a subject in need thereof a therapeutically effect amount of a compound of the formula or pharmaceutically acceptable salts, hydrates, or solvates thereof.
摘要翻译： 本发明描述了治疗受试者神经学病症的方法，其包括向有需要的受试者施用治疗有效量的下式化合物或其药学上可接受的盐，水合物或溶剂化物。
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公开(公告)号：US07619091B2
公开(公告)日：2009-11-17
申请号：US10521902
申请日：2003-07-16
IPC分类号： C07D215/38
CPC分类号： C07D215/48 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K45/06 , C07D215/00 , C07D215/24 , C07D215/26 , C07D215/28 , C07D215/38 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/04 , C07D417/12 , C07D417/14 , Y02A50/411 , A61K2300/00
摘要： The present invention relates to a method for the treatment, amelioration and/or prophylaxis of a neurological condition, in particular neurodegenerative disorders which comprises the administration of an effective amount of a compound of formula (I): to a subject in need thereof. The present invention also relates to a compound of formula (II) and processes for its preparation.
摘要翻译： 本发明涉及一种治疗，改善和/或预防神经系统疾病，特别是神经变性疾病的方法，其包括向有需要的受试者施用有效量的式（I）化合物。 本发明还涉及式（II）的化合物及其制备方法。
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公开(公告)号：US08975278B2
公开(公告)日：2015-03-10
申请号：US11901941
申请日：2007-09-19
IPC分类号： A01N43/42 , A61K31/47 , C07D215/00 , C07D215/38 , A61K31/4709 , A61K31/4725 , A61K45/06 , C07D215/26 , C07D215/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/04 , C07D417/12 , C07D417/14
CPC分类号： C07D215/48 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K45/06 , C07D215/00 , C07D215/24 , C07D215/26 , C07D215/28 , C07D215/38 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/04 , C07D417/12 , C07D417/14 , Y02A50/411 , A61K2300/00
摘要： The present invention describes a method for the treatment of a neurological condition in a subject which comprises administering to a subject in need thereof a therapeutically effect amount of a compound of the formula or pharmaceutically acceptable salts, hydrates, or solvates thereof.
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公开(公告)号：US07692011B2
公开(公告)日：2010-04-06
申请号：US10530137
申请日：2003-10-03
申请人： Kevin Jeffrey Barnham , Elisabeth Colette Louise Gautier , Gaik Beng Kok , Brenda Kwan Yi Leung
发明人： Kevin Jeffrey Barnham , Elisabeth Colette Louise Gautier , Gaik Beng Kok , Brenda Kwan Yi Leung
IPC分类号： C07D239/70
CPC分类号： A61K31/4375 , A61K31/435 , A61K31/436 , A61K31/47 , A61K31/473 , A61K31/4745 , A61K31/495 , A61K31/498 , A61K31/50 , A61K31/5025 , A61K31/517 , A61K31/519 , C07C233/54 , C07D239/88 , C07D241/42 , C07D471/04
摘要： The present invention relates to neurologically active 8-hydroxy- or 8-mercapto-quinazolinones. Also disclosed are processes for the preparation of these compounds and their use as pharmaceutical or veterinary agents, in particular for the treatment of neurological conditions, more specifically neurodegenerative conditions, such as Alzheimer's disease.
摘要翻译： 本发明涉及神经活性8-羟基或8-巯基喹唑啉酮。 还公开了用于制备这些化合物的方法及其作为药物或兽药的用途，特别是用于治疗神经病症，更具体地说是神经变性病症如阿尔茨海默氏病。
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公开(公告)号：US20100160346A1
公开(公告)日：2010-06-24
申请号：US12717631
申请日：2010-03-04
申请人： Kevin Jeffrey Barnham , Elisabeth Colette Louise Gautier , Gaik Beng Kok , Brenda Kwan Yi Leung
发明人： Kevin Jeffrey Barnham , Elisabeth Colette Louise Gautier , Gaik Beng Kok , Brenda Kwan Yi Leung
IPC分类号： A61K31/519 , C07D487/04
CPC分类号： A61K31/4375 , A61K31/435 , A61K31/436 , A61K31/47 , A61K31/473 , A61K31/4745 , A61K31/495 , A61K31/498 , A61K31/50 , A61K31/5025 , A61K31/517 , A61K31/519 , C07C233/54 , C07D239/88 , C07D241/42 , C07D471/04
摘要： The present invention relates to neurologically-active compounds, processes for their preparation and their use as pharmaceutical or veterinary agents, in particular for the treatment of neurological conditions, more specifically neurodegenerative conditions such as Alzheimer's disease.
摘要翻译： 本发明涉及神经活性化合物，其制备方法及其作为药物或兽药的用途，特别是用于治疗神经病症，更具体地说是神经变性疾病如阿尔茨海默病。
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公开(公告)号：US20080119470A1
公开(公告)日：2008-05-22
申请号：US11547056
申请日：2005-04-01
IPC分类号： A61K31/5377 , C07D403/06 , C07D413/04 , A61P25/28 , A61K31/517
CPC分类号： C07D471/04 , C07C51/367 , C07C227/04 , C07C229/64 , C07D239/90 , C07D239/91 , C07D239/92 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/10 , C07D417/14 , C07C65/03
摘要： Neurologically-active heterocyclic compounds comprising two fused 6-membered rings with nitrogen atoms at positions 1 and 3, a carboxy group at position 4, and a hydroxy group at position 8, with one ring being aromatic. Processes for the preparation of these compounds and their use as pharmaceutical or veterinary agents, in particular for the treatment of neurological conditions, and more specifically neurodegenerative conditions such as Alzheimer's disease.
摘要翻译： 包含位置1和3上具有氮原子的2个稠合的6元环，4位羧基和8位的羟基，其中一个环是芳香族的神经学活性杂环化合物。 用于制备这些化合物的方法及其作为药物或兽药的用途，特别是用于治疗神经病症，尤其是用于治疗神经变性疾病如阿尔茨海默氏病。
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公开(公告)号：US08084459B2
公开(公告)日：2011-12-27
申请号：US11547056
申请日：2005-04-01
IPC分类号： A61K31/517
CPC分类号： C07D471/04 , C07C51/367 , C07C227/04 , C07C229/64 , C07D239/90 , C07D239/91 , C07D239/92 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/10 , C07D417/14 , C07C65/03
摘要： Compounds of the formula or salts, tautomers or isomers thereof, are useful for treating neurological conditions, especially neurodegenerative disorders, such as Alzheimer's disease.
摘要翻译： 式或其盐，互变异构体或其异构体的化合物可用于治疗神经病症，特别是神经变性疾病如阿尔茨海默病。
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公开(公告)号：US08163760B2
公开(公告)日：2012-04-24
申请号：US12306202
申请日：2007-06-22
IPC分类号： A01N43/54 , A01N43/90 , A01N43/42 , A61K31/517 , A61K31/519 , A61K31/44
CPC分类号： A61K31/47 , A61K31/517
摘要： The present invention relates generally to therapeutic agents, formulations comprising them and their use in the treatment, amelioration and/or prophylaxis of glioma brain tumors and related conditions. The therapeutic agent comprises two fused 6-membered rings with at least a nitrogen at position 1 and a hydroxyl at position 8.
摘要翻译： 本发明一般涉及治疗剂，包含它们的制剂及其在治疗，改善和/或预防胶质瘤脑肿瘤和相关病症中的用途。 治疗剂包含两个稠合的6元环，其中位于第1位的至少有氮和位置8处的羟基。
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公开(公告)号：US20100144693A1
公开(公告)日：2010-06-10
申请号：US12297165
申请日：2007-04-13
申请人： Ashley Bush , Colin Louis Masters , Penelope Jane Huggins , Jack Gordon Parsons , Gaik Beng Kok , Vijaya Kenche , Mariana El Sous
发明人： Ashley Bush , Colin Louis Masters , Penelope Jane Huggins , Jack Gordon Parsons , Gaik Beng Kok , Vijaya Kenche , Mariana El Sous
IPC分类号： A61K31/555 , A61K31/5025 , A61K31/498 , A61K31/519 , A61K31/517 , A61K31/4745 , A61K31/4375 , A61K31/47 , A61K31/4709 , A61K31/444 , C07D471/04 , A61P17/02
CPC分类号： C07D471/04 , A61K31/4375 , A61K31/4412 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/517
摘要： The present invention relates generally to the field of treatment and prophylaxis of retinal degenerative diseases. More particularly, the present invention contemplates a method for preventing, reducing the risk of development of, or otherwise treating or ameliorating the symptoms of, age-related macular degeneration (AMD) or related retinal conditions in mammals and in particular humans. The present invention further provides therapeutic compositions enabling dose-dependent or dose-specific administration of agents useful in the treatment and prophylaxis of age-related macular degeneration or related retinal degenerative conditions.
摘要翻译： 本发明一般涉及治疗和预防视网膜退行性疾病的领域。 更具体地，本发明考虑了一种用于预防，降低发展或以其他方式治疗或改善哺乳动物，特别是人类中年龄相关性黄斑变性（AMD）或相关视网膜病症的症状的风险的方法。 本发明进一步提供能够使用剂量依赖性或剂量特异性施用可用于治疗和预防年龄相关性黄斑变性或相关视网膜退行性病症的药剂的治疗组合物。
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公开(公告)号：US20100069393A1
公开(公告)日：2010-03-18
申请号：US12306202
申请日：2007-06-22
IPC分类号： A61K31/495 , A61K31/47 , A61K31/517 , A61K31/519 , A61K31/4375 , C07D239/70 , C07D239/72 , C07D471/00
CPC分类号： A61K31/47 , A61K31/517
摘要： The present invention relates generally to therapeutic agents, formulations comprising them and their use in the treatment, amelioration and/or prophylaxis of glioma brain tumours and related conditions. The therapeutic agent comprises two fused 6-membered rings with at least a nitrogen at position 1 and a hydroxyl at position 8.
摘要翻译： 本发明一般涉及治疗剂，包含它们的制剂及其在治疗，改善和/或预防胶质瘤脑肿瘤和相关病症中的用途。 治疗剂包含两个稠合的6元环，其中位于第1位的至少有氮和位置8处的羟基。
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