Substituted vinyl pyridine derivative and drugs containing the same
    7.
    发明授权
    Substituted vinyl pyridine derivative and drugs containing the same 失效
    取代的乙烯基吡啶衍生物和含有它的药物

    公开(公告)号:US5935977A

    公开(公告)日:1999-08-10

    申请号:US68986

    申请日:1998-05-26

    摘要: The present invention relates to a substituted vinylpyridine derivative represented by the following formula (1): ##STR1## (wherein R.sup.1 represents a hydrogen atom, an alkyl group, etc., R.sup.2 represents an alkyl group; one of R.sup.3 and R.sup.4, which are different from each other, represents a hydrogen atom and the other represents a nitrile group, R.sup.5 represents an aryl group or a heteroaryl group, X represents an oxygen atom, etc., and one of Q.sup.1, Q.sup.2, and Q.sup.3 represents a nitrogen atom and the other two represent CH); a salt of the derivative; and a drug containing the derivative or salt as the active ingredient. Due to strong PDE inhibitory action and TNF-.alpha. production inhibitory action, the derivative, salt, and drug are useful for the prevention and treatment of a wide variety of inflammatory diseases and autoimmune diseases.

    摘要翻译: PCT No.PCT / JP97 / 03354 Sec。 371日期:1998年5月26日 102(e)日期1998年5月26日PCT 1997年9月22日PCT公布。 公开号WO98 / 13348 日期:1998年4月2日本发明涉及由下式(1)表示的取代乙烯基吡啶衍生物:其中,R1表示氢原子,烷基等,R2表示烷基,R3和R4之一, 彼此不同,表示氢原子,另一个表示腈基,R 5表示芳基或杂芳基,X表示氧原子等,Q 1,Q 2和Q 3中的一个表示氮 原子,另外两个表示CH); 衍生物的盐; 和含有衍生物或盐的活性成分的药物。 由于强烈的PDE抑制作用和TNF-α产生抑制作用,衍生物,盐和药物可用于预防和治疗各种炎性疾病和自身免疫性疾病。