公开(公告)号：US20240352401A1

公开(公告)日：2024-10-24

申请号：US18521797

申请日：2023-11-28

Applicant: Korea Institute of Science and Technology

Inventor： Sun Mi LEE ,  Jiwon Kim ,  Hyeoncheol Son ,  Ja Kyong Ko ,  Gyeongtaek Gong ,  Jung Ho Ahn ,  Youngsoon Um

IPC: C12N1/16 ,  C12N9/02 ,  C12N15/81

CPC classification number: C12N1/165 ,  C12N9/0008 ,  C12N15/815 ,  C12R2001/645 ,  C12Y102/01003

Abstract: The present disclosure discloses a strain having resistance by neutralizing furfural, an inhibitor derived from lignocellulosic biomass, based on a technique using aldehyde dehydrogenase and a method of using the same. According to the present disclosure, furfural, an inhibitor derived from lignocellulosic biomass, is neutralized based on a technique using aldehyde dehydrogenase, so that a resistant strain overexpresses aldehyde dehydrogenase (EcAldH) in Yarrowia lipolytica, which has the ability to produce yeast oil, and has resistance to furfural, a biomass-derived inhibitor. Accordingly, even in the medium containing furfural, it can provide excellent strain growth and yeast oil production ability.