公开(公告)号：US20230029377A1

公开(公告)日：2023-01-26

申请号：US17842610

申请日：2022-06-16

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jin Woo Kim ,  Eun Jung Lee

IPC: C12N15/113 ,  A61P27/02 ,  C12N9/22 ,  C12N15/11

Abstract: The present invention relates to a technique capable of treating a retinal neurodegenerative disease through regeneration of a retinal nerve by targeting Prox1 in the mammalian retina using an inhibitor which inhibits Prox1 expression or migration. According to the present invention, inducing the regeneration of the damaged retina in mammals, and thus can be commonly applied to the treatment of various retinal neurodegenerative diseases causing vision loss, and furthermore, when combining with a selective retinal nerve differentiation method or the like, it is expected that the method can be used for the development of an innovative retinal regeneration method capable of selectively regenerating only specific degenerating retinal neurons.

公开(公告)号：US12091448B2

公开(公告)日：2024-09-17

申请号：US18089393

申请日：2022-12-27

Applicant: Korea Advanced Institute of Science and Technology

Inventor： Jin Woo Kim ,  Eun Jung Lee

IPC: C07K16/18 ,  C12N15/86

CPC classification number: C07K16/18 ,  C12N15/86 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/622 ,  C12N2750/14143

Abstract: The present disclosure relates to a PROX1 (Prospero homeobox protein 1) protein binding molecule. More specifically, the binding molecule of the present disclosure relates to a binding molecule having excellent binding ability to the PROX1 protein and having an excellent neutralizing effect on the PROX1 protein, and it is very useful for diagnosis, prevention or treatment of retinal neurodegenerative diseases.

公开(公告)号：US11851465B2

公开(公告)日：2023-12-26

申请号：US17110924

申请日：2020-12-03

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jin Woo Kim ,  Eun Jung Lee

IPC: C07K14/47

CPC classification number: C07K14/4702

Abstract: Disclosed is a method for regulating the extracellular secretion ability of a homeoprotein and a homeoprotein variant having regulated extracellular secretion ability using the same, and more particularly, a method for increasing or decreasing the extracellular secretion ability through the increase or decrease in hydrophobicity of an amino acid sequence among homeodomain external amino acid sequences, or a homeoprotein whose extracellular secretion ability is increased or decreased through the increase or decrease in hydrophobicity of the homeodomain external amino acid sequence.