公开(公告)号：US08883796B2

公开(公告)日：2014-11-11

申请号：US13762567

申请日：2013-02-08

Applicant: Korea Institute of Science and Technology

Inventor： Hyunah Choo ,  Young-Jae Kim ,  Jeeyeon Kim ,  Mi Young Yeom

IPC: A61K31/4965 ,  C07D241/04

CPC classification number: C07D241/04 ,  C07D295/033 ,  C07D295/073 ,  C07D295/096

Abstract: Provided are biphenyl derivatives exhibiting activity towards central nervous system diseases by acting on the 5-HT7 receptor, pharmaceutically acceptable salts thereof, a method for preparing the compounds and pharmaceutical compositions including the compounds as an active ingredient.

Abstract translation: 提供了通过作用于5-HT 7受体，其药学上可接受的盐，制备该化合物的方法和包含该化合物作为活性成分的药物组合物，对中枢神经系统疾病具有活性的联苯衍生物。

公开(公告)号：US09663464B2

公开(公告)日：2017-05-30

申请号：US14629821

申请日：2015-02-24

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyunah Choo ,  Gyo Chang Keum ,  Youngjae Kim ,  Mi Young Yeom

IPC: C07D403/06 ,  A61K31/496 ,  C07D209/86 ,  C07D401/06 ,  C07D413/06

CPC classification number: C07D209/86 ,  C07D401/06 ,  C07D403/06 ,  C07D413/06

Abstract: The present invention provides a carbazole derivative represented by Formula 1: wherein X is CH2 or C(O), Y is selected from NR1R2, piperidinyl groups in which two of the carbon atoms are substituted with R3 and R4, piperazinyl groups in which the nitrogen atom is substituted with R5, and morpholinyl groups, n is an integer from 2 to 5, R1 and R2, which may be identical or different, are each independently selected from C1-C6 alkyl, phenyl, and benzyl, with the proviso that R1 and R2 may be bonded together to form a ring, R3 and R4, which may be identical or different, are each independently selected from hydrogen, C1-C6 alkyl, phenyl, and benzyl, and R5 is selected from C1-C6 alkyl, C1-C4 alkylcarbonyl, phenyl substituted with C1-C4 alkyloxy, hydroxyphenyl, benzyl, and benzoisoxazol-3-yl; or a pharmaceutically acceptable salt thereof.