公开(公告)号：US06461808B1

公开(公告)日：2002-10-08

申请号：US09880746

申请日：2001-06-12

申请人： Kevin S. Bodner ,  Andrew P. Sandham

发明人： Kevin S. Bodner ,  Andrew P. Sandham

IPC分类号： C12Q100

CPC分类号： G01N22/00 ,  G01N33/54373 ,  Y10T436/11 ,  Y10T436/119163

摘要： A pipette-loaded bioassay includes a measurement probe and a pipette tip. The measurement probe includes a probe head configured to launch an incident test signal and a connecting end configured to receive the incident test signal from a signal source. The pipette tip includes a sample interrogation region which is electromagnetically coupled to the probe head, the sample interrogation region configured to retain a plug of sample solution and constructed from a material which is substantially transparent to the incident test signal. The incident test signal electromagnetically couples through the sample interrogation region and to the molecular or cellular events occurring within the sample solution. The interaction of the incident test signal with the molecular or cellular events produces a modulated test signal which can be recovered and used to identify the molecular or cellular events occurring in a subsequently tested sample.

摘要翻译： 移液管装载的生物测定包括测量探针和移液管尖。 测量探头包括被配置为发射入射测试信号的探头和被配置为从信号源接收入射测试信号的连接端。 移液管尖端包括电磁耦合到探针头的样品询问区域，样品询问区域被配置为保持样品溶液塞并由对入射的测试信号基本透明的材料构成。 事件测试信号通过样品询问区域电磁耦合到样品溶液中发生的分子或细胞事件。 事件测试信号与分子或细胞事件的相互作用产生调制的测试信号，其可以被回收并用于鉴定随后测试的样品中发生的分子或细胞事件。