公开(公告)号：US06511993B1

公开(公告)日：2003-01-28

申请号：US09586623

申请日：2000-06-02

申请人： Kevin Neil Dack ,  Michael Jonathan Fray ,  Gavin Alistair Whitlock ,  Mark Llewellyn Lewis ,  Nicholas Murray Thomson

发明人： Kevin Neil Dack ,  Michael Jonathan Fray ,  Gavin Alistair Whitlock ,  Mark Llewellyn Lewis ,  Nicholas Murray Thomson

IPC分类号： A61K314545

CPC分类号： C07D401/10 ,  C07D211/22 ,  C07D211/26 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D417/10

摘要： Compounds of formula (I) and pharmaceutically-acceptable derivatives thereof, are matrix metalloprotease inhibitors, useful in treatment of conditions mediated by matrix metalloproteases, such as chronic dermal ulcers.

摘要翻译： 式（I）化合物及其药学上可接受的衍生物是可用于治疗由基质金属蛋白酶介导的病症如慢性皮肤溃疡的基质金属蛋白酶抑制剂。

公开(公告)号：US06936619B2

公开(公告)日：2005-08-30

申请号：US10387106

申请日：2003-03-12

申请人： Julian Blagg ,  Michael Jonathan Fray ,  Mark Llewellyn Lewis ,  John Paul Mathias ,  Mark Henryk Stefaniak ,  Alan Stobie

发明人： Julian Blagg ,  Michael Jonathan Fray ,  Mark Llewellyn Lewis ,  John Paul Mathias ,  Mark Henryk Stefaniak ,  Alan Stobie

IPC分类号： C07D239/95 ,  A61K31/517 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/5386 ,  A61P3/06 ,  A61P9/06 ,  A61P9/10 ,  A61P9/12 ,  A61P13/08 ,  A61P15/00 ,  A61P15/08 ,  A61P15/10 ,  A61P27/06 ,  A61P43/00 ,  C07D401/04 ,  C07D401/14 ,  C07D471/04 ,  C07D487/04 ,  C07D519/00

CPC分类号： C07D401/04 ,  C07D471/04 ,  C07D487/04

摘要： Compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, wherein R1 represents C1-4 alkyl; R2 represents halo, C1-4 alkyl, C3-6 cycloalkyl, C3-6 cycloalkyloxy, —SO2(C1-4 alkyl), optionally substituted C1-4 alkyloxy, Het or —OHet; R3 represents a bicyclic group of the formula  wherein X and Y are selected from C and N, provided that at least one is C; Ring A together with X and Y represents a 5- or 6-membered aromatic ring containing 0, 1, 2 or 3 nitrogen atoms in the ring; n is), 1 or 2 L represents a direct link, C1-4 alkylene or C1-4 alkoxyalkylene; R4 represents H, —NR5R6, C3-6 cycloalkyl, —OR7, Het1 or Het4; R5 and R6 are independently selected from H, C3-6 cycloalkyl, C3-6 cycloalkyl-C1-4 alkylene, —SO2(C1-4 alkyl) and optionally substituted C1-4 alkyl R7 is selected from H, C1-4 alkyl, C1-4 alkoxyalkyl, C3-6cycloalkyl, Het2 and C1-4alkyl-Het3; R8 is H or C1-4 alkyl; Het, Het1, Het2 and Het3 independently represent an optionally substituted 4 to 7 membered saturated heterocyclic group which may be mono- or bi-cyclic and which contains one or more heteroatoms selected from N, O or S; Het4 represents an optionally substituted 5 or 6 membered unsaturated heterocyclic group containing one or more heteroatoms selected from N, O or S; R9 is H or C1-4 alkyl; R10 and R11 are independently selected from H and C1-4 alkyl; are useful in the treatment of hypertension, myocardial infarction, male erectile dysfunction (MED), hyperlipidaemia, cardiac arrhythmia, glaucoma and benign prostatic hyperplasia (BPH). They also find utility in the treatment of female sexual arousal dysfunction (FSAD).

公开(公告)号：US06914160B1

公开(公告)日：2005-07-05

申请号：US10632438

申请日：2003-07-31

申请人： Duncan Robert Armour ,  Andrew Simon Bell ,  Paul John Edwards ,  David Ellis ,  David Hepworth ,  Mark Llewellyn Lewis ,  Christopher Ronald Smith

发明人： Duncan Robert Armour ,  Andrew Simon Bell ,  Paul John Edwards ,  David Ellis ,  David Hepworth ,  Mark Llewellyn Lewis ,  Christopher Ronald Smith

IPC分类号： A61K31/16 ,  A61P15/04 ,  A61P15/10 ,  C07C233/65 ,  C07C237/22 ,  C07C255/57 ,  C07D213/81 ,  C07D213/82 ,  C07D319/18 ,  C07D401/12 ,  C07D405/12 ,  C07D521/00

CPC分类号： C07C237/22 ,  C07C255/57 ,  C07D213/81 ,  C07D213/82 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D319/18 ,  C07D401/12 ,  C07D405/12

摘要： This invention relates to compounds of formula (I)

摘要翻译： 本发明涉及式（I）化合物，