公开(公告)号：US20230046756A1

公开(公告)日：2023-02-16

申请号：US17765972

申请日：2020-09-29

申请人： KoBioLabs, Inc.

发明人： Tae Wook Nam ,  Kiuk Lee ,  Seok Cheon Song ,  Seung Hyeok Han ,  Bo Young Nam ,  Ji Min Park

IPC分类号： C12N1/20 ,  A23L33/135 ,  A23K10/16 ,  A61K35/747 ,  A61P13/12

摘要： The present invention relates to a Lactobacillus acidophilus KBL409 strain and uses thereof, wherein the Lactobacillus acidophilus KBL409 (deposit number KCTC 13518BP) strain according to the present invention reduces inflammation of the kidney, reduce the concentration of uremic toxins such as blood urea nitrogen, creatinine and p-cresol to protect the kidney, and thus may be usefully utilized for prophylactic and therapeutic applications of renal diseases including improving renal function and chronic renal failure.

公开(公告)号：US11633439B2

公开(公告)日：2023-04-25

申请号：US17448620

申请日：2021-09-23

申请人： KoBioLabs, Inc.

发明人： Woo Ri Ko ,  June Chul Lee ,  Tae-Wook Nam ,  Gwang Pyo Ko ,  Hyun Ju You ,  So Yon Yoon ,  Seok Cheon Song

IPC分类号： A61K35/747 ,  A23L33/135 ,  A61P11/06 ,  A61P37/08 ,  A61P31/10 ,  A61K8/99

摘要： A strain of Lactobacillus crispatus KBL693 and the use thereof are disclosed. The strain of Lactobacillus crispatus KBL693 (Accession No. KCTC 13519BP) attenuates allergic reactions of cells, significantly improves symptoms of atopic dermatitis, and exhibits anti-inflammatory and anti-fungal effects. Thus, the single strain alone can achieve all the purposes of alleviating atopic dermatitis and other allergic diseases and improving inflammatory diseases and autoimmune diseases, thereby finding advantageous applications as a probiotic substance. In addition, the strain, based on the anti-fungal activity thereof, can be advantageously utilized in a skin external preparation against various skin diseases caused by fungi, and in a cosmetic composition and a functional patch for alleviating sensitive skin.