公开(公告)号：US09980954B2

公开(公告)日：2018-05-29

申请号：US15403404

申请日：2017-01-11

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyunah Choo ,  Sun-Joon Min ,  Yun Kyung Kim ,  Hoon Ryu ,  Hyemyung Seo ,  Juhyeon Kim ,  Jihoon Jang ,  Sungsu Lim ,  Younghee Kim ,  Yu Jin Hwang ,  Yong Seo Cho

IPC: A61K31/47 ,  A61K31/4709 ,  A61K31/5377

CPC classification number: A61K31/47 ,  A61K31/4709 ,  A61K31/5377

Abstract: The present disclosure relates to a quinoline derivative which inhibits the activity of histone methyltransferases (ESET/SETDB1) specific for the histone molecule H3K9 or a pharmaceutically acceptable salt thereof and a use thereof.

公开(公告)号：US10435408B2

公开(公告)日：2019-10-08

申请号：US15738225

申请日：2017-11-06

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyunah Choo ,  Youngjae Kim ,  Jihye Seong ,  Ghil Soo Nam ,  Yong Seo Cho

IPC: C07D487/04 ,  C07D498/04 ,  A61K31/55 ,  A61K31/4162 ,  A61P25/22 ,  A61P25/24

Abstract: Azepine derivatives acting on 5-HT7 receptors and pharmaceutically acceptable salts thereof are disclosed. The azepine derivatives and the pharmaceutically acceptable salts thereof have high binding affinities for and high antagonistic activities on 5-HT7 receptors. Due to these advantages, the azepine derivatives and the pharmaceutically acceptable salts thereof can be applied to therapeutic or prophylactic agents for central nervous system diseases, such as depression, migraine, anxiety, pain, inflammatory pain, neuropathic pain, body temperature dysregulation, biorhythm dysregulation, sleep disturbance, and smooth muscle diseases where 5-HT7 receptors antagonistic activity is required.

公开(公告)号：US10138188B2

公开(公告)日：2018-11-27

申请号：US15653970

申请日：2017-07-19

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyun Joo Lee ,  Hyunah Choo ,  Seungmi Yeo ,  Tran Huyen Dang ,  Jieon Lee ,  Soon Hyeok Hong ,  Dabon Lee ,  Sang Deuk Lee

IPC: B01J27/02 ,  B01J31/22 ,  C07C29/12 ,  C07C29/48 ,  C07C31/04 ,  C07C303/24 ,  C07C305/06

Abstract: Disclosed is a novel catalyst for producing a methanol precursor. The use of the catalyst enables the production of a methanol precursor and methanol with high efficiency under low temperature and low pressure conditions. Also disclosed are a methanol precursor produced using the catalyst and methanol produced using the methanol precursor.

公开(公告)号：US09663464B2

公开(公告)日：2017-05-30

申请号：US14629821

申请日：2015-02-24

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyunah Choo ,  Gyo Chang Keum ,  Youngjae Kim ,  Mi Young Yeom

IPC: C07D403/06 ,  A61K31/496 ,  C07D209/86 ,  C07D401/06 ,  C07D413/06

CPC classification number: C07D209/86 ,  C07D401/06 ,  C07D403/06 ,  C07D413/06

Abstract: The present invention provides a carbazole derivative represented by Formula 1: wherein X is CH2 or C(O), Y is selected from NR1R2, piperidinyl groups in which two of the carbon atoms are substituted with R3 and R4, piperazinyl groups in which the nitrogen atom is substituted with R5, and morpholinyl groups, n is an integer from 2 to 5, R1 and R2, which may be identical or different, are each independently selected from C1-C6 alkyl, phenyl, and benzyl, with the proviso that R1 and R2 may be bonded together to form a ring, R3 and R4, which may be identical or different, are each independently selected from hydrogen, C1-C6 alkyl, phenyl, and benzyl, and R5 is selected from C1-C6 alkyl, C1-C4 alkylcarbonyl, phenyl substituted with C1-C4 alkyloxy, hydroxyphenyl, benzyl, and benzoisoxazol-3-yl; or a pharmaceutically acceptable salt thereof.

公开(公告)号：US09469653B2

公开(公告)日：2016-10-18

申请号：US14164616

申请日：2014-01-27

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Changjoon Justin Lee ,  Seonmi Jo ,  Boeun Yoon ,  Hyunah Choo ,  Ji Yoon Kim ,  Daesoo Kim

IPC: C07D513/04 ,  G01N33/68 ,  C07D498/04 ,  G01N33/50 ,  G01N33/94

CPC classification number: C07D498/04 ,  C07D513/04 ,  C12N2503/02 ,  G01N33/5058 ,  G01N33/6896 ,  G01N33/9426 ,  G01N2800/2814 ,  G01N2800/302

Abstract: A pharmaceutical composition for preventing or treating a degenerative brain disease, and a method of screening a material for preventing or treating a degenerative brain disease. The method may effectively screen a prophylactic or therapeutic candidate material for preventing or treating a degenerative brain disease. A variety of degenerative brain diseases may be effectively prevented or treated using the pharmaceutical composition including a screened material for preventing or treating a degenerative brain disease.

Abstract translation: 用于预防或治疗退行性脑病的药物组合物，以及筛选用于预防或治疗退行性脑病的材料的方法。 该方法可以有效地筛选用于预防或治疗退行性脑病的预防性或治疗性候选物质。 可以使用包括用于预防或治疗退行性脑病的筛选材料的药物组合物来有效地预防或治疗各种退行性脑疾病。

公开(公告)号：US09260448B2

公开(公告)日：2016-02-16

申请号：US14038324

申请日：2013-09-26

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyunah Choo ,  Sun Joon Min ,  Seon Hee Seo ,  Jee Yeon Kim ,  Yoo Ran Ki ,  Min Joo Kim ,  Sora Kim ,  Youngjae Kim

IPC: A01N43/90 ,  A61K31/519 ,  C07D491/00 ,  C07D495/00 ,  C07D495/04

CPC classification number: C07D495/04 ,  A61K31/519

Abstract: Disclosed are thienopyrimidinone derivatives as antagonists that act on metabotropic glutamate receptor subtype 1. The thienopyrimidinone derivatives show pharmacological activity against metabotropic glutamate receptor-related diseases, including pain, such as neuropathic pain and migraine, psychiatric diseases, such as anxiety disorder and schizophrenia, urinary incontinence, and neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease. Also disclosed are methods for preparing the thienopyrimidinone derivatives, and pharmaceutical compositions containing the thienopyrimidinone derivatives as active ingredients.

Abstract translation: 公开了作为代谢型谷氨酸受体亚型1的拮抗剂的噻吩并嘧啶酮衍生物。噻吩并嘧啶酮衍生物显示针对代谢型谷氨酸受体相关疾病的药理学活性，包括疼痛，如神经性疼痛和偏头痛，精神疾病如焦虑障碍和精神分裂症，尿 失禁和神经变性疾病，如帕金森病和阿尔茨海默病。 还公开了制备噻吩并嘧啶酮衍生物的方法和含有噻吩并嘧啶酮衍生物作为活性成分的药物组合物。

公开(公告)号：US08883796B2

公开(公告)日：2014-11-11

申请号：US13762567

申请日：2013-02-08

Applicant: Korea Institute of Science and Technology

Inventor： Hyunah Choo ,  Young-Jae Kim ,  Jeeyeon Kim ,  Mi Young Yeom

IPC: A61K31/4965 ,  C07D241/04

CPC classification number: C07D241/04 ,  C07D295/033 ,  C07D295/073 ,  C07D295/096

Abstract: Provided are biphenyl derivatives exhibiting activity towards central nervous system diseases by acting on the 5-HT7 receptor, pharmaceutically acceptable salts thereof, a method for preparing the compounds and pharmaceutical compositions including the compounds as an active ingredient.

Abstract translation: 提供了通过作用于5-HT 7受体，其药学上可接受的盐，制备该化合物的方法和包含该化合物作为活性成分的药物组合物，对中枢神经系统疾病具有活性的联苯衍生物。