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    Bradykinin-antagonists for the treatment of acute pancreatitis
    2.
    发明授权
    Bradykinin-antagonists for the treatment of acute pancreatitis 失效
    缓激肽拮抗剂治疗急性胰腺炎

    公开(公告)号：US5670619A

    公开(公告)日：1997-09-23

    申请号：US232338

    申请日：1994-04-22

    申请人： Thomas Griesbacher ,  Fred Lembeck

    发明人： Thomas Griesbacher ,  Fred Lembeck

    IPC分类号： A61K38/00 ,  A61K20060101 ,  A61K38/04 ,  A61K38/08 ,  A61P1/00 ,  A61P1/18 ,  A61P7/00 ,  A61P43/00 ,  C07K20060101 ,  C07K7/06 ,  C07K7/18

    CPC分类号： A61K38/043 ,  A61K38/08

    摘要： The invention relates to the use of bradykinin-antagonists of the formula R.sup.1 -A-B-C-E-F-G-J-K-R.sup.2 wherein R.sup.1 represents hydrogen, C.sub.1 -C.sub.4 -alkanoyl which can be substituted by mercapto, hydroxyphenyl, (4-benzoyl)phenoxy or represents (4-benzoyl)benzoyl-Lys; A represents D-Arg or D-Lys or stands for a direct bond; B represents Arg which can be substituted by NO.sub.2 or toluol-4-sulfonyl or represents Lys which can be substituted by toluol-4-sulfonyl or CO--NH--C.sub.6 H.sub.5, or stands for a direct bond; C represents Hyp-Pro-Gly, Pro-Hyp-Gly, Pro-Pro-Gly or dehydroPro-Hyp-Gly; E represents Thi, Phe, Leu or Cha; F represents Ser or Cys; G represents D-Tic, D-Phe or D-Hyp substituted by C.sub.1 -C.sub.4 -alkoxy; J represents Tic, Aoc or Oic; K represents Arg or Ahx or stands for a direct bond; R.sup.2 is hydroxy or amino; and the physiologically tolerable salts thereof for the treatments of acute pancreatitis, to pharmaceutical agents containing them and to the use thereof for the preparation of appropriate pharmaceutical compositions.

    摘要翻译： 本发明涉及式R1-ABCEFGJK-R2的缓激肽拮抗剂的用途，其中R1表示氢，可被巯基，羟基苯基，（4-苯甲酰基）苯氧基取代的C 1 -C 4 - 烷酰基或代表（4-苯甲酰基）苯甲酰基 - 赖氨酸 A代表D-Arg或D-Lys或代表直接键; B表示可被NO 2或甲苯-4-磺酰基取代的Arg，或表示可被甲苯-4-磺酰基或CO-NH-C6H5取代的Lys，或代表直接键; C代表Hyp-Pro-Gly，Pro-Hyp-Gly，Pro-Pro-Gly或脱氢Pro-Hyp-Gly; E代表Thi，Phe，Leu或Cha; F代表Ser或Cys; G表示被C 1 -C 4 - 烷氧基取代的D-Tic，D-Phe或D-Hyp; J代表Tic，Aoc或Oic; K代表Arg或Ahx或代表直接键; R2是羟基或氨基; 及其用于治疗急性胰腺炎的生理上可耐受的盐，以及含有它们的药物及其用于制备合适的药物组合物的用途。