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18 条记录 (耗时 0.024 秒)

    Injection syringe including device for preparation of injection
    1.
    发明授权
    Injection syringe including device for preparation of injection 有权
    注射器包括注射装置

    公开(公告)号：US06319225B1

    公开(公告)日：2001-11-20

    申请号：US09266916

    申请日：1999-03-12

    申请人： Koichi Sugita ,  Sei Kirihara ,  Hiromichi Ishikawa ,  Yutaka Igarashi

    发明人： Koichi Sugita ,  Sei Kirihara ,  Hiromichi Ishikawa ,  Yutaka Igarashi

    IPC分类号： A61M3700

    CPC分类号： A61M5/2448 ,  A61M5/31553 ,  A61M5/31591

    摘要： An injection syringe including a device for preparation of an injection in situ, useful to the injection which is liable to suffer chemical changes if left for a long time in the state of solution or dispersion ready to inject. The injection syringe is portable by a patient who may prepare a necessary injection in situ with the use of a device included in the syringe which will automatically perform an injection with a prescribed dosage. The injection syringe includes a device for preparation of an injection, whereby mechanical impacts affecting the medicine and consequently, chemical changes with a medicine would be minimized during the step of dissolving the medicine. The syringe as noted is especially useful for preparation of injection and injection of human growth hormones, interferon and various polypeptides which are of an environmentally sensitive nature and liable to suffer chemical changes if left for a long time in the state of solution or dispersion.

    摘要翻译： 一种注射器，其包括用于制备原位注射的装置，其用于注射，如果在准备注射的溶液或分散体的状态下长时间存在易于发生化学变化。 注射器可以由患者便携，该患者可以使用包括在注射器中的装置在现场准备必要的注射器，其将以规定剂量自动进行注射。 注射器包括用于制备注射器的装置，由此在溶解药物的步骤期间，影响药物的机械冲击以及因此的药物的化学变化将被最小化。 如上所述，注射器特别适用于制备注射和注射人生长激素，干扰素和各种具有环境敏感性质的多肽，并且如果在溶液或分散状态下长时间使用，则易于遭受化学变化。

    Injection syringe
    3.
    发明授权
    Injection syringe 失效
    注射器

    公开(公告)号：US06645179B1

    公开(公告)日：2003-11-11

    申请号：US09611660

    申请日：2000-07-06

    申请人： Hiromichi Ishikawa ,  Shinichi Koni

    发明人： Hiromichi Ishikawa ,  Shinichi Koni

    IPC分类号： A61M500

    CPC分类号： A61M5/2448 ,  A61M5/3129 ,  A61M5/315 ,  A61M5/31505 ,  A61M5/31551 ,  A61M5/3158 ,  A61M5/31591 ,  A61M5/502

    摘要： An injection syringe generally comprised of a multichambered cylindrical ampule, a tripartite case of a front case; a middle case; a rear case, and a needle-holder, and a plunger: the multichambered cylindrical ampule including two chambers of a front space and a rear space, the front space being sealed forwardly with a packing penetrable by a needle and sealed rearwardly with a movable front gasket, and the rear space being sealed forwardly with the front gasket and sealed rearwardly with a movable rear gasket, and the ampule also including a bypass route longitudinally arranged on inner surface of the ampule such that the front gasket is located to take a position rearwardly apart from the bypass route before dissolution of a solid medicine, wherein the front space for admission of the solid medicine is separated from the rear space for admission of a medicinal solvent or dispersing agent; the middle case also including a short thread or fixer means provided externally at midportion thereof, and the rear case including another short thread or fixer means provided internally at the front end thereof. The present invention brings out the merits of facilitating injections in the use of unstable chemicals, and avoiding possible inclusion of foreign matters or microorganisms, and overcoming misoperations possible during complex preparation procedure, inability to comply with an urgent case, such are attendant defects with traditional injection syringes.

    摘要翻译： 通常由多功能圆柱形安瓿组成的注射式注射器，前壳体的三部分壳体; 中间案件 一个后壳和一个针架，以及一个柱塞：多个圆柱形的安瓿，包括前空间和后空间的两个腔室，前空间被一个可以被针刺的填料向前密封， 垫圈，并且后部空间与前垫圈向前密封并且用可移动的后垫圈向后密封，并且安瓿还包括纵向布置在安瓿的内表面上的旁路路径，使得前垫圈定位成向后 除了固体药物溶出前的旁通路径之外，其中用于进入固体药物的前部空间与后部空间分离以进入药物溶剂或分散剂; 中间壳体还包括在其中部设置在外部的短螺纹或定位装置，并且后壳体包括设置在其前端内部的另一短螺纹或定位装置。 本发明提出了促进注射使用不稳定化学品的优点，并避免可能引入异物或微生物，克服复杂制备过程中可能的误操作，不能遵守紧急情况，如传统的伴随缺陷 注射器

    Quinoline-3-acetic acid derivative, process for production thereof and use thereof
    4.
    发明授权
    Quinoline-3-acetic acid derivative, process for production thereof and use thereof 失效
    喹啉-3-乙酸衍生物，其制备方法及其用途

    公开(公告)号：US5543420A

    公开(公告)日：1996-08-06

    申请号：US295876

    申请日：1994-11-01

    申请人： Tomoji Aotsuka ,  Toshiyuki Nishio ,  Hiroshi Hosono ,  Yoshiyuki Nakamura ,  Tetsuo Matsui ,  Hiromichi Ishikawa

    发明人： Tomoji Aotsuka ,  Toshiyuki Nishio ,  Hiroshi Hosono ,  Yoshiyuki Nakamura ,  Tetsuo Matsui ,  Hiromichi Ishikawa

    IPC分类号： A61K31/47 ,  A61K31/4709 ,  A61P3/08 ,  A61P3/10 ,  A61P13/02 ,  A61P13/12 ,  A61P15/00 ,  A61P25/00 ,  A61P25/02 ,  A61P27/02 ,  A61P27/12 ,  A61P43/00 ,  C07D417/06 ,  A61K31/425 ,  C07D215/227

    CPC分类号： C07D417/06

    摘要： A quinoline-3-acetic acid derivative of the formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are the same or different and each is a hydrogen atom or a halogen atom, R.sup.4 is a hydrogen atom, a halogen atom or a substituted or unsubstituted lower alkyl, R.sup.5 is an optionally esterified carboxyl and the broken line means an optional presence of a double bond, and a pharmaceutically acceptable salt thereof. The novel compound of the formula (I) and a pharmaceutically acceptable salt thereof of the present invention have an aldose reductase inhibitory activity in mammals inclusive of human and are highly safe. Accordingly, they are useful as pharmaceutical compositions for the treatment of the complications of diabetes, such as faulty union of corneal injury, cataract, neurosis, retinopathy and nephropathy, particularly cataract and neurosis.

    摘要翻译： PCT No.PCT / JP94 / 00007 Sec。 371日期：1994年11月10日 102（e）1994年11月10日日期PCT 1994年1月6日PCT PCT。 第WO94 / 15934号公报 日期：1994年7月21日分子式为其中R 1，R 2和R 3相同或不同并且各自为氢原子或卤素原子的式（I）的喹啉-3-乙酸衍生物，R4为氢原子， 卤素原子或取代或未取代的低级烷基，R 5为任意酯化的羧基，虚线表示任选存在双键，以及其药学上可接受的盐。 本发明式（I）的新化合物及其药学上可接受的盐在包括人的哺乳动物中具有醛糖还原酶的抑制活性，并且是高度安全的。 因此，它们可用作治疗糖尿病并发症的药物组合物，例如角膜损伤，白内障，神经症，视网膜病变和肾病，尤其是白内障和神经症的错综联合。

    1,4-benzoxazine-2-acetic acid compound, method for production thereof and use thereof
    8.
    发明授权
    1,4-benzoxazine-2-acetic acid compound, method for production thereof and use thereof 失效
    1,4-苯并恶嗪-2-乙酸化合物，其制备方法和用途

    公开(公告)号：US5635505A

    公开(公告)日：1997-06-03

    申请号：US666326

    申请日：1996-07-03

    申请人： Takahiro Kumonaka ,  Takema Hase ,  Tomoji Aotsuka ,  Toshio Kurihara ,  Yoshiyuki Nakamura ,  Tetsuo Matsui ,  Hiromichi Ishikawa ,  Fujio Kobayashi

    发明人： Takahiro Kumonaka ,  Takema Hase ,  Tomoji Aotsuka ,  Toshio Kurihara ,  Yoshiyuki Nakamura ,  Tetsuo Matsui ,  Hiromichi Ishikawa ,  Fujio Kobayashi

    IPC分类号： C07D417/06 ,  A61K31/535

    CPC分类号： C07D417/06

    摘要： A 1,4-benzoxazine-2-acetic acid compound of the formula (I) ##STR1## wherein each symbol is as defined in the specification, a pharmaceutically acceptable salt thereof, a method for production thereof, and a pharmaceutical composition, an aldose reductase inhibitor and an agent for the prevention and/or treatment of the complications of diabetes, which contain the same. The compound (I) of the present invention and pharmaceutically acceptable salts thereof have aldose reductase inhibitory action and are superior in safety. Accordingly, they are useful as an agent for the prevention and/or treatment of the complications of diabetes such as faulty union of corneal injury, cataract, neurosis, retinopathy and nephropathy, in particular, cataract and neurosis.

    摘要翻译： PCT No.PCT / JP94 / 00005 Sec。 371日期：1996年7月3日 102（e）日期1996年7月3日PCT 1994年1月6日PCT PCT。 出版物WO95 / 18805 日期1995年7月13日具有式（I）的1,4-苯并恶嗪-2-乙酸化合物其中各符号如说明书中所定义，其药学上可接受的盐，其制备方法 ，以及药物组合物，醛糖还原酶抑制剂和用于预防和/或治疗糖尿病并发症的药剂，其含有该组合物。 本发明的化合物（I）及其药学上可接受的盐具有醛糖还原酶抑制作用，安全性优异。 因此，它们可用作预防和/或治疗糖尿病并发症的药剂，例如角膜损伤，白内障，神经症，视网膜病变和肾病，尤其是白内障和神经症。

    Ink ribbon cassette
    9.
    发明授权
    Ink ribbon cassette 失效
    墨带盒

    公开(公告)号：US4838715A

    公开(公告)日：1989-06-13

    申请号：US160043

    申请日：1988-02-24

    申请人： Hiromichi Ishikawa

    发明人： Hiromichi Ishikawa

    IPC分类号： B41J31/16

    CPC分类号： B41J31/16

    摘要： An ink ribbon cassette for supplying ink from an ink-impregnated material to an ink ribbon in which the ink-impregnated material is loaded directly in the cassette body without an ink tank, and in which leakage of ink caused, for instance, by vibration or sudden temperature change, is positively prevented. The ribbon cassette includes a cassette body having a container formed as an integral part thereof and a cover fixedly secured to the cassette body. The container accommodating the ink-impregnated material is formed in such a manner that a space is formed between the ink-impregnated material and the cover, and an ink pool having a capillary action is formed on the inner surface of an outer peripheral wall defining the container.

    摘要翻译： 一种用于将油墨从浸渍墨水供应到墨带的墨带盒，其中墨水浸渍材料直接装载在盒体中而没有墨水罐，并且其中例如通过振动或 突然的温度变化，是积极的。 色带盒包括具有形成为其整体部分的容器和固定地固定到盒体上的盖的盒体。 容纳浸渍油墨的容器的容器形成为在浸墨材料和盖子之间形成空间，并且在外周壁的内表面上形成具有毛细作用的墨池， 容器。