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公开(公告)号：US09879232B2
公开(公告)日：2018-01-30
申请号：US14883757
申请日：2015-10-15
发明人： Sang Gu Yeo , Ho Sun Son , June Woo Lee , Seung Bin Cha , Sun Hwa Lee , Kwi Sung Park , Sang Won Lee
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5254 , C12N2710/24121 , C12N2710/24134 , C12N2710/24164
摘要： The attenuated vaccinia virus strain KVAC103 was obtained by subculturing a vaccinia virus strain 103 times in VERO cells. The attenuated vaccinia virus strain KVAC103 has significantly low toxicity, shows reduced skin lesions, and, at the same time, induces effectively immune responses to poxvirus. Thus, it can be used as a poxvirus vaccine while causing less side effects.
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公开(公告)号：US09879281B2
公开(公告)日：2018-01-30
申请号：US14883752
申请日：2015-10-15
发明人： Ho Sun Son , Sang Gu Yeo , Sang Won Lee
CPC分类号： C12N15/86 , A61K39/07 , C12N2710/24121 , C12N2710/24134 , C12N2710/24143
摘要： Disclosed herein is a novel recombinant virus vector derived from the attenuated vaccinia virus strain KVAC103. The recombinant virus vector is obtained by inserting an exogenous gene into the KVAC103 and may be used as a safe vaccine delivery vehicle in mammals. Particularly, recombinant viruses obtained by rescuing some of the genes deleted from the parent virus have an enhanced ability to proliferate in cells being cultured, and thus are easily produced. In addition, the recombinant viruses express an increased level of an exogenous antigen, and thus has enhanced immunogenic efficacy. Such recombinant virus vectors may be used in vaccines for preventing diseases, therapeutic vaccines, and molecular biological studies.
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公开(公告)号：US20160108371A1
公开(公告)日：2016-04-21
申请号：US14883752
申请日：2015-10-15
发明人： Ho Sun Son , Sang Gu Yeo , Sang Won Lee
IPC分类号： C12N7/00 , A61K39/285
CPC分类号： C12N15/86 , A61K39/07 , C12N2710/24121 , C12N2710/24134 , C12N2710/24143
摘要： Disclosed herein is a novel recombinant virus vector derived from the attenuated vaccinia virus strain KVAC103. The recombinant virus vector is obtained by inserting an exogenous gene into the KVAC103 and may be used as a safe vaccine delivery vehicle in mammals. Particularly, recombinant viruses obtained by rescuing some of the genes deleted from the parent virus have an enhanced ability to proliferate in cells being cultured, and thus are easily produced. In addition, the recombinant viruses express an increased level of an exogenous antigen, and thus has enhanced immunogenic efficacy. Such recombinant virus vectors may be used in vaccines for preventing diseases, therapeutic vaccines, and molecular biological studies.
摘要翻译： 本文公开了衍生自减毒痘苗病毒株KVAC103的新型重组病毒载体。 重组病毒载体通过将外源基因插入到KVAC103中而获得，并且可以用作哺乳动物中的安全疫苗递送载体。 特别地，通过拯救从母体病毒中删除的一些基因获得的重组病毒在培养的细胞中具有增强的增殖能力，因此容易产生。 此外，重组病毒表达增加的外源抗原水平，因此具有增强的免疫原性功效。 这样的重组病毒载体可用于预防疾病，治疗性疫苗和分子生物学研究的疫苗中。
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公开(公告)号：US20160106829A1
公开(公告)日：2016-04-21
申请号：US14883757
申请日：2015-10-15
发明人： Sang Gu Yeo , Ho Sun Son , June Woo Lee , Seung Bin Cha , Sun Hwa Lee , Kwi Sung Park
IPC分类号： A61K39/285 , C12N7/00
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5254 , C12N2710/24121 , C12N2710/24134 , C12N2710/24164
摘要： Disclosed herein is the attenuated vaccinia virus strain KVAC103 obtained by subculturing a vaccinia virus strain 103 times in VERO cells. The attenuated vaccinia virus strain KVAC103 has significantly low toxicity, shows reduced skin lesions, and, at the same time, induces effectively immune responses to poxvirus. Thus, it can be used as a poxvirus vaccine while causing less side effects.
摘要翻译： 本文公开了通过在VERO细胞中传代培养痘苗病毒株103次获得的减毒痘苗病毒株KVAC103。 减毒痘苗病毒株KVAC103具有显着低毒性，显示减少的皮肤损伤，并且同时诱导对痘病毒的免疫应答。 因此，它可以用作痘病毒疫苗，同时引起较少的副作用。
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