公开(公告)号：US20170253860A1

公开(公告)日：2017-09-07

申请号：US15438215

申请日：2017-02-21

Applicant: Korea Institute of Science and Technology

Inventor： Nakwon CHOI ,  Sohyun KIM ,  Sohyeon JEONG ,  Eui Sung YOON ,  Changjoon Justin LEE ,  Il-Joo CHO

IPC: C12N5/09 ,  B29C43/18 ,  C12M3/00 ,  C08J7/04 ,  C12N5/00 ,  C12M1/12

CPC classification number: C12N5/0693 ,  B29C43/02 ,  B29C43/18 ,  B29C43/36 ,  B29C2043/185 ,  B29K2995/0046 ,  C08J7/047 ,  C08J2383/04 ,  C08J2465/00 ,  C12M21/08 ,  C12M25/14 ,  C12N5/0068 ,  C12N2513/00 ,  C12N2533/30 ,  C12N2533/54 ,  C12N2535/00

Abstract: The present disclosure relates to an apparatus and a method for manufacturing a channel-coupled scaffold. The present disclosure provides a method for manufacturing a channel-coupled scaffold, which includes: (1) a step of compressing a first elastic substrate which includes a groove on the surface of the substrate to close the groove; (2) a step of loading a scaffold composition onto the closed groove; and (3) a step of restoring the elastic substrate. The present disclosure also provides an apparatus for manufacturing a channel-coupled scaffold, which includes: a first elastic substrate which includes a groove on the surface of the substrate and onto which a scaffold composition is loaded: and a compression module which compresses the width of the groove of the elastic substrate to close it. The apparatus or method may accumulate a microchannel controlling local mass transfer, and align a collagen fiber in the scaffold at the same time.