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公开(公告)号：US09976941B2
公开(公告)日：2018-05-22
申请号：US15256159
申请日：2016-09-02
申请人： Lee H. Angros
发明人： Lee H. Angros
CPC分类号： G01N1/30 , B01L9/52 , G01N1/312 , G01N1/44 , G01N33/52 , G01N33/521 , G01N33/53 , G01N33/5306 , G01N35/00029 , G01N35/00584 , G01N2035/00138 , G01N2035/00346 , Y10T436/11 , Y10T436/110833 , Y10T436/111666 , Y10T436/112499 , Y10T436/114165 , Y10T436/114998 , Y10T436/119163 , Y10T436/25 , Y10T436/2575
摘要： An automated in situ heat induced antigen recovery and staining method and apparatus for treating a plurality of microscope slides. The process of heat induced antigen recovery and the process of staining the biological specimen on the microscope slide are conducted in the same apparatus, wherein the microscope slides do not need to be physically removed from one apparatus to another. The reaction conditions for treating a slide can preferably be controlled independently, including the individualized application of reagents to each slide and the individualized treatment of each slide.
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2.发明申请公开(公告)号：US20170370928A1
公开(公告)日：2017-12-28
申请号：US15681647
申请日：2017-08-21
发明人： Ronald Norman Diamond , Steven Michael Gann , Eric Darnell Hall , Tae Ho Hwang , John Lewis Morton , Anatoly Moskalev , Bruce Alan Sargeant , Dennis Edwin Rieger , Marinela Gombosev , Mark David Van Cleve
IPC分类号： G01N33/564 , G01N21/64 , G01N21/76 , G01N33/53 , G01N33/569 , G01N33/58 , G01N33/68 , G01N35/10 , G01N35/00 , G01N33/543 , G01N35/04
CPC分类号： G01N21/645 , G01N21/6428 , G01N21/76 , G01N33/5306 , G01N33/54326 , G01N33/5434 , G01N33/54393 , G01N33/564 , G01N33/569 , G01N33/5695 , G01N33/56983 , G01N33/582 , G01N33/6854 , G01N33/6893 , G01N35/0098 , G01N35/1011 , G01N2021/6484 , G01N2035/0453 , G01N2035/1062 , G01N2201/062 , G01N2201/08 , G01N2333/4703 , G01N2333/62 , G01N2333/78 , G01N2800/24 , Y10T436/119163
摘要： Apparatuses and methods of optically analyzing fluid within a pipette are described herein. In an embodiment, an optical reader subassembly includes a pipette configured to aspirate and hold a fluid sample within its tip, a housing configured to receive at least the tip of the pipette through a reentrant seal so that the tip of the pipette is located in a light tight manner within an internal area, a light source positioned to be in proximity to the tip of the pipette when the tip of the pipette is received by the housing, the light source configured to project light through the tip of the pipette and onto the fluid sample held within the tip, and an optical sensor configured to take a reading of the fluid sample held within the tip of the pipette without any of the fluid sample being injected from the pipette.
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公开(公告)号：US09664675B2
公开(公告)日：2017-05-30
申请号：US14960593
申请日：2015-12-07
CPC分类号： G01N33/5302 , G01N35/0098 , G01N35/1083 , G01N35/1095 , Y10T436/115831 , Y10T436/119163
摘要： Stepped portions of a flow channel are reduced by completely fixing the channel that extends to the measuring unit, and reducing connections in the channel, thereby to suppress a disturbance in the flow of the liquid suctioned into the measuring unit. A means is provided so that the reaction solution and reagent suctioned will move towards the channel through which the liquids are suctioned.
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公开(公告)号：US20160370390A1
公开(公告)日：2016-12-22
申请号：US15256159
申请日：2016-09-02
申请人： Lee H. Angros
发明人： Lee H. Angros
CPC分类号： G01N1/30 , B01L9/52 , G01N1/312 , G01N1/44 , G01N33/52 , G01N33/521 , G01N33/53 , G01N33/5306 , G01N35/00029 , G01N35/00584 , G01N2035/00138 , G01N2035/00346 , Y10T436/11 , Y10T436/110833 , Y10T436/111666 , Y10T436/112499 , Y10T436/114165 , Y10T436/114998 , Y10T436/119163 , Y10T436/25 , Y10T436/2575
摘要： An automated in situ heat induced antigen recovery and staining method and apparatus for treating a plurality of microscope slides. The process of heat induced antigen recovery and the process of staining the biological specimen on the microscope slide are conducted in the same apparatus, wherein the microscope slides do not need to be physically removed from one apparatus to another. The reaction conditions for treating a slide can preferably be controlled independently, including the individualized application of reagents to each slide and the individualized treatment of each slide.
摘要翻译： 一种用于处理多个显微镜载片的自动原位热诱导抗原恢复和染色方法和装置。 在相同的装置中进行热诱导的抗原恢复过程和在显微镜载玻片上染色生物样品的过程，其中显微镜幻灯片不需要从一个装置物理移除到另一个装置。 用于处理载玻片的反应条件可以独立地进行控制，包括将试剂单独施加到每个载玻片上，以及每个载玻片的个体化处理。
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公开(公告)号：US09176033B2
公开(公告)日：2015-11-03
申请号：US14072481
申请日：2013-11-05
申请人： Lee H. Angros
发明人： Lee H. Angros
CPC分类号： G01N1/30 , B01L9/52 , G01N1/312 , G01N1/44 , G01N33/52 , G01N33/521 , G01N33/53 , G01N33/5306 , G01N35/00029 , G01N35/00584 , G01N2035/00138 , G01N2035/00346 , Y10T436/11 , Y10T436/110833 , Y10T436/111666 , Y10T436/112499 , Y10T436/114165 , Y10T436/114998 , Y10T436/119163 , Y10T436/25 , Y10T436/2575
摘要： An automated in situ heat induced antigen recovery and staining method and apparatus for treating a plurality of microscope slides. The process of heat induced antigen recovery and the process of staining the biological sample on the microscope slide are conducted in the same apparatus, wherein the microscope slides do not need to be physically removed from one apparatus to another. The reaction conditions for treating a slide can preferably be controlled independently, including the individualized application of reagents to each slide and the individualized treatment of each slide.
摘要翻译： 一种用于处理多个显微镜载片的自动原位热诱导抗原恢复和染色方法和装置。 在相同的装置中进行热诱导的抗原恢复过程和在显微镜载玻片上染色生物样品的过程，其中显微镜幻灯片不需要从一个装置物理移除到另一个装置。 用于处理载玻片的反应条件可以独立地进行控制，包括将试剂单独施加到每个载玻片上，以及每个载玻片的个体化处理。
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6.发明申请公开(公告)号：US20150308944A1
公开(公告)日：2015-10-29
申请号：US14794394
申请日：2015-07-08
申请人： TECAN TRADING AG
CPC分类号： G01N21/59 , B01L3/021 , B01L3/0241 , G01N21/01 , G01N21/17 , G01N21/33 , G01N21/64 , G01N21/645 , G01N21/6486 , G01N35/1009 , G01N2021/0162 , G01N2021/0314 , G01N2021/035 , G01N2021/8564 , G01N2035/1046 , G01N2035/1062 , G01N2201/0612 , G01N2201/062 , G01N2201/08 , Y10T436/11 , Y10T436/119163 , Y10T436/143333 , Y10T436/2575
摘要： Optical measuring apparatus configured for analysis of samples contained in liquid drops provided by a liquid handling system that comprises at least one liquid handling tip. The apparatus comprises a light source for irradiating the drop; a detector for measuring sample light; an optics system with first optical elements for transmitting irradiation light, and a processor for accepting and processing measurement signals. The drop is suspended at the liquid handling orifice of the tip in a position where the drop is penetrated by a first optical axis defined by the light source and the first optical elements. The drop is physically touched only by the tip and the liquid sample inside the tip. A robot arm to which the tip is attached is configured as a mechanism for adapting the position of the liquid drop with respect to at least one optical element of the optics system.
摘要翻译： 光学测量装置，其被配置用于分析由液体处理系统提供的液滴中包含的样品，所述液体处理系统包括至少一个液体处理尖端。 该装置包括用于照射该液滴的光源; 用于测量样品光的检测器; 具有用于发射照射光的第一光学元件的光学系统和用于接收和处理测量信号的处理器。 液滴悬挂在尖端的液体处理孔处，其中液滴被由光源和第一光学元件限定的第一光轴穿透。 滴液仅由尖端和尖端内的液体样品物理接触。 配置有尖端的机器人臂被配置为用于相对于光学系统的至少一个光学元件适配液滴的位置的机构。
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公开(公告)号：US09157922B2
公开(公告)日：2015-10-13
申请号：US14330548
申请日：2014-07-14
发明人： Yuji Saito , Fumio Takagi
CPC分类号： G01N35/1002 , B01L3/0241 , B01L7/52 , B01L2300/0838 , B01L2400/0457 , B01L2400/049 , G01N1/10 , G01N1/14 , G01N1/38 , G01N35/1016 , Y10T436/118339 , Y10T436/119163 , Y10T436/25 , Y10T436/2575
摘要： A dispensing method which dispenses a first liquid contained in a first vessel which stores the first liquid and a second liquid to introduce the first liquid into a second vessel by using a tube.
摘要翻译： 一种分配方法，其分配容纳在存储第一液体的第一容器中的第一液体和第二液体，以通过使用管将第一液体引入第二容器。
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公开(公告)号：US20150037896A1
公开(公告)日：2015-02-05
申请号：US14285907
申请日：2014-05-23
申请人： Paul Frank , Andreas Gisler , Robert Huesler , Rolf Knobel , Siegfried Mueller , Urs Schnieper , Heinz Trueeb
发明人： Paul Frank , Andreas Gisler , Robert Huesler , Rolf Knobel , Siegfried Mueller , Urs Schnieper , Heinz Trueeb
CPC分类号： G01N35/1095 , B01L3/0275 , G01N35/0098 , G01N35/028 , G01N35/1067 , G01N35/1074 , G01N2035/00326 , G01N2035/103 , G01N2035/1069 , Y10T436/11 , Y10T436/114998 , Y10T436/119163 , Y10T436/2575
摘要： A method is described for distributing samples within an automated analyzer from a linear arrangement of sample vessels to a processing plate in a two-dimensional n×m arrangement wherein samples are sorted, followed by transfer with a pipetting device with a linear arrangement to a processing vessel in a two-dimensional n×m arrangement and subsequent processing of samples using a second pipetting device which has a two-dimensional n×m arrangement.
摘要翻译： 描述了一种用于将自动分析仪中的样品从样品容器的线性排列分布到二维n×m布置的处理板的方法，其中样品被分类，然后用具有线性排列的移液装置转移到处理 容器以二维n×m布置，并且使用具有二维n×m布置的第二移液装置对样品进行后续处理。
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9.发明申请DEVICE AND ASSOCIATED METHODS FOR PERFORMING LUMINESCENCE AND FLUORESCENCE MEASUREMENTS OF A SAMPLE 有权用于实施样品的发光和荧光测量的装置和相关方法公开(公告)号：US20140273277A1
公开(公告)日：2014-09-18
申请号：US14215861
申请日：2014-03-17
发明人： Ronald Norman Diamond , Steve Michael Gann , Eric Darnell Hall , Tae Ho Hwang , John Lewis Morton , Anatoly Moskalev , Bruce Alan Sargeant , Dennis Edwin Rieger , Marinela Gombosev , Mark David Van Cleve
CPC分类号： G01N21/645 , G01N21/6428 , G01N21/76 , G01N33/5306 , G01N33/54326 , G01N33/5434 , G01N33/54393 , G01N33/564 , G01N33/569 , G01N33/5695 , G01N33/56983 , G01N33/582 , G01N33/6854 , G01N33/6893 , G01N35/0098 , G01N35/1011 , G01N2021/6484 , G01N2035/0453 , G01N2035/1062 , G01N2201/062 , G01N2201/08 , G01N2333/4703 , G01N2333/62 , G01N2333/78 , G01N2800/24 , Y10T436/119163
摘要： An apparatus for measuring the luminescence and the fluorescence of a sample, comprising: a light tight optics box capable of receiving a pipette tip containing a sample; an optical sensor located within the optics box and capable of being disposed in both a luminescence reading position and a fluorescence reading position; an excitation light fiber optic bundle and a sample transmission fiber optic bundle; an excitation light assembly that projects excitation light onto a first terminus end of the excitation light fiber optic bundle; and an in-line filter located along the sample transmission fiber optic bundle.
摘要翻译： 一种用于测量样品的发光和荧光的装置，包括：能够接收含有样品的移液管尖端的不透光光学盒; 光学传感器位于光学盒内并且能够被布置在发光读取位置和荧光读取位置; 激发光纤光束和样品传输光纤束; 激发光组件，其将激发光投射到激发光纤光束的第一末端; 以及沿着样品传输光纤束定位的串联滤波器。
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10.发明申请公开(公告)号：US20140206093A1
公开(公告)日：2014-07-24
申请号：US13746722
申请日：2013-01-22
申请人： TECAN TRADING AG
IPC分类号： G01N21/17
CPC分类号： G01N21/17 , B01L3/021 , B01L3/0241 , G01N15/0227 , G01N21/01 , G01N21/03 , G01N21/33 , G01N21/49 , G01N21/645 , G01N2015/0038 , G01N2015/0693 , G01N2021/0314 , G01N2021/035 , G01N2021/8564 , G01N2035/1046 , Y10T436/11 , Y10T436/119163 , Y10T436/143333 , Y10T436/2575
摘要： An optical measuring apparatus and method for analysis of samples contained in liquid drops provided by a liquid handling system has a liquid handling tip. A light source irradiates the liquid drop; a detector measures sample light; and an optics system with first optical elements transmits irradiation light, and a processor processes the measurement signals. The liquid drop is suspended at the liquid handling orifice of the liquid handling tip in a position where the liquid drop is penetrated by a first optical axis defined by the light source and the first optical elements. The liquid drop is physically touched only by the liquid handling tip and the liquid sample inside the liquid handling tip. A mutual adaption of the size and position of the liquid drop with respect to the first optical elements is achieved.
摘要翻译： 用于分析由液体处理系统提供的液滴中包含的样品的光学测量装置和方法具有液体处理尖端。 光源照射液滴; 检测器测量样品光; 并且具有第一光学元件的光学系统透射照射光，并且处理器处理测量信号。 液滴在液体处理尖端的液体处理孔处悬挂在液滴被由光源和第一光学元件限定的第一光轴穿透的位置处。 只有液体处理尖端和液体处理尖端内的液体样品物理地接触液滴。 实现液滴相对于第一光学元件的尺寸和位置的相互适应。
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