公开(公告)号：US20240352401A1

公开(公告)日：2024-10-24

申请号：US18521797

申请日：2023-11-28

Applicant: Korea Institute of Science and Technology

Inventor： Sun Mi LEE ,  Jiwon Kim ,  Hyeoncheol Son ,  Ja Kyong Ko ,  Gyeongtaek Gong ,  Jung Ho Ahn ,  Youngsoon Um

IPC: C12N1/16 ,  C12N9/02 ,  C12N15/81

CPC classification number: C12N1/165 ,  C12N9/0008 ,  C12N15/815 ,  C12R2001/645 ,  C12Y102/01003

Abstract: The present disclosure discloses a strain having resistance by neutralizing furfural, an inhibitor derived from lignocellulosic biomass, based on a technique using aldehyde dehydrogenase and a method of using the same. According to the present disclosure, furfural, an inhibitor derived from lignocellulosic biomass, is neutralized based on a technique using aldehyde dehydrogenase, so that a resistant strain overexpresses aldehyde dehydrogenase (EcAldH) in Yarrowia lipolytica, which has the ability to produce yeast oil, and has resistance to furfural, a biomass-derived inhibitor. Accordingly, even in the medium containing furfural, it can provide excellent strain growth and yeast oil production ability.

公开(公告)号：US11285492B2

公开(公告)日：2022-03-29

申请号：US16393967

申请日：2019-04-25

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sun Mi Lee ,  Yong-Sang Ryu ,  Eui-Sang Yu ,  Jiwon Kim ,  Ja Kyong Ko ,  Gyeongtaek Gong ,  Chulki Kim ,  Jae Hun Kim

IPC: B03C5/00 ,  C12P7/64 ,  C12P7/649

Abstract: Disclosed herein are a screening method of high-efficiency biofuel-producing strains by a dielectrophoretic method using vertical nano-gap electrodes and a producing method of biofuel from the screened strains.

公开(公告)号：US20200149071A1

公开(公告)日：2020-05-14

申请号：US16551335

申请日：2019-08-26

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sun Mi Lee ,  Phuong Nguyen Hoang Tran ,  Youngsoon Um ,  Gyeongtaek Gong ,  Ja Kyong Ko ,  Yeonjung Lee

IPC: C12N15/90 ,  C12N9/92 ,  C12N9/12 ,  C12N9/10 ,  C12P7/06 ,  C12N15/81 ,  C12N1/16 ,  C12N15/11 ,  C12N9/22 ,  C12N9/04 ,  C12N9/02

Abstract: The present specification relates to a transformed yeast strain capable of simultaneously utilizing xylose and glucose as carbon sources, a preparation method thereof and a biofuel production method using the same. The transformed yeast strain transforms a wild-type yeast strain incapable of using xylose as a carbon source and simultaneously convert glucose and xylose, thereby enabling high yield production of a biofuel. The economics and sustainability of the biofuel and biomaterial production processes can be highly enhanced by providing a strain which can easily be converted to a strain capable of producing a biofuel/material in a high yield through an additional modification.

公开(公告)号：US11932895B2

公开(公告)日：2024-03-19

申请号：US17849571

申请日：2022-06-24

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyun Ju Oh ,  Youngsoon Um ,  Sun Mi Lee ,  Gyeongtaek Gong ,  Ja Kyong Ko

IPC: C12P7/06 ,  C12P7/16 ,  C12R1/145

CPC classification number: C12P7/06 ,  C12P7/16 ,  C12R2001/145

Abstract: The present disclosure relates to a composition for preparing hexanol or butanol and a method for preparing hexanol or butanol using ethanol and synthesis gas, wherein the composition according to an aspect of the present disclosure is a medium composition containing ethanol as an active ingredient, and by culturing a strain producing hexanol or butanol after inoculating with a medium containing the composition and supplying synthesis gas, hexanol or butanol can be prepared economically using inexpensive synthesis gas, and hexanol or butanol can be prepared with high efficiency by focusing the flow of a carbon source consumed in a fermentation process to the production of hexanol or butanol.

公开(公告)号：US11319556B2

公开(公告)日：2022-05-03

申请号：US16551335

申请日：2019-08-26

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sun Mi Lee ,  Phuong Nguyen Hoang Tran ,  Youngsoon Um ,  Gyeongtaek Gong ,  Ja Kyong Ko ,  Yeonjung Lee

IPC: C12N15/90 ,  C12N1/16 ,  C12N15/81 ,  C12P7/06 ,  C12P7/16 ,  C12N9/04 ,  C12N9/02 ,  C12N9/10 ,  C12N9/12 ,  C12N9/92 ,  C12N15/11 ,  C12N9/22

Abstract: The present specification relates to a transformed yeast strain capable of simultaneously utilizing xylose and glucose as carbon sources, a preparation method thereof and a biofuel production method using the same. The transformed yeast strain transforms a wild-type yeast strain incapable of using xylose as a carbon source and simultaneously convert glucose and xylose, thereby enabling high yield production of a biofuel. The economics and sustainability of the biofuel and biomaterial production processes can be highly enhanced by providing a strain which can easily be converted to a strain capable of producing a biofuel/material in a high yield through an additional modification.