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1.SYNTHESIS AND CRYSTALLINE FORMS OF CB-1 ANTAGONIST/INVERSE AGONIST 审中-公开
标题翻译: CB-1 ANTAGONIST / INVERSE AGONIST的合成和结晶形式公开(公告)号:US20100292282A1
公开(公告)日:2010-11-18
申请号:US12681797
申请日:2008-10-20
申请人: Kevin R. Campos , Cheng-Yi Chen , Jennifer R. Foley , Michael Hillier , Wendy S. Jen , Amude M. Kassim , Artis Klapars , Andrey V. Peresypkin , Thorsten Rosner , Cecile G. Savarin , Matthew Tudge , Narayan Variankaval , Vicky Vydra , Dalian Zhao
发明人: Kevin R. Campos , Cheng-Yi Chen , Jennifer R. Foley , Michael Hillier , Wendy S. Jen , Amude M. Kassim , Artis Klapars , Andrey V. Peresypkin , Thorsten Rosner , Cecile G. Savarin , Matthew Tudge , Narayan Variankaval , Vicky Vydra , Dalian Zhao
IPC分类号: A61K31/4245 , C07D413/10 , C07D271/113 , C07C255/53 , A61P3/04 , A61P3/10 , A61P25/28
CPC分类号: C07D271/113 , C07C255/53 , C07D413/10
摘要: The present invention relates to a process for producing crystalline 3-[(1S)-1-(1-{(S)-(4-chlorophenyl)[3-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)phenyl]methyl}azetidin-3-yl)-2-fluoro-2-methyl-propyl]-5-fluorobenzonitrile, and novel salts, solvates, hydrates and polymorphs thereof.
摘要翻译: 本发明涉及3 - [(1S)-1-(1 - {(S) - (4-氯苯基)[3-(5-氧代-4,5-二氢-1,3, 4-二唑-2-基)苯基]甲基}氮杂环丁烷-3-基)-2-氟-2-甲基 - 丙基] -5-氟苄腈及其新的盐,溶剂合物,水合物和多晶型物。