公开(公告)号：US20230287073A1

公开(公告)日：2023-09-14

申请号：US18147796

申请日：2022-12-29

申请人： Korea Institute of Ocean Science & Technology

发明人： Jung-Hyun LEE ,  Hyung-Soon YIM ,  Young Jun AN ,  Kyeong Won LEE ,  Ye Eun JEONG ,  Kiweon CHA ,  Won Kyu LEE

IPC分类号： C07K14/50

CPC分类号： C07K14/50

摘要： A thermally stable polypeptide having FGF7 activity is provided. The polypeptide is a thermally stable polypeptide having FGF7 activity, wherein, in SEQ ID NO: 1, a 120th alanine (A) is substituted with cysteine (C), one including at least one substitution selected from substitution of a 126th lysine (K) with aspartic acid (D) and a 178th lysine (K) with glutamic acid (E) or aspartic acid (D) forms a salt bridge with a 175th arginine (R), and a 133rd cysteine (C) and a 137th cysteine (C) are disulfide bonded.

公开(公告)号：US20230076299A1

公开(公告)日：2023-03-09

申请号：US17779210

申请日：2020-11-16

申请人： Kiweon CHA ,  Korea Institute of Ocean Science & Technology

发明人： Jung-Hyun LEE ,  Hyung-Soon YIM ,  Young Jun AN ,  Kyeon Won LEE ,  Ye Eun JEONG ,  Kiweon CHA ,  Won Kyu LEE ,  Jurang WOO

IPC分类号： C07K14/50 ,  C12N5/0735

摘要： Provided is a polypeptide having FGF2 activity and improved temperature stability and protease resistance. The polypeptide includes at least one substitution selected from a substitution of aspartic acid (D) with glutamic acid (E) at position 28, a substitution of cysteine (C) with isoleucine (I) or leucine (L) at position 78, or a substitution of cysteine (C) with isoleucine (I) or tryptophan (VV) at position 96 in SEQ ID NO: 1.